E-33 Free Communication/Poster - Vascular Responses to Acute Exercise

2013 ◽  
Vol 45 (5S) ◽  
pp. 513-517
1997 ◽  
Vol 29 (Supplement) ◽  
pp. 138
Author(s):  
R. H. Cox ◽  
M. P. Chandler ◽  
S. E. DiCarlo

2019 ◽  
Vol 51 (Supplement) ◽  
pp. 806-807
Author(s):  
Andrea Tryfonos ◽  
Rafaella Rodighiero ◽  
Matt Cocks ◽  
Joseph Mills ◽  
Daniel J. Green ◽  
...  

1983 ◽  
Vol 49 (01) ◽  
pp. 053-057 ◽  
Author(s):  
Robert G Kopitsky ◽  
Mary Ellen P Switzer ◽  
R Sanders Williams ◽  
Patrick A McKee

SummaryWe studied the effect of acute exercise on the ability of thrombin to activate plasma factor VIII (FVIII) activity in 20 healthy males. The subject showed an average exercise-related increase in FVIII activity of 54.5±8.2% over pre-exercise FVIII activity (p<0.001). When exposed to the same concentration of thrombin, post-exercise FVIII activity showed greater enhancement than pre-exercise FVIII activity: 157.1±12.8% increase in activity versus 117.3±9.9%, respectively (p<0.01). The degree of the potentiated thrombin effect in post-exercise samples relative to pre-exercise samples was linearly correlated with the degree of the exercise-related increase in FVIII activity. Taken together with our previous observations that the extent of thrombin enhancement of FVIII activity varies inversely with the mole ratio of FVIII/von Willebrand factor subunits to thrombin, these findings imply that release of FVIII does not occur during exercise, and that the exercise-related increase in FVIII activity results primarily, if not completely, from activation of already circulating but inactive FVIII.


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