Harmonized protocols forthe adoption of standardized analytical methods and for the presentation of their performance characteristics

1990 ◽  
Vol 62 (1) ◽  
pp. 149-162 ◽  
Author(s):  
W. D. Pocklington
Keyword(s):  
Analytical Methods ◽  
Performance Characteristics

Role of Collaborative and Cooperative Studies in Evaluation of Analytical Methods

1986 ◽  
Vol 69 (3) ◽  
pp. 398-400
Author(s):  
John K Taylor
Keyword(s):  
Quality Assurance ◽  
Analytical Methods ◽  
Regulatory Process ◽  
Measurement Process ◽  
Performance Characteristics ◽  
Collaborative Testing ◽  
Typical Performance

Abstract A method proposed as a standard or for use in a regulatory process must be reliable and its typical performance characteristics should be stated and verified. Collaborative testing is the most acceptable way to accomplish the latter but its function should not be misunderstood. Such testing can verify performance characteristics and experimentally demonstrate that the methodology can be used successfully by a representative group of laboratories. It does not necessarily support the validity of any data obtained using the method because this may depend on many other factors including the expertise of the laboratory and the quality assurance aspects of its measurement process.

Assessment of Analytical Method Performance Characteristics : Systematic Error

1977 ◽  
Vol 60 (4) ◽  
pp. 940-945
Author(s):  
Thomas J Dols ◽  
Bernard H Armbrecht
Keyword(s):  
Systematic Error ◽  
Analytical Method ◽  
Performance Characteristic ◽  
Analytical Methods ◽  
Performance Characteristics ◽  
Method Performance

Abstract A random review of the analytical literature shows the need to define more clearly the terms for techniques that are used to assess the merits of analytical methods for a particular purpose. One such performance characteristic is the systematic error or bias of a method. This term is defined and contrasted with other terms commonly used in method assessment. Components of the systematic error are described and techniques are given for their measurement.

Evaluation of Performance Characteristics of Multistep Analytical Methods from Collaborative Study of Linked Samples

2008 ◽  
Vol 80 (19) ◽  
pp. 7327-7335
Author(s):  
David L. Duewer ◽  
Michele M. Schantz ◽  
Reenie M. Parris ◽  
Franz Ulberth
Keyword(s):  
Analytical Methods ◽  
Collaborative Study ◽  
Performance Characteristics ◽  
Evaluation Of Performance

scholarly journals Essential Terminology and Considerations for Validation of Non-targeted Methods

2021 ◽  
Author(s):  
Kapil Nichani ◽  
Steffen Uhlig ◽  
Manfred Stoyke ◽  
Sabine Kemmlein ◽  
Franz Ulberth ◽  
...  
Keyword(s):  
Analytical Methods ◽  
Academic Research ◽  
Performance Characteristics ◽  
Commercial Development ◽  
Official Control ◽  
Food And Feed ◽  
Fit For Purpose ◽  
New Form

Through its suggestive name, non-targeted methods (NTMs) do not aim at a predefined "needle in the haystack". Instead, they exploit all the constituents of the haystack. This new form of analytical methods is increasingly finding applications in food and feed testing. However, the concepts, terms, and considerations related to this burgeoning field of analytical testing needs to be propagated for the benefit of ones associated in academic research, commercial development, and official control. This paper addresses the frequently asked questions around notations and terminologies surrounding NTMs. The widespread development and adoption of these methods also necessitates the need to develop approaches to NTM validation, i.e., evaluating the performance characteristics of a method to determine if it is fit-for-purpose. This work aims to provide a roadmap to approaching NTM validation. In doing so, the paper deliberates on the different considerations that influence the approach to validation and provides suggestions thereof.

Analytical Methods for Sulfonamides in Foods and Feeds. II. Performance Characteristics of Sulfonamide Methods

1981 ◽  
Vol 64 (4) ◽  
pp. 814-824 ◽  
Author(s):  
William Horwitz
Keyword(s):  
Coefficient Of Variation ◽  
Analytical Methods ◽  
Performance Characteristics ◽  
Regulatory Agencies ◽  
Reliable Measurement ◽  
Tissue Residue ◽  
Individual Laboratory ◽  
Collaborative Studies ◽  
The Individual

Abstract Important factors in interpretation of methods for sulfonamides in tissues are value of the blank, use or omission of recovery factors, and precision of the methods. For determining sulfonamide in tissues, no interlaboratory collaborative studies have been performed to provide reproducibility parameters. By assuming comparability with other tissue residue methods at equivalent concentrations, it may be anticipated that the coefficient of variation withinlaboratories of the Bratton-Marshall method is about 15% at concentrations of a fraction of a part per million. It is estimated that the limit of reliable measurement of the Bratton-Marshall method is about 0.2 ppm, varying with the individual laboratory. This value is higher than the tolerance it is intended to enforce. Obviously, the method in this case has been stretched beyond its original claimed capabilities. This method also has high blanks and low recoveries. Assignment of sufficient resources to the solution of the problem by regulatory agencies has resulted in methods capable of handling the sulfonamide residue problem at 0.1 ppm.

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