Review of "Partial deletion of alpha satellite DNA associated with reduced amounts of the centromere protein CENP-B in a mitotically stable human chromosome rearrangement."

2015 ◽  
Author(s):  
Thomas Liehr
Keyword(s):  
Human Chromosome ◽  
Satellite Dna ◽  
Chromosome Rearrangement ◽  
Alpha Satellite ◽  
Partial Deletion ◽  
Alpha Satellite Dna ◽  
Centromere Protein

scholarly journals Partial deletion of alpha satellite DNA associated with reduced amounts of the centromere protein CENP-B in a mitotically stable human chromosome rearrangement.

1990 ◽  
Vol 10 (12) ◽  
pp. 6374-6380 ◽  
Author(s):  
R Wevrick ◽  
W C Earnshaw ◽  
P N Howard-Peebles ◽  
H F Willard
Keyword(s):  
Human Chromosome ◽  
Satellite Dna ◽  
Centromeric Region ◽  
Chromosome Rearrangement ◽  
Specific Antigen ◽  
Chromosome 17 ◽  
Alpha Satellite ◽  
Protein Antigens ◽  
Alpha Satellite Dna ◽  
Human Chromosome 17

A familial, constitutionally rearranged human chromosome 17 is deleted for much of the DNA in its centromeric region but retains full mitotic centromere activity. Fluorescence in situ hybridization, pulsed-field gel electrophoresis, and Southern blot analysis of the residual centromeric region revealed a approximately 700-kb centromeric array of tandemly repeated alpha satellite DNA that was only approximately 20 to 30% as large as a normal array. This deletion was associated with a reduction in the amount of the centromere-specific antigen CENP-B detected by indirect immunofluorescence. The coincidence of the primary constriction, the small residual array of alpha satellite DNA, and the reduced amount of detectable CENP-B support the hypothesis that CENP-B is associated with alpha satellite DNA. Furthermore, the finding that both the deleted chromosome 17 and its derivative supernumerary fragment retained mitotic function and possess centromeric protein antigens suggests that human centromeres are structurally and functionally repetitive.

Partial deletion of alpha satellite DNA associated with reduced amounts of the centromere protein CENP-B in a mitotically stable human chromosome rearrangement

1990 ◽  
Vol 10 (12) ◽  
pp. 6374-6380
Author(s):  
R Wevrick ◽  
W C Earnshaw ◽  
P N Howard-Peebles ◽  
H F Willard
Keyword(s):  
Human Chromosome ◽  
Satellite Dna ◽  
Centromeric Region ◽  
Chromosome Rearrangement ◽  
Specific Antigen ◽  
Chromosome 17 ◽  
Alpha Satellite ◽  
Protein Antigens ◽  
Alpha Satellite Dna ◽  
Human Chromosome 17

A familial, constitutionally rearranged human chromosome 17 is deleted for much of the DNA in its centromeric region but retains full mitotic centromere activity. Fluorescence in situ hybridization, pulsed-field gel electrophoresis, and Southern blot analysis of the residual centromeric region revealed a approximately 700-kb centromeric array of tandemly repeated alpha satellite DNA that was only approximately 20 to 30% as large as a normal array. This deletion was associated with a reduction in the amount of the centromere-specific antigen CENP-B detected by indirect immunofluorescence. The coincidence of the primary constriction, the small residual array of alpha satellite DNA, and the reduced amount of detectable CENP-B support the hypothesis that CENP-B is associated with alpha satellite DNA. Furthermore, the finding that both the deleted chromosome 17 and its derivative supernumerary fragment retained mitotic function and possess centromeric protein antigens suggests that human centromeres are structurally and functionally repetitive.

Ordered mapping of three alpha satellite DNA subsets on human chromosome 22

1995 ◽  
Vol 3 (2) ◽  
pp. 124-127 ◽  
Author(s):  
Rachele Antonacci ◽  
Mariano Rocchi ◽  
Nicoletta Archidiacono ◽  
Antonio Baldini
Keyword(s):  
Human Chromosome ◽  
Satellite Dna ◽  
Chromosome 22 ◽  
Alpha Satellite ◽  
Alpha Satellite Dna

Detection of novel centromeric polymorphisms associated with alpha satellite DNA from human chromosome 11

1987 ◽  
Vol 77 (2) ◽  
pp. 151-156 ◽  
Author(s):  
John S. Waye ◽  
Gillian M. Greig ◽  
Huntington F. Willard
Keyword(s):  
Human Chromosome ◽  
Satellite Dna ◽  
Alpha Satellite ◽  
Chromosome 11 ◽  
Alpha Satellite Dna

Chromosome-specific alpha satellite DNA: Isolation and mapping of a polymorphic alphoid repeat from human chromosome 10

Genomics ◽  
1988 ◽  
Vol 3 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Peter Devilee ◽  
Tim Kievits ◽  
John S. Waye ◽  
Peter L. Pearson ◽  
Huntington F. Willard
Keyword(s):  
Human Chromosome ◽  
Satellite Dna ◽  
Dna Isolation ◽  
Alpha Satellite ◽  
Chromosome 10 ◽  
Alpha Satellite Dna

Organization and evolution of alpha satellite DNA from human chromosome 11

Chromosoma ◽  
1987 ◽  
Vol 95 (3) ◽  
pp. 182-188 ◽  
Author(s):  
John S. Waye ◽  
Leslie A. Creeper ◽  
Huntington F. Willard
Keyword(s):  
Human Chromosome ◽  
Satellite Dna ◽  
Alpha Satellite ◽  
Chromosome 11 ◽  
Alpha Satellite Dna

Cloning and Comparative Mapping of a Human Chromosome 4-Specific Alpha Satellite DNA Sequence

Genomics ◽  
1993 ◽  
Vol 18 (2) ◽  
pp. 230-235 ◽  
Author(s):  
L. D'Aiuto ◽  
R. Antonacci ◽  
R. Marzella ◽  
N. Archidiacono ◽  
M. Rocchi
Keyword(s):  
Human Chromosome ◽  
Dna Sequence ◽  
Satellite Dna ◽  
Comparative Mapping ◽  
Chromosome 4 ◽  
Alpha Satellite ◽  
Alpha Satellite Dna ◽  
Human Chromosome 4
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