Einige Gold(I)-Komplexe von Phosphor-yliden und ihre Wirkung in der Gold-Therapie am Modell der Adjuvans-Arthritis /Some Gold(I) Complexes of Phosphorus Ylides and their Effect in Gold Therapy with the Adjuvans Arthritis Model

1978 ◽  
Vol 33 (11) ◽  
pp. 1325-1329 ◽  
Author(s):  
Hubert Schmidbaur ◽  
Johann R. Mandl ◽  
Anette Wohlleben ◽  
Armin Fügner
Keyword(s):  
Spectroscopic Data ◽  
Pharmacological Study ◽  
Phosphorus Ylides ◽  
Gold Therapy ◽  
Arthritis Model ◽  
Phosphorus Ylide ◽  
Preliminary Study ◽  
Ylide Complexes

Abstract A series of ionic phosphorus ylide complexes of gold(I) halides has been prepared and characterized through analytical and spectroscopic data. The compounds are of the type [R3PAu-CH2PR3]⊕Cl⊖, R = C2H5, and [(R3PCH2)2Au]⊕X⊖ where R = CH3, C2H5, n-C4H9, C6H5, and X = Cl, Br (1-6). Along with a cyclic complex [(C2H5)2P(CH2)2Au]2 (7) these materials have been tested in a pharmacological study for a possible use in an oral arthritis therapy.Compounds 1 and 5-7 showed no or only neglegible effects on Adjuvans-arthritis induced in rats, while 3 and 4 were very toxic. Complex 2 was comparable to standard chrysotherapeutic agent3 in a preliminary study, but a more detailed investigation including LD50 tests for mice showed too narrow a gap between its toxical and therapeutically useful doses.

scholarly journals CHELATE PHOSPHORUS YLIDE COMPLEXES OF PALLADIUM AND PLATINUM

1975 ◽  
Vol 4 (12) ◽  
pp. 1259-1260 ◽  
Author(s):  
Yoshinao Oosawa ◽  
Taro Saito ◽  
Yukiyoshi Sasaki
Keyword(s):  
Phosphorus Ylide ◽  
Ylide Complexes

Lewis Acid Catalysis with Cationic Dinuclear Gold(II,II) and Gold(III,III) Phosphorus Ylide Complexes

2016 ◽  
Vol 35 (17) ◽  
pp. 2830-2835 ◽  
Author(s):  
Benjamin R. Reiner ◽  
Mark W. Bezpalko ◽  
Bruce M. Foxman ◽  
Casey R. Wade
Keyword(s):  
Lewis Acid ◽  
Acid Catalysis ◽  
Lewis Acid Catalysis ◽  
Phosphorus Ylide ◽  
Ylide Complexes

Einige neue Iridium-Komplexe von Phosphor-yliden /Some New Iridium Complexes of Phosphorus Ylides

1979 ◽  
Vol 34 (9) ◽  
pp. 1218-1220 ◽  
Author(s):  
T. E. Fraser ◽  
H.-J. Fuller ◽  
H. Schmidbaur
Keyword(s):  
Spectroscopic Data ◽  
Iridium Complexes ◽  
Phosphorus Ylides ◽  
Simple Addition ◽  
Cyclic Complexes

Abstract From the iridium complexes [(1,5-C8H12)IrCl]2, [(C8H14)2IrCl]2 and [(C6H5)3P]2lr(CO)Cl, and the ylides (CH3)3P = CH2 and (CH3)3P = N-P(CH3)2 = CH2, a number of organoiridium compounds has been synthesized. Whereas with (CH3)3P = CH2 the transylidation reaction is very slow and simple addition with formation of sparingly soluble products prevails, the double ylide forms cyclic complexes quite readily. These ylide chelates were characterized by analytical and spectroscopic data.

Novel vanadium and titanium phosphorus ylide complexes

1996 ◽  
pp. 779 ◽  
Author(s):  
Pietro Berno ◽  
Sandro Gambarotta ◽  
Sirpa Kotila ◽  
Gerhard Erker
Keyword(s):  
Phosphorus Ylide ◽  
Ylide Complexes

Übergangsmetallkomplexe instabiler Ylide, IX [1] Zur Reaktivität von Pentacarbonyl(dimethyloxosulfoniomethanid)chrom(0) gegenüber Organoelementmethyldiphenylphosphanen RnECH2PPh2 (ERn = Ph2Sb, MeS, PhS, PhSe) und (RnE)2CH2 (RnE = Ph2Sb, MeS)

1985 ◽  
Vol 40 (7) ◽  
pp. 968-974 ◽  
Author(s):  
Lothar Weber ◽  
Dietmar Wewers ◽  
Ewald Lücke
Keyword(s):  
Thermal Reaction ◽  
Chelate Complex ◽  
Phosphorus Ylide ◽  
Sulfur Ylide ◽  
Ylide Complexes

Abstract Treatment of the sulfur ylide complex (CO)5Cr[CH2S(O)Me2] (1) with the bifunctional phosphines Ph2PCH2ERn (ERn = SMe, SPh, SePh) lead to pentacarbonylchromium phosphorus ylide complexes (CO)5CrCH2PPh2CH2ERn. Only the S-methyl derivate could be converted to the metallocycle (CO)4[xxx] (ERn = SMe) by UV-irridiation. The ylide chelate complex (CO)4[xxx]Ph2 is formed directly by the thermal reaction of Ph2PCH2SbPh2 with 1. N o ylide complexes result from the reaction of 1 with (Ph2Sb)2CH2 and (MeS)2CH2. The only products identified were (CO)5Cr[Ph2SbCH2SbPh2] and [(CO)5CrS(Me) - ]2CH2, respectively.

Ylid-Komplexe von Alkali- und Erdalkalimetallen, VI [1] Neutrale und anionische Ferrocenylmethylide und Fluorenylide/Ylide Complexes of Alkali and Earth Alkaline Metals, VI [1] Neutral and Anionic Ferrocenylmethylides and Fluorenylides

1982 ◽  
Vol 37 (8) ◽  
pp. 950-956 ◽  
Author(s):  
Hubert Schmidbaur ◽  
Ulrich Deschler ◽  
Dietmar Seyferth
Keyword(s):  
Nmr Spectra ◽  
Quaternary Salt ◽  
Base Hydrolysis ◽  
Aromatic Rings ◽  
Phosphorus Ylides ◽  
Alkali Cations ◽  
Nmr Spectrum ◽  
Alkali Complexes ◽  
Hydrolysis Of ◽  
Ylide Complexes

Abstract Coordination properties of phosphorus ylides towards electropositive metals are greatly improved in systems, where the carbanionic charge can be delocalized into the aromatic rings of substituents, as illustrated in the title compounds. The ferrocenyl-substituted ylide 2, synthesized from bis(diphenylphosphino)methane and (ferrocenyl)trimethyl-ammonium iodide via the phosphonium salt intermediate 1, is thus easily converted into the alkali complexes 3 a, b on treatment with NaNH2 or KH in tetrahydrofuran, respectively. The intensely coloured products are soluble in a number of organic solvents. NMR spectra of these solutions provide evidence for an interaction between alkali cations and the ferrocenyl rings. - From (C6H5)2CH2P(C6H5)2 and ferrocenylmethyl chloride a di-quaternary salt 4 is obtained, which yields a double-ylide mixture 5 a, b on treatment with base. Hydrolysis of this product affords the ylidic phosphine oxide 6. - The reaction of the ylides 7 and 9 (described previously) with NaNH2, KH or barium metal (in liquid ammonia) leads to the (earth) alkali complexes 8a-c and 10a, b, respectively. With the exception of 8c, but similar to 3a, these materials contain tetrahydrofuran solvate molecules. The 23Na NMR spectrum of 8a and the pronounced quadrupole broadening of the P(III) signals by the alkali cations in the 31P NMR spectra of 8 a, b allow structural suggestions for the solution state as proposed in the formulae. Further treatment of 10b with KH yields a potassium complex 11, characterized, i.a., via a corresponding diquaternary salt 12.

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