scholarly journals VACCINATION IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: RESULTS AND PROSPECTS

2018 ◽  
Vol 56 (3) ◽  
pp. 373-379 ◽  
Author(s):  
B. S. Belov ◽  
S. K. Solovyev ◽  
G. M. Tarasova ◽  
E. A. Aseeva
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Clinical Practice ◽  
Lupus Erythematosus ◽  
Biological Agents ◽  
Systemic Lupus ◽  
Cardinal Directions

The importance of comorbid infections in rheumatology has increased substantially in recent years, particularly in connection with the introduction of biological agents into clinical practice. One of the ways to solve this problem is to study and actively use vaccines. This review deals with the issues related to the use of vaccines against various infections in patients with systemic lupus erythematosus. It discusses the safety and immunogenicity of vaccination, including the use of adjuvant vaccines. Cardinal directions for future investigations of the problem are denoted.

Clinical practice guidelines and recommendations for the management of patients with systemic lupus erythematosus: a critical comparison

Rheumatology ◽  
2020 ◽  
Vol 59 (12) ◽  
pp. e165-e168
Author(s):  
Ariel Izcovich ◽  
Graciela S Alarcón ◽  
José A Gómez-Puerta ◽  
Guillermo J Pons-Estel ◽  
Manuel F Ugarte-Gil ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Clinical Practice ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Critical Comparison ◽  
Guidelines And Recommendations

Clinical Practice Guidelines for the Treatment of Systemic Lupus Erythematosus by the Mexican College of Rheumatology

2019 ◽  
Vol 15 (1) ◽  
pp. 3-20
Author(s):  
Daniel Xibillé-Friedmann ◽  
Marcela Pérez-Rodríguez ◽  
Sandra Carrillo-Vázquez ◽  
Everardo Álvarez-Hernández ◽  
Francisco Javier Aceves ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Clinical Practice ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Lupus Erythematosus ◽  
Systemic Lupus

Medication Use in Systemic Lupus Erythematosus

2010 ◽  
Vol 38 (2) ◽  
pp. 271-274 ◽  
Author(s):  
SASHA BERNATSKY ◽  
CHRISTINE PESCHKEN ◽  
PAUL R. FORTIN ◽  
CHRISTI A. PINEAU ◽  
MURRAY B. UROWITZ ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Clinical Practice ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Independent Predictor ◽  
Immunosuppressive Agents ◽  
Medication Use ◽  
Systemic Lupus ◽  
Antimalarial Agents ◽  
Race Ethnicity

Objective.To evaluate factors affecting therapeutic approaches used in clinical practice for the management of systemic lupus erythematosus (SLE), in a multicenter cohort.Methods.We combined data from 10 clinical adult SLE cohort registries in Canada. We used multivariate generalized estimating equation methods to model dichotomized outcomes, running separate regressions where the outcome was current exposure of the patient to specific medications. Potential predictors of medication use included demographic (baseline age, sex, residence, race/ethnicity) and clinical factors (disease duration, time-dependent damage index scores, and adjusted mean SLE Disease Activity Index-2K scores). The models also adjusted for clustering by center.Results.Higher disease activity and damage scores were each independent predictors of exposure to nonsteroid immunosuppressive agents, and for exposure to prednisone. This was not definitely demonstrated for antimalarial agents. Older age at diagnosis was independently and inversely associated with exposure to any of the agents studied (immunosuppressive agents, prednisone, and antimalarial agents). An additional independent predictor of prednisone exposure was black race/ethnicity (adjusted RR 1.46, 95% CI 1.18, 1.81). For immunosuppressive exposure, an additional independent predictor was race/ethnicity, with greater exposure among Asians (RR 1.39, 95% CI 1.02, 1.89) and persons identifying themselves as First Nations/Inuit (2.09, 95% CI 1.43, 3.04) than among whites. All of these findings were reproduced when adjustment for disease activity was limited to renal involvement.Conclusion.Ours is the first portrayal of determinants of clinical practice patterns in SLE, and offers interesting real-world insights. Further work, including efforts to determine how differing clinical approaches may influence outcome, is in progress.

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