scholarly journals Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (ACP) Reductase Inhibitor

2014 ◽  
Vol 289 (23) ◽  
pp. 15987-16005 ◽  
Author(s):  
Johannes Schiebel ◽  
Andrew Chang ◽  
Sonam Shah ◽  
Yang Lu ◽  
Li Liu ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Broad Spectrum ◽  
Rational Design ◽  
Reductase Inhibitor ◽  
Acyl Carrier Protein ◽  
Carrier Protein

scholarly journals Introducing Broadened Antibacterial Activity to Rhodanine Derivatives Targeting Enoyl-Acyl Carrier Protein Reductase

2019 ◽  
Vol 67 (2) ◽  
pp. 125-129
Author(s):  
Zhi-Gang Sun ◽  
Yun-Jie Xu ◽  
Jian-Fei Xu ◽  
Qi-Xing Liu ◽  
Yu-Shun Yang ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Acyl Carrier Protein ◽  
Carrier Protein

scholarly journals Antibacterial Activity of N-Pentylpantothenamide Is Due to Inhibition of Coenzyme A Synthesis

2010 ◽  
Vol 54 (3) ◽  
pp. 1374-1377 ◽  
Author(s):  
Jacob Thomas ◽  
John E. Cronan
Keyword(s):  
Antibacterial Activity ◽  
Growth Inhibition ◽  
Coenzyme A ◽  
Acyl Carrier Protein ◽  
Carrier Protein ◽  
Prosthetic Group ◽  
Protein Moiety

ABSTRACT Growth inhibition by the pantothenate analog N-pentylpantothenamide (N5-Pan) has been attributed to the accumulation of acyl carrier protein carrying a prosthetic group modified by incorporation of N5-Pan. This was attributed to an inability of the AcpH acyl carrier protein phosphodiesterase to cleave the N5-Pan-modified prosthetic group from the protein moiety. We report that AcpH readily removes the N5-Pan-modified prosthetic group both in vivo and in vitro and show that N5-Pan blocks coenzyme A synthesis.

FabI (enoyl acyl carrier protein reductase) - A potential broad spectrum therapeutic target and its inhibitors

2020 ◽  
Vol 208 ◽  
pp. 112757 ◽  
Author(s):  
Preeti Rana ◽  
Shaik Mahammad Ghouse ◽  
Ravikumar Akunuri ◽  
Y.V. Madhavi ◽  
Sidharth Chopra ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Therapeutic Target ◽  
Acyl Carrier Protein ◽  
Carrier Protein

scholarly journals Rational Design of Berberine-Based FtsZ Inhibitors with Broad-Spectrum Antibacterial Activity

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e97514 ◽  
Author(s):  
Ning Sun ◽  
Fung-Yi Chan ◽  
Yu-Jing Lu ◽  
Marco A. C. Neves ◽  
Hok-Kiu Lui ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Broad Spectrum ◽  
Rational Design ◽  
Ftsz Inhibitors
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