scholarly journals Is Mandatory Prospective Trial Registration Working to Prevent Publication of Unregistered Trials and Selective Outcome Reporting? An Observational Study of Five Psychiatry Journals That Mandate Prospective Clinical Trial Registration

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0133718 ◽  
Author(s):  
Amelia Scott ◽  
Julia J. Rucklidge ◽  
Roger T. Mulder
Keyword(s):  
Clinical Trial ◽  
Observational Study ◽  
Prospective Trial ◽  
Trial Registration ◽  
Prospective Clinical Trial ◽  
Selective Outcome Reporting ◽  
Clinical Trial Registration ◽  
Outcome Reporting

Awareness of clinical trial registration among healthcare professionals: An observational study

2018 ◽  
Vol 11 (4) ◽  
pp. 227-232 ◽  
Author(s):  
Udaya K. Ranawaka ◽  
Ashwini de Abrew ◽  
Manujasri Wimalachandra ◽  
Chandanie A. Wanigatunge ◽  
Lalani C. Rajapakse ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Observational Study ◽  
Healthcare Professionals ◽  
Trial Registration ◽  
Clinical Trial Registration

scholarly journals Clinical Trial Registration in Physical Therapy Journals: A Cross-Sectional Study

2014 ◽  
Vol 94 (1) ◽  
pp. 83-90 ◽  
Author(s):  
Abraham Samuel Babu ◽  
Sundar Kumar Veluswamy ◽  
Pratiksha Tilak Rao ◽  
Arun G. Maiya
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Physical Therapy ◽  
Prospective Trial ◽  
Theory And Practice ◽  
Trial Registration ◽  
Clinical Trial Registration ◽  
Cross Sectional ◽  
Editorial Policies ◽  
Journal Editors

Background Clinical trial registration has become an important part of editorial policies of various biomedical journals, including a few physical therapy journals. However, the extent to which editorial boards enforce the need for trial registration varies across journals. Objective The purpose of this study was to identify editorial policies and reporting of trial registration details in MEDLINE-indexed English-language physical therapy journals. Design This study was carried out using a cross-sectional design. Methods Editorial policies on trial registration of MEDLINE-indexed member journals of the International Society of Physiotherapy Journal Editors (ISPJE) (Journal of Geriatric Physical Therapy, Journal of Hand Therapy, Journal of Neurologic Physical Therapy, Journal of Orthopaedic and Sports Physical Therapy, Journal of Physiotherapy [formerly Australian Journal of Physiotherapy], Journal of Science and Medicine in Sport, Manual Therapy, Physical Therapy, Physical Therapy in Sport, Physiotherapy, Physiotherapy Research International, Physiotherapy Theory and Practice, and Revista Brasileira de Fisioterapia) were reviewed in April 2013. Full texts of reports of clinical trials published in these journals between January 1, 2008, and December 31, 2012, were independently assessed for information on trial registration. Results Among the 13 journals, 8 recommended trial registration, and 6 emphasized prospective trial registration. As of April 2013, 4,618 articles were published between January 2008 and December 2012, of which 9% (417) were clinical trials and 29% (121/417) of these reported trial registration details. A positive trend in reporting of trial registration was observed from 2008 to 2012. Limitations The study was limited to MEDLINE-indexed ISPJE member journals. Conclusions Editorial policies on trial registration of physical therapy journals and a rising trend toward reporting of trial registration details indicate a positive momentum toward trial registration. Physical therapy journal editors need to show greater commitment to prospective trial registration to make it a rule rather than an option.

scholarly journals MEBO versus topical Diltiazem versus a combination of both ointments in the treatment of acute anal fissure: a randomized clinical trial protocol

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mohamad Hadi El Charif ◽  
Samer Doughan ◽  
Rawya Kredly ◽  
Sara Kassas ◽  
Rayan Azab ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Wound Healing ◽  
Anal Fissure ◽  
Topical Therapy ◽  
Trial Registration ◽  
Clinical Trial Registration ◽  
Anal Fissures ◽  
Link Type ◽  
Anorectal Region ◽  
Registration Date

Abstract Background Anal fissure is a common complication of the anorectal region and one of the most reported causes of anal pain. Acute anal fissure can be cured by surgery or medical treatment. There is an increase in the use of topical therapy for the treatment of anal fissures. A common topical drug used is Diltiazem (DTZ), a calcium-channel blocker, which relaxes the anal sphincter and thus promotes healing of the anal fissure. Moist exposed burn ointment (MEBO) is an ointment that is effective for the treatment of burns and wound healing and is becoming popular in the treatment of anal fissures. Methods This is a 1:1:1 randomized, controlled, parallel design, with endpoint measures of change in pain score, wound healing, defecation strain score and patient’s global impression of improvement. The study will be conducted at AUBMC over a 10-week period. Patients will be randomized to three treatment arms: MEBO, Diltiazem, and a combination of MEBO and Diltiazem ointments. Discussion The results of this study will allow physicians to assess the efficacy and safety of MEBO in the treatment of acute anal fissure, and also in comparison to Diltiazem. This trial will generate evidence-based conclusions regarding the use of a herbal/natural-based product (MEBO ointment) for the treatment of anal fissures. Trial registration ClinicalTrials.gov Identifier NCT04153032. Clinical Trial Registration Date: 06-NOVEMBER-2019.

Clinical Trial Registration: The Time Has Come…

PM&R ◽  
2015 ◽  
Vol 7 (12) ◽  
pp. 1203-1204 ◽  
Author(s):  
Leighton Chan ◽  
Allen W. Heinemann
Keyword(s):  
Clinical Trial ◽  
Trial Registration ◽  
Clinical Trial Registration
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