INVESTIGATIONS OF THE INFLUENCE OF SUFAN ON MYOCARDIAL METABOLISM IN CASES OF EXPERIMENTAL HEART FAILURE
Keyword(s):
This article presents the results of an influence by the new non-glycoside structure, metabolic cardiotonic drug “sufan” on the energetic metabolism and oxidative homeostasis indicators—in myocardium, brain, and spleen of intact rats and rats with adriamycin-induced heart failure. It was established that sufan increased the coefficient of oxidative/reduced forms of nicotinamide coenzymes, reduced the adriamycin, causing deterioration of the energetic metabolism and the pro-oxidative-anti-oxidative homeostasis. The use of the non-glycoside structure cardiotonic drug, sufan, is recommended in order to prevent cardiotoxic effects of the anthracycline antibiotics.
2003 ◽
Vol 2
(1)
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pp. 32
Keyword(s):
2010 ◽
Vol 48
(5)
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pp. 999-1006
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1997 ◽
Vol 197
(4)
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pp. 177-187
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2006 ◽
Vol 5
(1)
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pp. 94-94