scholarly journals Immunoglobulin G4 Related-Disease: A Rare Presentation With Secondary Hypereosinophilic Syndrome and Eosinophilic Ascites

2021 ◽  
Vol 12 (3) ◽  
pp. 107-111
Author(s):  
Luisa Serpa Pinto ◽  
Nuno Jorge Lamas ◽  
Ana Campar ◽  
Alvaro Ferreira ◽  
Ana Rita Cruz
Keyword(s):  
Hypereosinophilic Syndrome ◽  
Rare Presentation ◽  
Immunoglobulin G4 ◽  
Related Disease ◽  
Eosinophilic Ascites

scholarly journals Isolated middle mediastinal mass associated with immunoglobulin G4-related disease

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Haruaki Hino ◽  
Noriyuki Tanaka ◽  
Hiroshi Matsui ◽  
Takahiro Utsumi ◽  
Natsumi Maru ◽  
...  
Keyword(s):  
Male Patient ◽  
Plasma Cell ◽  
Mediastinal Mass ◽  
Cell Infiltration ◽  
Elderly Male ◽  
Rare Presentation ◽  
Immunoglobulin G4 ◽  
Related Disease ◽  
Plasma Cell Infiltration ◽  
Storiform Fibrosis

Abstract Background Immunoglobulin G4-related disease (IgG4-RD) is a multi-organ disorder predominantly occurring in middle-aged to elderly male patients characterized by multi-organ fibrosis, specific pathological findings of storiform fibrosis with IgG4-positive plasma cell infiltration, and elevated serum IgG4 level. We herein report a rare presentation of IgG4-RD forming an isolated mass in the middle mediastinum mimicking a mediastinal tumor and discuss the clinical significance of mediastinal IgG4-RD. Case presentation An 82-year-old male patient without any symptom was referred due to left middle mediastinal mass (3.8 × 2.4 cm). Because of suspected lymphoma, Castleman’s disease, and lymphangitis due to tuberculosis, we performed a thoracoscopic resection for diagnosis and treatment. The mass was yellowish white with well-encapsulated, and storiform fibrosis with plasma cell infiltration, and obliterative phlebitis were observed microscopically. Additional immunohistochemical stain revealed IgG4-RD. Other radiological findings and serological results did not show evidence of other organs being affected from IgG4-RD nor autoimmune diseases. He is now followed at outpatient clinic without additional treatment for over a year, and an enhanced computed tomography does not show any recurrence. Conclusion It was a rare presentation of IgG4-RD forming isolated middle mediastinal mass, which suggests that we might suspect IgG4-RD for undetermined mediastinal mass in case of middle to elderly male patient.

FDG PET/CT in Isolated Mediastinal Immunoglobulin G4–Related Disease

2020 ◽  
Vol 45 (4) ◽  
pp. e195-e197
Author(s):  
Vankadari Kousik ◽  
Rajender Kumar ◽  
Bhagwant Rai Mittal ◽  
Divya Aggarwal ◽  
Ashutosh Nath Aggarwal
Keyword(s):  
Fdg Pet ◽  
Immunoglobulin G4 ◽  
Related Disease ◽  
Pet Ct ◽  
Fdg Pet Ct

scholarly journals Evaluate the Differences in CT Features and Serum IgG4 Levels between Lymphoma and Immunoglobulin G4-Related Disease of the Orbit

2020 ◽  
Vol 9 (8) ◽  
pp. 2425
Author(s):  
Wei-Hsin Yuan ◽  
Anna Fen-Yau Li ◽  
Shu-Yi Yu ◽  
Ying-Yuan Chen ◽  
Chia-Hung Wu ◽  
...  
Keyword(s):  
Elevated Serum ◽  
Hounsfield Unit ◽  
Immunoglobulin G4 ◽  
Related Disease ◽  
Serum Igg4 ◽  
Orbital Lymphoma ◽  
Serum Igg Levels ◽  
Igg Level ◽  
Ct Features ◽  
Higher Sensitivity

Background: Benign immunoglobulin G4 (IgG4)-related orbital disease (IgG4-ROD)—characterized as tumors mimicking malignant orbital lymphoma (OL)—responds well to steroids, instead of chemotherapy, radiotherapy and/or surgery of OL. The objective of this study was to report the differences in computed tomography (CT) features and- serum IgG4 levels of IgG4-ROD and OL. Methods: This study retrieved records for patients with OL and IgG4-ROD from a pathology database during an eight-year-and-five-month period. We assessed the differences between 16 OL patients with 27 lesions and nine IgG4-ROD patients with 20 lesions according to prebiopsy CT features of lesions and prebiopsy serum IgG4 levels and immunoglobulin G (IgG) levels This study also established the receiver-operating curves (ROC) of precontrast and postcontrast CT Hounsfield unit scales (CTHU), serum IgG4 levels, serum IgG levels and their ratios. Results: Significantly related to IgG4-ROD (all p < 0.05) were the presence of lesions with regular borders, presence of multiple lesions—involving both lacrimal glands on CT scans—higher median values of postcontrast CTHU, postcontrast CTHU/precontrast CTHU ratios, serum IgG4 levels and serum IgG4/IgG level ratios. Compared to postcontrast CTHU, serum IgG4 levels had a larger area under the ROC curve (0.847 [95% confidence interval (CI): 0.674–1.000, p = 0.005] vs. 0.766 [95% CI: 0.615–0.917, p = 0.002]), higher sensitivity (0.889 [95% CI: 0.518–0.997] vs. 0.75 [95% CI: 0.509–0.913]), higher specificity (0.813 [95% CI: 0.544–0.960] vs. 0.778 [95% CI: 0.578–0.914]) and a higher cutoff value (≥132.5 mg/dL [milligrams per deciliter] vs. ≥89.5). Conclusions: IgG4-ROD showed distinct CT features and elevated serum IgG4 (≥132.5 mg/dL), which could help distinguish IgG4-ROD from OL.

Immunoglobulin G4–related disease of the paratestis: Can we avoid radical treatment?

2020 ◽  
pp. 205141582098277
Author(s):  
Thomas Thompson ◽  
Thomas Brophy ◽  
Mohsin Uddin ◽  
James Bolton ◽  
Richard Napier-Hemy
Keyword(s):  
Immunoglobulin G4 ◽  
Related Disease ◽  
Radical Treatment

Sonographic Appearance of the Submandibular Glands in Patients With Immunoglobulin G4-Related Disease

2012 ◽  
Vol 31 (3) ◽  
pp. 489-493 ◽  
Author(s):  
Satomi Asai ◽  
Kenji Okami ◽  
Naoya Nakamura ◽  
Shuichi Shiraishi ◽  
Tomohiro Yamashita ◽  
...  
Keyword(s):  
Immunoglobulin G4 ◽  
Sonographic Appearance ◽  
Submandibular Glands ◽  
Related Disease

Immunoglobulin G4–Related Disease Presenting as Bilateral Arthritis of the Hip Joints

2018 ◽  
Vol 24 (7) ◽  
pp. 398-401 ◽  
Author(s):  
Zhongping Zhan ◽  
Minxi Lao ◽  
Zheng Yang ◽  
Dongying Chen ◽  
Xiuyan Yang
Keyword(s):  
Hip Joints ◽  
Immunoglobulin G4 ◽  
Related Disease

Non-demarcated nodular and flat lesion in the oropharynx associated with immunoglobulin G4-related disease

2022 ◽  
Author(s):  
Yuichi Shimodate ◽  
Kenji Notohara ◽  
Motowo Mizuno
Keyword(s):  
Immunoglobulin G4 ◽  
Related Disease

Immunoglobulin G4-Related Disease Arising from the Bladder Wall

2018 ◽  
Vol 103 (4) ◽  
pp. 488-490 ◽  
Author(s):  
Ryohei Kufukihara ◽  
Naoya Niwa ◽  
Ryuichi Mizuno ◽  
Kentaro Ohara ◽  
Shuji Mikami ◽  
...  
Keyword(s):  
Bladder Wall ◽  
Immunoglobulin G4 ◽  
Related Disease

scholarly journals Immunoglobulin G4-related disease: autoimmune pancreatitis and extrapancreatic manifestations

2016 ◽  
Vol 49 (2) ◽  
pp. 122-125 ◽  
Author(s):  
Daniel Alvarenga Fernandes ◽  
Ricardo Yoshio Zanetti Kido ◽  
Ricardo Hoelz de Oliveira Barros ◽  
Daniel Lahan Martins ◽  
Thiago José Penachim ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Magnetic Resonance ◽  
Autoimmune Disease ◽  
Systemic Autoimmune Disease ◽  
Imaging Findings ◽  
Resonance Imaging ◽  
Immunoglobulin G4 ◽  
Related Disease ◽  
Igg4 Related Disease

Abstract We present a case of immunoglobulin G4 (IgG4)-related disease with pancreatic and extrapancreatic involvement, including the biliary and renal systems. Given the importance of imaging methods for the diagnosis of IgG4-related disease and its differentiation from pancreatic adenocarcinoma, we emphasize important abdominal computed tomography and magnetic resonance imaging findings related to this recently recognized systemic autoimmune disease.

Immunoglobulin G4-Related Disease Association With an Isolated Anterior Mediastinal Tumor

2019 ◽  
Vol 107 (6) ◽  
pp. e405-e407
Author(s):  
Ryohei Yoshikawa ◽  
Hitoshi Igai ◽  
Fumi Ohsawa ◽  
Tomohiro Yazawa ◽  
Mitsuhiro Kamiyoshihara
Keyword(s):  
Mediastinal Tumor ◽  
Disease Association ◽  
Immunoglobulin G4 ◽  
Related Disease ◽  
Anterior Mediastinal Tumor
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