scholarly journals Biochemical studies on the mechanism of action of cardiac glycosides

1959 ◽  
Vol 55 (5) ◽  
pp. 933-938
Author(s):  
Kazuo KAWAI
Keyword(s):  
Mechanism Of Action ◽  
Cardiac Glycosides ◽  
Biochemical Studies

Studies related to the mechanism of action of cardiac glycosides. On the reactions of thiols with unsaturated lactones and on the structure of the compound previously reported as ouabagenin. The preparation and properties of authentic ouabagenin

1970 ◽  
Vol 48 (24) ◽  
pp. 3819-3826 ◽  
Author(s):  
J. Bryan Jones ◽  
Hugh W. Middleton
Keyword(s):  
Mechanism Of Action ◽  
Michael Addition ◽  
Cardiac Glycosides ◽  
Enoic Acid ◽  
Addition Reactions ◽  
Unsaturated Lactones

In connection with mechanism of action studies on cardiac glycosides, the reactions of α-pyrone, γ-crotonolactone, digitoxigenin, and ouabagenin have been studied. No Michael addition reactions were observed with the cardenolide aglycones. The compound previously reported in the literature as ouabagenin has been shown to be 1β,3β,5β,11α,14β,19,21-heptahydroxycard-20,22-enoic acid and the preparation and properties of authentic ouabagenin are described.

Mechanism of action of cardiac glycosides

1984 ◽  
Vol 5 (suppl F) ◽  
pp. 303-308 ◽  
Author(s):  
T. Godfraind
Keyword(s):  
Mechanism Of Action ◽  
Cardiac Glycosides
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