Diffuse Optical Tomography and Positron Emission Tomography of Human Breast

2006 ◽  
Author(s):  
Soren D. Konecky ◽  
Rony Wiener ◽  
Regine Choe ◽  
Alper Corlu ◽  
Kijoon Lee ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Emission Tomography ◽  
Human Breast ◽  
Positron Emission

scholarly journals Comparison of diffuse optical tomography of human breast with whole-body and breast-only positron emission tomography

2008 ◽  
Vol 35 (2) ◽  
pp. 446-455 ◽  
Author(s):  
Soren D. Konecky ◽  
Regine Choe ◽  
Alper Corlu ◽  
Kijoon Lee ◽  
Rony Wiener ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Emission Tomography ◽  
Whole Body ◽  
Human Breast ◽  
Positron Emission

scholarly journals Co-registration of glucose metabolism with positron emission tomography and vascularity with fluorescent diffuse optical tomography in mouse tumors

2012 ◽  
Vol 2 (1) ◽  
pp. 19 ◽  
Author(s):  
Xiao Tong ◽  
Anikitos Garofalakis ◽  
Albertine Dubois ◽  
Raphaël Boisgard ◽  
Frédéric Ducongé ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Glucose Metabolism ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Emission Tomography ◽  
Mouse Tumors ◽  
Positron Emission

scholarly journals The Synthesis and Evaluations of the68Ga-Lissamine Rhodamine B (LRB) as a New Radiotracer for Imaging Tumors by Positron Emission Tomography

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Xuena Li ◽  
Yafu Yin ◽  
Bulin Du ◽  
Na Li ◽  
Yaming Li
Keyword(s):  
Positron Emission Tomography ◽  
Rhodamine B ◽  
Radiochemical Purity ◽  
Dynamic Imaging ◽  
Emission Tomography ◽  
Tumor Uptake ◽  
Human Breast ◽  
Positron Emission ◽  
Breast Cancer Xenografts ◽  
Mcf 7

Purpose. The aim of this study is to synthesize and evaluate68Ga-labeled Lissamine Rhodamine B (LRB) as a new radiotracer for imaging MDA-MB-231 and MCF-7 cells induced tumor mice by positron emission tomography (PET).Methods. Firstly, we performed the radio synthesis and microPET imaging of68Ga(DOTA-LRB) in athymic nude mice bearing MDA-MB-231 and MCF-7 human breast cancer xenografts. Additionally, the evaluations of18F-fluorodeoxyglucose (FDG), as a glucose metabolism radiotracer for imaging tumors in the same xenografts, have been conducted as a comparison.Results. The radiochemical purity of68Ga(DOTA-LRB) was >95%. MicroPET dynamic imaging revealed that the uptake of68Ga(DOTA-LRB) was mainly in normal organs, such as kidney, heart, liver, and brain and mainly excreted from kidney. The MDA-MB-231 and MCF-7 tumors were not clearly visible in PET images at 5, 15, 30, 40, 50, and 60 min after injection of68Ga(DOTA-LRB). The tumor uptake values of18F-FDG were3.79±0.57and1.93±0.48%ID/g in MDA-MB-231 and MCF-7 tumor xenografts, respectively.Conclusions.68Ga(DOTA-LRB) can be easily synthesized with high radiochemical purity and stability; however, it may be not an ideal PET radiotracer for imaging of MDR-positive tumors.

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