Laser Projection Positioning Improving at a Machine- Building Manufacturing Enterprise Method

The goal of this work is to research a possibility of laser projection system adaptation to a machine-building manufacturing enterprise. A model example of the use of a computer vision system in production is the task of reducing the labor intensity of installing welded elements on a product, reducing the production time, and reducing the cost of work. A formal statement of the problem is given - to use a laser projection system in the conditions of assembly and welding production for positioning welded elements on the main product with respect to dimensional accuracy. For experimental research, a section of a machine-building production enterprise with a pre-defective product and welded elements was used. The research took place in two stages. As a result of the research, the results were obtained, confirming the efficiency of the method.

Cross-Layer Adaptation with Safety-Assured Proactive Task Job Skipping

During the operation of many real-time safety-critical systems, there are often strong needs for adapting to a dynamic environment or evolving mission objectives, e.g., increasing sampling and control frequencies of some functions to improve their performance under certain situations. However, a system's ability to adapt is often limited by tight resource constraints and rigid periodic execution requirements. In this work, we present a cross-layer approach to improve system adaptability by allowing proactive skipping of task executions, so that the resources can be either saved directly or re-allocated to other tasks for their performance improvement. Our approach includes three novel elements: (1) formal methods for deriving the feasible skipping choices of control tasks with safety guarantees at the functional layer, (2) a schedulability analysis method for assessing system feasibility at the architectural layer under allowed task job skippings, and (3) a runtime adaptation algorithm that efficiently explores job skipping choices and task priorities for meeting system adaptation requirements while ensuring system safety and timing correctness. Experiments demonstrate the effectiveness of our approach in meeting system adaptation needs.

An anthropogenic model of cardiovascular system adaptation to the Earth’s gravity as the conceptual basis of pathological anthropology

Applying human biological evolution to solve topical problems of medicine and preventive cardiology was inspired by the realization of the need for clinical and experimental studies of biological (evolutionary) prerequisites in the occurrence of a pathology. Although it has been stated that there is a need to provide a full biological understanding of features, including those that increase an animal’s vulnerability to diseases, unfortunately, in this regard, erectile and associated adaptations to the Earth’s gravity in their physiological and pathological manifestations have not been considered. At the same time, it should be noted that humans, unlike other animal species, have the greatest vulnerability of the cardiovascular system (CVS). The latter is associated with fundamental differences in the functioning and regulation of the CVS by the influence of gravity on blood circulation in humans as upright creatures. Based on a review of comparative physiological, ontogenetic, and clinical studies from an evolutionary perspective, the idea of adaptation to the Earth’s gravity when walking upright in humans is justified as an anthropogenic basis for the physiology and pathology of the cardiovascular system and hemodynamic support systems (physio-anthropology and pathological anthropology).

Population genomic consequences of novel life history and mating system adaptation to a geothermal soil mosaic in yellow monkeyflowers (Mimulus guttatus)

Local selection can promote phenotypic divergence despite gene flow across habitat mosaics, but adaptation itself may generate substantial barriers to genetic exchange. In plants, life-history, phenology, and mating system divergence have been particularly proposed to promote genetic differentiation in sympatry. In this study, we investigate phenotypic and genetic variation in Mimulus guttatus (yellow monkeyflowers) across a geothermal soil mosaic in Yellowstone National Park (YNP). Plants from thermal annual and nonthermal perennial habitats were heritably differentiated for life history and mating system traits, consistent with local adaptation to the ephemeral thermal-soil growing season. However, genome-wide genetic variation primarily clustered plants by geographic region, with little variation sorting by habitat. The one exception was an extreme thermal population also isolated by a 200m geographical gap. Individual inbreeding coefficients (FIS) were higher (and predicted by trait variation) in annual plants and annual pairs showed greater isolation by distance at local (<1km) scales. Finally, YNP adaptation does not re-use a widespread inversion polymorphism diagnostic of annual vs. perennial M. guttatus range-wide, suggesting a novel genetic mechanism. Overall, this work suggests that life history and mating system adaptation strong enough to shape individual mating patterns does not necessarily generate incipient speciation without geographical barriers.

Staring at the Naked Goddess: Unraveling the Structure and Reactivity of Artemis Endonuclease Interacting with a DNA Double Strand

Artemis is an endonuclease responsible for breaking hairpin DNA strands during immune system adaptation and maturation as well as the processing of potentially toxic DNA lesions. Thus, Artemis may be an important target in the development of anticancer therapy, both for the sensitization of radiotherapy and for immunotherapy. Despite its importance, its structure has been resolved only recently, and important questions concerning the arrangement of its active center, the interaction with the DNA substrate, and the catalytic mechanism remain unanswered. In this contribution, by performing extensive molecular dynamic simulations, both classically and at the hybrid quantum mechanics/molecular mechanics level, we evidenced the stable interaction modes of Artemis with a model DNA strand. We also analyzed the catalytic cycle providing the free energy profile and key transition states for the DNA cleavage reaction.

Improvement of the professional orientation system, adaptation and promotion of nursing staff in medical organization

The aim of the study is to improve the system of vocational guidance, adaptation and promotion of nursing personnel in a medical organization. Results: an assessment was made of the organization of vocational guidance, factors affecting labor adaptation, the conditions necessary for promotion up the career ladder and the role of a senior nurse in all designated areas. Conclusion: The personnel management system implies, first of all, a well-functioning procedure for the entry of new employees into the organization, which allows to reduce material costs, time costs, staff turnover, psycho-emotional stress. The formation of a positive attitude of new employees to work, in the future, is influenced by a conscious choice of profession (professional orientation) and the possibility of career advancement.