scholarly journals Reversal of Secondary Hyperparathyroidism by Phosphate Restriction Restores Parathyroid Calcium-Sensing Receptor Expression and Function

2002 ◽  
Vol 17 (12) ◽  
pp. 2206-2213 ◽  
Author(s):  
Cynthia S. Ritter ◽  
Daniel R. Martin ◽  
Yan Lu ◽  
Eduardo Slatopolsky ◽  
Alex J. Brown
Keyword(s):  
Secondary Hyperparathyroidism ◽  
Receptor Expression ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
And Function

scholarly journals Relationship between parathyroid calcium-sensing receptor expression and potency of the calcimimetic, cinacalcet, in suppressing parathyroid hormone secretion in an in vivo murine model of primary hyperparathyroidism

2005 ◽  
Vol 153 (4) ◽  
pp. 587-594 ◽  
Author(s):  
Takehisa Kawata ◽  
Yasuo Imanishi ◽  
Keisuke Kobayashi ◽  
Takao Kenko ◽  
Michihito Wada ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Primary Hyperparathyroidism ◽  
Secondary Hyperparathyroidism ◽  
Murine Model ◽  
Hormone Secretion ◽  
Suppressive Effect ◽  
Receptor Expression ◽  
Parathyroid Glands ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing

Cinacalcet HCl, an allosteric modulator of the calcium-sensing receptor (CaR), has recently been approved for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis, due to its suppressive effect on parathyroid hormone (PTH) secretion. Although cinacalcet’s effects in patients with primary and secondary hyperparathyroidism have been reported, the crucial relationship between the effect of calcimimetics and CaR expression on the parathyroid glands requires better understanding. To investigate its suppressive effect on PTH secretion in primary hyperparathyroidism, in which hypercalcemia may already have stimulated considerable CaR activity, we investigated the effect of cinacalcet HCl on PTH-cyclin D1 transgenic mice (PC2 mice), a model of primary hyperparathyroidism with hypo-expression of CaR on their parathyroid glands. A single administration of 30 mg/kg body weight (BW) of cinacalcet HCl significantly suppressed serum calcium (Ca) levels 2 h after administration in 65- to 85-week-old PC2 mice with chronic biochemical hyperparathyroidism. The percentage reduction in serum PTH was significantly correlated with CaR hypo-expression in the parathyroid glands. In older PC2 mice (93–99 weeks old) with advanced hyperparathyroidism, serum Ca and PTH levels were not suppressed by 30 mg cinacalcet HCl/kg. However, serum Ca and PTH levels were significantly suppressed by 100 mg/kg of cinacalcet HCl, suggesting that higher doses of this compound could overcome severe hyperparathyroidism. To conclude, cinacalcet HCl demonstrated potency in a murine model of primary hyperparathyroidism in spite of any presumed endogenous CaR activation by hypercalcemia and hypo-expression of CaR in the parathyroid glands.

scholarly journals Regulation of E-cadherin and β-catenin by Ca2+ in colon carcinoma is dependent on calcium-sensing receptor expression and function

2007 ◽  
Vol 121 (7) ◽  
pp. 1455-1462 ◽  
Author(s):  
Narasimharao Bhagavathula ◽  
Andrew W. Hanosh ◽  
Kamalakar C. Nerusu ◽  
Henry Appelman ◽  
Subhas Chakrabarty ◽  
...  
Keyword(s):  
Colon Carcinoma ◽  
Receptor Expression ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
And Function ◽  
E Cadherin

scholarly journals Association of decreased calcium-sensing receptor expression with proliferation of parathyroid cells in secondary hyperparathyroidism

2000 ◽  
Vol 58 (5) ◽  
pp. 1980-1986 ◽  
Author(s):  
Shozo Yano ◽  
Toshitsugu Sugimoto ◽  
Tatsuo Tsukamoto ◽  
Kazuo Chihara ◽  
Akira Kobayashi ◽  
...  
Keyword(s):  
Secondary Hyperparathyroidism ◽  
Receptor Expression ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing

Expression and function of the calcium sensing receptor (CaR) in gastrinomas

2000 ◽  
Vol 118 (4) ◽  
pp. A297
Author(s):  
Stephan U. Goebel ◽  
Paolo L. Peghini ◽  
Paul Goldsmith ◽  
Allen M. Spiegel ◽  
Fathia Gibril ◽  
...  
Keyword(s):  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
And Function

scholarly journals The calcium-sensing receptor and vitamin D receptor expression in tertiary hyperparathyroidism

2006 ◽  
Author(s):  
Tomasz Grzela ◽  
Witold Chudzinski ◽  
Zofia Lasiecka ◽  
Justyna Niderla ◽  
Grzegorz Wilczynski ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Receptor Expression ◽  
Calcium Sensing Receptor ◽  
Tertiary Hyperparathyroidism ◽  
Calcium Sensing
Sign in / Sign up

Export Citation Format

Share Document