MK-5172: a second-generation protease inhibitor for the treatment of hepatitis C virus infection

Expert Opinion on Investigational Drugs ◽

10.1517/13543784.2014.902049 ◽

2014 ◽

Vol 23 (5) ◽

pp. 719-728 ◽

Author(s):

Ivan Gentile ◽

Antonio Riccardo Buonomo ◽

Federico Borgia ◽

Emanuela Zappulo ◽

Giuseppe Castaldo ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Protease Inhibitor ◽

Second Generation ◽

Hepatitis C Virus Infection

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Use of several second generation serological assays to determine the true prevalence of hepatitis C virus infection in haemophiliacs treated with non-virus inactivated factor VIII and IX concentrates

British Journal of Haematology ◽

10.1111/j.1365-2141.1992.tb04566.x ◽

1992 ◽

Vol 80 (4) ◽

pp. 514-518 ◽

Author(s):

Henry G. Watson ◽

Christopher A. Ludlam ◽

Selma Rebus ◽

Lin Qi Zhang ◽

John F. Peutherer ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Factor Viii ◽

Second Generation ◽

Hepatitis C Virus Infection ◽

True Prevalence ◽

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Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Journal of Medicinal Chemistry ◽

10.1021/jm401840s ◽

2014 ◽

Vol 57 (5) ◽

pp. 1708-1729 ◽

Author(s):

Paul M. Scola ◽

Alan Xiangdong Wang ◽

Andrew C. Good ◽

Li-Qiang Sun ◽

Keith D. Combrink ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Protease Inhibitor ◽

Clinical Evaluation ◽

Hepatitis C Virus Infection ◽

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Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c01296 ◽

2020 ◽

Vol 63 (23) ◽

pp. 14740-14760

Author(s):

Li-Qiang Sun ◽

Eric Mull ◽

Stanley D’Andrea ◽

Barbara Zheng ◽

Sheldon Hiebert ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Protease Inhibitor ◽

Third Generation ◽

Hepatitis C Virus Infection

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Practical evaluation of a mouse with chimeric human liver model for hepatitis C virus infection using an NS3-4A protease inhibitor

Journal of General Virology ◽

10.1099/vir.0.019315-0 ◽

2010 ◽

Vol 91 (7) ◽

pp. 1668-1677 ◽

Author(s):

N. Kamiya ◽

E. Iwao ◽

N. Hiraga ◽

M. Tsuge ◽

M. Imamura ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Protease Inhibitor ◽

Human Liver ◽

Hepatitis C Virus Infection ◽

Liver Model ◽

Practical Evaluation

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ChemInform Abstract: Challenges in Modern Drug Discovery: A Case Study of Boceprevir, an HCV Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

10.1002/chin.200817245 ◽

2008 ◽

Vol 39 (17) ◽

Author(s):

F. George Njoroge ◽

Kevin X. Chen ◽

Neng-Yang Shih ◽

John J. Piwinski

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Drug Discovery ◽

Virus Infection ◽

Protease Inhibitor ◽

Hepatitis C Virus Infection ◽

Modern Drug ◽

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Despite poor interferon response in advanced hepatitis C virus infection, models of protease inhibitor treatment predict maximum treatment benefit

Alimentary Pharmacology & Therapeutics ◽

10.1111/apt.12018 ◽

2012 ◽

Vol 36 (7) ◽

pp. 670-679 ◽

Author(s):

I. A. Rowe ◽

D. D. Houlihan ◽

D. J. Mutimer

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Protease Inhibitor ◽

Interferon Response ◽

Hepatitis C Virus Infection ◽

Treatment Benefit ◽

Infection Models ◽

Inhibitor Treatment

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Challenges in Modern Drug Discovery: A Case Study of Boceprevir, an HCV Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Accounts of Chemical Research ◽

10.1021/ar700109k ◽

2008 ◽

Vol 41 (1) ◽

pp. 50-59 ◽

Author(s):

F. George Njoroge ◽

Kevin X. Chen ◽

Neng-Yang Shih ◽

John J. Piwinski

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Drug Discovery ◽

Virus Infection ◽

Protease Inhibitor ◽

Hepatitis C Virus Infection ◽

Modern Drug ◽

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Diagnosis of hepatitis C virus infection using two second-generation enzyme immunoassays with a recombinant immunoblot assay for confirmation

European Journal of Clinical Microbiology & Infectious Diseases ◽

10.1007/bf01982183 ◽

1994 ◽

Vol 13 (2) ◽

pp. 118-121 ◽

Author(s):

P. Schneeberger ◽

H. Nat ◽

W. Dijk ◽

A. Loon

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Second Generation ◽

Hepatitis C Virus Infection ◽

Immunoblot Assay ◽

Enzyme Immunoassays ◽

Recombinant Immunoblot Assay

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Improved Serodiagnosis of Posttransfusion Hepatitis C Virus Infection by a Second-Generation Immunoassay Based on Multiple Recombinant Antigens

Vox Sanguinis ◽

10.1111/j.1423-0410.1992.tb01161.x ◽

1992 ◽

Vol 62 (1) ◽

pp. 21-24 ◽

Author(s):

Jin-Town Wang ◽

Teh-Hong Wang ◽

Jaw-Town Lin ◽

Jin-Chuan Slieu ◽

Cha-Ze Lee ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Second Generation ◽

Hepatitis C Virus Infection ◽

Recombinant Antigens ◽

Posttransfusion Hepatitis

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Hepatitis C virus infection in kidney graft recipients: a study with second-generation assays

Nephrology Dialysis Transplantation ◽

10.1093/oxfordjournals.ndt.a092043 ◽

1992 ◽

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Second Generation ◽

Kidney Graft ◽

Hepatitis C Virus Infection

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