"We Fortunate Souls": Timely Death and Philosophical Therapy in Seneca's Consolation to Marcia

2021 ◽  
Vol 142 (3) ◽  
pp. 425-460
Author(s):  
James L. Zainaldin
Keyword(s):  
2009 ◽  
pp. 132-135
Author(s):  
Colin Read
Keyword(s):  

2014 ◽  
Vol 21 (5) ◽  
pp. e3
Author(s):  
Isa Fonnegra
Keyword(s):  

2012 ◽  
Vol 41 (3) ◽  
pp. 421-434
Author(s):  
Roger Scruton
Keyword(s):  

2012 ◽  
Vol 34 (2) ◽  
pp. 14-19
Author(s):  
Jon D. Lane ◽  
Virginie M.S. Betin ◽  
Lilith Mannack ◽  
Tom D.B. MacVicar

Since the publication of seminal work in the early 1970s by John Kerr and Andrew Wyllie1, we have been aware that mammalian cells have the genetically encoded capability to give up the ghost and trigger a highly conserved cell-suicide pathway called apoptosis. Not content with this important knowledge, many researchers have spent the intervening years attempting to identify and characterize other ‘programmed cell death’ (PCD) mechanisms that might also have important roles in development and disease. One of these was ‘autophagy’, a process by which cells became vacuolated and progressively devoid of cytoplasm. Over the years, ‘autophagic cell death’ has been linked with the timely death of cells in development, as well as the catastrophic loss of cells in several important human diseases. But is autophagy truly a cell death mechanism in its own right? Perhaps it is just an innocent bystander, unfairly accused on the basis of flimsy circumstantial evidence? The jury may finally be poised to return a decisive verdict….


2019 ◽  
Author(s):  
Nadia S. Kurd ◽  
Lydia K. Lutes ◽  
Jaewon Yoon ◽  
Ivan L. Dzhagalov ◽  
Ashley Hoover ◽  
...  

AbstractAutoreactive thymocytes are eliminated during negative selection in the thymus, a process important for establishing self-tolerance. Thymic phagocytes serve to remove dead thymocytes, but whether they play additional roles during negative selection remains unclear. Here, we demonstrate that phagocytosis promotes negative selection, and that negative selection is more efficient when the phagocyte also presents the negative selecting peptide. Our findings support a two-step model for negative selection in which thymocytes initiate the death process following strong TCR signaling, but ultimately depend upon phagocytosis for their timely death. Thus, the phagocytic capability of cells that present self-peptides is a key determinant of thymocyte fate.


Author(s):  
Richard Taruskin

The Rite of Spring is a composition that no one could have predicted at the time Stravinsky met Diaghilev. It took the timely death of Rimsky-Korsakov to make Stravinsky available to the Diaghilev enterprise, and without Diaghilev’s intervention it would never have occurred to a former pupil of Rimsky-Korsakov to write a ballet. The essay concludes with a consideration of the changing ways in which folklore was incorporated into Stravinsky’s early ballets, and cites one specific instance in which music intended for The Rite actually went into Petrushka.


2007 ◽  
Vol 30 (3) ◽  
pp. 213-229 ◽  
Author(s):  
Delphine Mordey

On 13 May 1871 Auber died. His passing was blamed on the horrors of the Franco-Prussian War, Siege and Commune, and provided a powerful symbol of the end of an era. Indeed, the idea that the debacle of 1870-71 caused a rupture in French music, one embodied in Auber's death, continues to influence music histories; political events are thought to mark a clear turning point away from the operettas of the Second Empire to the more serious works associated with the Third Republic. This notion of a turning point has much to recommend it, but the accepted history may ultimately be better viewed as an example of an apocalyptic narrative; after the event, the infamous frivolity of Napoleon III's era was seen to have led, inexorably, to defeat in the War, and to steep cultural change. I argue that this narrative was retrospectively constructed by contemporary music critics dissatisfied with existing French musical culture. The siege, the Commune, and the "timely" death of Auber were used as a means of bolstering demands for change: if the nation were to recover, she would have to change her ways, musical and otherwise. This constructed narrative obscures the picture suggested by primary sources; that not only had changes begun before the war, but that light-hearted forms continued to flourish afterward. It is clearly a narrative in need of historical revision.


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