scholarly journals Introducing Broadened Antibacterial Activity to Rhodanine Derivatives Targeting Enoyl-Acyl Carrier Protein Reductase

2019 ◽  
Vol 67 (2) ◽  
pp. 125-129
Author(s):  
Zhi-Gang Sun ◽  
Yun-Jie Xu ◽  
Jian-Fei Xu ◽  
Qi-Xing Liu ◽  
Yu-Shun Yang ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Acyl Carrier Protein ◽  
Carrier Protein

scholarly journals Antibacterial Activity of N-Pentylpantothenamide Is Due to Inhibition of Coenzyme A Synthesis

2010 ◽  
Vol 54 (3) ◽  
pp. 1374-1377 ◽  
Author(s):  
Jacob Thomas ◽  
John E. Cronan
Keyword(s):  
Antibacterial Activity ◽  
Growth Inhibition ◽  
Coenzyme A ◽  
Acyl Carrier Protein ◽  
Carrier Protein ◽  
Prosthetic Group ◽  
Protein Moiety

ABSTRACT Growth inhibition by the pantothenate analog N-pentylpantothenamide (N5-Pan) has been attributed to the accumulation of acyl carrier protein carrying a prosthetic group modified by incorporation of N5-Pan. This was attributed to an inability of the AcpH acyl carrier protein phosphodiesterase to cleave the N5-Pan-modified prosthetic group from the protein moiety. We report that AcpH readily removes the N5-Pan-modified prosthetic group both in vivo and in vitro and show that N5-Pan blocks coenzyme A synthesis.

scholarly journals A Review on Platensimycin: A Selective FabF Inhibitor

2016 ◽  
Vol 2016 ◽  
pp. 1-16 ◽  
Author(s):  
Manik Das ◽  
Partha Sakha Ghosh ◽  
Kuntal Manna
Keyword(s):  
Antibacterial Activity ◽  
Bacterial Infection ◽  
Secondary Metabolite ◽  
Acyl Carrier Protein ◽  
Carrier Protein ◽  
Structural Pattern ◽  
Gram Positive Bacteria ◽  
Streptomyces Platensis ◽  
Naturally Occurring ◽  
Retrosynthetic Analysis

Emerging resistance to existing antibiotics is an inevitable matter of concern in the treatment of bacterial infection. Naturally occurring unique class of natural antibiotic, platensimycin, a secondary metabolite from Streptomyces platensis, is an excellent breakthrough in recent antibiotic research with unique structural pattern and significant antibacterial activity. β-Ketoacyl-(acyl-carrier-protein (ACP)) synthase (FabF) whose Gram-positive bacteria need to biosynthesize cell membranes is the target of inhibition of platensimycin. So, isolation, retrosynthetic analysis, synthesis of platensimycin, and analogues of platensimycin synthesized till today are the objectives of this review which may be helpful to further investigate and to reveal untouched area on this molecule and to obtain a potential antibacterial lead with enhanced significant antibacterial activity.

Sign in / Sign up

Export Citation Format

Share Document