Use of epinephrine with local anesthesia in hypertensive patients I. Blood pressure and pulse rate observations in the waiting room

1957 ◽  
Vol 55 (6) ◽  
pp. 761-774 ◽  
Author(s):  
E. Cheraskin ◽  
T. Prasertsuntarasai
1976 ◽  
Vol 51 (s3) ◽  
pp. 497s-499s ◽  
Author(s):  
E. A. Rosei ◽  
P. M. Trust ◽  
J. J. Brown ◽  
R. Fraser ◽  
A. F. Lever ◽  
...  

1. Labetalol, a compound with both α- and β-adrenoreceptor-blocking actions, was given intravenously (1·5–2·0 mg/kg) in twenty recumbent hypertensive patients. 2. There was a rapid reduction in systolic and diastolic pressures in all, maintained up to 24 h in some subjects. 3. Severe hypotension was not seen in recumbent subjects, but postural hypotension was common. 4. Labetalol caused significant lowering of heart rate. 5. Labetalol induced significant and related lowering of plasma angiotensin II and aldosterone concentrations, most obviously when these were initially high. 6. In a cross-over comparison in five patients against 10 mg of propranolol intravenously, labetalol was more effective in lowering blood pressure, but less effective in lowering pulse rate or plasma angiotensin II.


1982 ◽  
Vol 63 (s8) ◽  
pp. 403s-405s ◽  
Author(s):  
S. Freestone ◽  
L. E. Ramsay

1. Patients with mild hypertension who habitually smoked cigarettes and consumed caffeine were examined after abstaining from caffeine and cigarettes overnight. Their mean blood pressure (147/89 mmHg) was substantially lower than values recorded in the clinic (164/102 mmHg) and remained so when they continued to abstain (149/94 mmHg at 2 h). 2. Smoking two cigarettes (3.4 mg of nicotine) elevated blood pressure by 10/8 mmHg but for only 15 min. 3. Drinking coffee (200 mg of caffeine) elevated blood pressure by up to 10/7 mmHg between 1 and 2 h. 4. Combined coffee and cigarette smoking caused a sustained rise in blood pressure from 5 to 120 min to levels similar to those measured in the clinic (162/102 mmHg at 2 h). The interaction of coffee and cigarettes on blood pressure, but not on pulse rate, was significant. 5. Caffeine ingestion with or without smoking may be important in the genesis of mild hypertension.


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