Building Electronic Ecosystem of Religious Islamic Education

The article describes the most important stages of creating an ecosystem of electronic religious education. It also presents one of the possible models for the formation of an electronic informational and educational environment. At the present stage with all the technical prerequisites having been created there is already a widespread basis for the formation of electronic educational ecosystem at almost all levels of religious education. Moreover, there is a lag in the use of new technologies in teaching. Forming electronic educational environment will create additional tools and conditions for analyzing the indicators referred to the educational process, it also will provide a holistic view on the state of the educational system, will reveal qualitative and quantitative changes in it.

Breaking constraint of mammalian axial formulae

The vertebral column of individual mammalian species often exhibits remarkable robustness in the number and identity of vertebral elements that form (known as axial formulae). The genetic mechanism(s) underlying this constraint however remain ill-defined. Here, we reveal the interplay of three regulatory pathways (Gdf11, miR-196 and Retinoic acid) is essential in constraining total vertebral number and regional axial identity in the mouse, from cervical through to tail vertebrae. All three pathways have differing control over Hox cluster expression, with heterochronic and quantitative changes found to parallel changes in axial identity. However, our work reveals an additional role for Hox genes in supporting axial elongation within the tail region, providing important support for an emerging view that mammalian Hox function is not limited to imparting positional identity as the mammalian body plan is laid down. More broadly, this work provides a molecular framework to interrogate mechanisms of evolutionary change and congenital anomalies of the vertebral column.

Comprehensive quantitative analysis of alternative splicing variants reveals the HNF1B mRNA splicing pattern in various tumour and non-tumour tissues

Hepatocyte nuclear factor-1-beta (HNF1B) is a transcription factor and putative biomarker of solid tumours. Recently, we have revealed a variety of HNF1B mRNA alternative splicing variants (ASVs) with unknown, but potentially regulatory, functions. The aim of our work was to quantify the most common variants and compare their expression in tumour and non-tumour tissues of the large intestine, prostate, and kidney. The HNF1B mRNA variants 3p, Δ7, Δ7–8, and Δ8 were expressed across all the analysed tissues in 28.2–33.5%, 1.5–2%, 0.8–1.7%, and 2.3–6.9% of overall HNF1B mRNA expression, respectively, and occurred individually or in combination. The quantitative changes of ASVs between tumour and non-tumour tissue were observed for the large intestine (3p, Δ7–8), prostate (3p), and kidney samples (Δ7). Decreased expression of the overall HNF1B mRNA in the large intestine and prostate cancer samples compared with the corresponding non-tumour samples was observed (p = 0.019 and p = 0.047, respectively). The decreased mRNA expression correlated with decreased protein expression in large intestine carcinomas (p < 0.001). The qualitative and quantitative pattern of the ASVs studied by droplet digital PCR was confirmed by next-generation sequencing, which suggests the significance of the NGS approach for further massive evaluation of the splicing patterns in a variety of genes.

Probiotics with estriol in the treatment of acute and recurrent vaginal and vulvar infections in women

The microbiome undergoes qualitative and quantitative changes at different times in a woman’s life, and their nature is due to many factors such as age, sexual activity, comorbidities, etc. As a result, vaginal dryness and inflammation can occur in the vagina. This problem is most important during the menopausal period, when estrogen secretion decreases – this induces a cascade of unfavorable biological effects. We can prevent them by adding probiotics to the standard menopausal hormonotherapy. Adding probiotics restore and maintain the proper microbiological condition of the vagina. The use of probiotics reduces the risk of developing ailments that require antibiotic therapy, which is also detrimental to the vaginal microbiome.

Precise measurement of nanoscopic septin ring structures in deep learning-assisted quantitative superresolution microscopy

The combination of image analysis and fluorescence superresolution microscopy methods allows for unprecedented insight into the organization of macromolecular assemblies in cells. Advances in deep learning-based object recognition enables the automated processing of large amounts of data, resulting in high accuracy through averaging. However, while the analysis of highly symmetric structures of constant size allows for a resolution approaching the dimensions of structural biology, deep learning methods are prone to different forms of bias. A biased recognition of structures may prohibit the development of readouts for processes that involve significant changes in size or shape of amorphous macromolecular complexes. What is required to overcome this problem is a detailed investigation of potential sources of bias and the rigorous testing of trained models using real or simulated data covering a wide dynamic range of possible results. Here we combine single molecule localization-based superresolution microscopy of septin ring structures with the training of several different deep learning models for a quantitative investigation of bias resulting from different training approaches and finally quantitative changes in septin ring structures. We find that trade-off exists between measurement accuracy and the dynamic range of recognized phenotypes. Using our trained models, we furthermore find that septin ring size can be explained by the number of subunits they are assembled from alone. Our work provides a new experimental system for the investigation of septin polymerization.

On Continuity and Readiness for Education: Methodology Principles of Quality-Based System Management After Helen N. Solovova

This paper is devoted to the analysis of the most crucial problems related to innovative trends in modern education, i.e. increasing competitiveness. The aim of this paper is twofold: a) to consider the phenomenon of current methodology of professional education in terms of international principles ISO depicted in the research works of the outstanding methodologist and educator, Professor Helen N. Solovova; b) to reveal the versatility of the scientist’s activities in the frameworks of current academic scholarship. The main methodological concept considers the global strategic processes, and the value orientations of educational activity which become especially significant for those who have to work with a personality; the latter has to understand the realia of continuing transformations of the society, qualitative and quantitative changes in the educational environment of the country and the regions, and rather ambiguous social, informational, and educational aspects of the information spaces. As a result of this study, we state that current challenges are of prior importance for the personality development as individuality. As a priority this concerns a constantly changing status of education as a whole, and the image of the university and college trainers, school educators and tutors at In-Service institutions; as is the case, these phenomena reflected in both Russian and International Scientific Scholarship help to understand the progressive methodology principles which cover Knowledge Content, Technology, and Pedagogy/Language Didactics. In conclusion, a special role, for sure, belongs to the methodology of teaching foreign languages (H.Solovova’s concept of prior significance), which performs a humanizing and cultural mission; language pedagogy and didactics are in search of novel principles and approaches to the philosophy of training and learning foreign languages as a valuable intellectual component of Russian culture and education as a whole.

Levels of changes in the genus Pinus Linné in the composition of Mesozoic and Cenozoic flora and vegetation as an additional criterion for the division of sediments by the Mesozoic and Cenozoic of Ukraine

The article presents an analysis of a large array of results of palynological studies of Mesozoic and Cenozoic sediments of Ukraine and adjacent regions of Belarus and Russia. Numerous literature data on the palynological characteristics of Meso-Cenozoic sediments and the materials of the authors are summarized according to the results of spore-pollen analysis of Mesozoic and Cenozoic sediments within the main tectonic structures of Ukraine. It has been established that the genus Pinus (Pinaceae) is an integral part of the Meso-Cenozoic flora of Ukraine. Although, the participation in the flora and vegetation of the genus Pinus and its species diversity in different periods of geological time were different. Despite the long history and significant achievements of palynological research of Meso-Cenozoic sediments of Ukraine, no attention has been paid to the historical aspect of Pinus development in the Meso-Cenozoic flora. This work is presented as the first stem to fill this gap. The genus Pinus has a large stratigraphic range, but its species diversity and quantitative changes in the composition of Mesozoic and Cenozoic flora of different ages are markedly different. The analysis of these changes made it possible to trace the emergence and main levels at which the species composition was renewed and the role of Pinus in flora increased during the Mesozoic and Cenozoic. According to the results of the research, 5 levels of increasing the participation of the genus Pinus and changes in its species affiliation in the Mesozoic flora were established: Aalenian period of the Middle Jurassic (appearance of the first representatives of Pinus); Oxfordian time of the Late Jurassic; Valanginian – Early Barremian times of the Early Cretaceous; Albian time of the Early Cretaceous; Late Campanian time of the Late Cretaceous. 5 levels of increasing the role of Pinus and its species diversity for the flora and vegetation of the Cenozoic were also established: Oligocene time of the Paleogene, Konkian-early Sarmatian time of the Middle Miocene; early Pontian (Ivankov) time of the Late Miocene; early Kimmerian time (early Sevastopol) of the Early Pliocene and Martonosha time of the Early Neopleistocene. Certain levels have been traced for the similar age of Cenozoic flora of Belarus and Russia.

A Dyadic View on the Post-separation Network of Single Mothers

Many empirical studies have focused on the quantitative changes in the social networks of divorced and separated people. In this qualitative study, we use interviews with dyads to construct a two-sided view of the support network after separation. The aim of the study is to gain insight into the needs for support after a relational breakup. Including a network member in the analysis enables a more detailed view on the interaction at hand in the bond between these women and their supportive network members. The results show that personal coping resources are left untouched. Giving advice on ones daily activities is counter-productive. This is better understood by non family members compared to the women’s parents (especially the mother). With respect to the reciprocity in these relationships, network members do not expect a return in the period after the separation.

A Review on the Mechanism and Application of Keishibukuryogan

The concept of “blood stasis” – called yū xiě in Chinese, Oketsu in Japanese – is one of the unique pathophysiology of traditional medicine that originated in China and inherited in Korea and Japan. This concept is related to the multiple aspects of hemodynamic disorders brought on by quantitative and qualitative changes. It theorizes that the quantitative changes of “blood stasis” are related to peripheral circulatory insufficiency. When chronic qualitative changes of “blood stasis” produce stagnant blood that turns into a pathological product, it could cause inflammation and lead to organic changes. Trauma induced hematomas, that are considered to be a quantitative change of blood, are also a form of blood stasis. The basic medicine research on Keishibukuryogan (KBG)–a Japanese name in Traditional Japanese Medicine (Kampo) for one of the most common anti- “blood stasis” prescriptions, also known as gui-zhi-fu-ling-wan (GFW) in Chinese in Traditional Chinese Medicine (TCM)–indicated that the initiation of quantitative changes was closely related to loss of redox balances on endothelial function induced by oxidative stress. The following qualitative changes were related to coagulopathy, hyper viscosity; anti-platelet aggregation, lipid metabolism; a regulation of systemic leptin level and/or lipid metabolism, inflammatory factor; cyclooxygenase-1,2 (COX-1, 2), interleukin-6, 8 tumor necrosis factor-α, macrophage infiltration, hyperplasia, tissue fibrosis and sclerosis caused by transforming growth factor-β1 and fibronectin, the dysfunction of regulated cell deaths, such as, apoptosis, autophagy, ferroptosis and ovarian hormone imbalance. Clinically, KBG was often used for diseases related to Obstetrics and Gynecology, Endocrine Metabolism, Rheumatology and Dermatology. In this review, we give an overview of the mechanism and its current clinical application of KBG through a summary of the basic and clinical research and discuss future perspective.