Three new species of Byrsopteryx Flint microcaddisflies from Peru (Insecta: Trichoptera) including DNA-based larval associations

In this paper, we have described and illustrated three new species of Byrsopteryx from Peru: Byrsopteryx inti, sp. nov. Byrsopteryx mamaocllo sp. nov., and Byrsopteryx mancocapac sp. nov. Larvae of the latter two were also associated to male specimens based on comparison of a fragment of COI gene and pharate male identification. Byrsopteryx inti sp. nov. and Byrsopteryx mamaocllo sp. nov. share a unique feature: a semi-dome process formed by a thickened area on male forewings. The three species can be easily identified by wing coloration and male genitalia. Furthermore, Byrsopteryx inti sp. nov. can be recognized by its sternum VIII with a median digitate process on posterior margin, slightly capitate; and by long dorsolateral processes from segment VIII, which cross each other apically in dorsal view. Byrsopteryx mamaocllo sp. nov. can be distinguished by sternum VIII bearing a pair of short, posterior, spinelike processes, which are curved inwards and bordered by a rounded, membranous structure, and by a pair of short, heavily sclerotized, dorsolateral processes. Byrsopteryx mancocapac sp. nov. can be distinguished by strong spine-like processes arising dorsally from subgenital plate and by sternum VIII with posterior margin divided into two plate-like lobes. Larvae of B. mamaocllo sp. nov. and B. mancocapac sp. nov. are similar to other Byrsopteryx larvae known. They can be distinguished from each other by the shape of the operculum formed by terga VIII and IX, and number of setae on the second abdominal pleurite. Maximum likelihood analyses of 20 COI sequences, including nine Byrsopteryx species, placed B. inti sp. nov. and B. mamaocllo sp. nov. as sister species and related to a clade including B. gomezi, B. tapanti, and B. esparta, while B. mancocapac sp. nov. was found as sister to B. abrelata. Despite the close phylogenetic relationship found between B. inti sp. nov. and B. mamaocllo sp. nov., they are separated by 14.9% minimum K2P divergence of COI. The highest intraspecific distance observed was 1.4% for B. mancocapac sp. nov. individuals. Although the Peruvian caddisfly fauna has around 320 known species and almost a third of them are microcaddisflies, in this paper we present the first descriptions of Byrsopteryx species for the country.

Russian recombinant coagulation factors: the technological background and the results of clinical studies

The prolongation of survival and the improvement of quality of life in patients with hemophilia A and B are only possible if hemostatic disorders caused by coagulation factor VIII and IX deficiency are managed effectively. Recombinant coagulation factors are playing an ever-increasing role in the preventive care of affected patients. The development, production and use of domestic recombinant coagulation factors opened up new treatment opportunities and improved access to preventive care for hemophilia patients. The results of clinical studies on the efficacy and safety of the Russian recombinant factors showed that they had similar efficacy and safety compared to the plasma derived clotting factors.

Optimalisasi Kemampuan Guru Melalui Pelatihan Kuis Interaktif Secara Daring Berbasis Teknologi Informasi

The use of technology is very important in learning in the pandemic era. Various efforts were made to equip teachers to optimize the use of learning media. One of these efforts is to organize training on making interactive quizzes based on information technology which is held at SMP Negeri 1 Jaten. This training aims to provide insight related to learning media so that teachers are able to improve their abilities in making interactive quizzes and have a good impact on the future learning process. The method used in this training consists of three stages, namely preparation, implementation and evaluation.This training was conducted on May 6 – May 7, 2021 and was attended by 32 teachers for grades VII, VIII and IX consisting of subject teachers. The result of this training activity is that the teacher understands the training material well so that all the information obtained can be directly put into practice. Teachers get material that is very relevant to the needs in the classroom and can support learning activities. In addition, teachers get new insights related to learning media that can be applied in preparing interactive quizzes creatively and innovatively.

The profile of students HOTS at Malang, Indonesia in responding to higher-thinking biology questions

Higher Order Thinking Skills (HOTS) is one of the primary 21st-century skills that Indonesian schools have not optimally developed. The present study was aimed at 1) presenting the profile of students’ HOTS in Malang and 2) investigating the influence of grades on students’ HOTS. This quantitative study involved 559 students from 18 schools in Malang municipality as the participants. The data were collected using ten essay questions as the instrument and analyzed through descriptive statistics and one-way ANOVA as the data analysis techniques chosen in this study. This study revealed that first, the students of Junior High School in grades VII, VIII, and IX at Malang acquired a low level of HOTS. Second, the students of Senior High School performed an excellent level of HOTS. Third, there was a significant influence of the student's grades to the level of the students’ HOTS in which senior high school students accomplished a higher level HOTS than junior high school students. Therefore, to improve this essential skill, the students in Indonesian schools should be given as much exposure to teaching and assessment based on HOTS.

Peran Ibu dalam Pendidikan Kesehatan Reproduksi, Peran Bidan, Personal Hygine Menstruasi terhadap Kejadian Keputihan pada Remaja Putri

Introduction: Flour albus is a symptom disorders of the reproductive organs often experienced by most women, according to WHO (World Health Organization) 75% of women in the world will experience vaginal discharge at least once in a lifetime and as many as 45% will have 2 or more. This study aims to determine the relations of mother's role in reproductive health education, role of midwife, personal hygine menstruation of the teenage girl flour albus event in class VIII and IX at SMP Muhammadiyah 35 Jakarta Method: This research method uses quantitative research with a cross sectional approach. The study sample used total sampling, namely all the teenage girl in class VIII and IX were 50 people Result: The results showed that there was a relationship between the mother's role in reproductive health education variable and the p-value of 0.003, the role of midwife variable with the result of p-value 0.001 and the variable personal hygine menstruation with a p-value of 0.015 for the teenage girl flour albus event. Discussion: 34 young women who experience vaginal discharge, 27 young women whose mothers do not play a role in health education, 27 young women who do not get the role of a midwife and 32 young women who are not good at performing menstrual personal hygiene. and there is a relationship between the role of mothers in reproductive health with the incidence of vaginal discharge in adolescent girls. In conclusion, it is expected the school to cooperate among parents and health officer, for the reproductive health education, to improve the degree of health and build good reproductive health behaviour, as well as to preventing and handling vaginal discharge in teenage girl.

Evaluation of Factor Viii and Factor IX Activity among Primary School Children in Owerri, Imo State, Nigeria

The values of factor VIII (FVIII) and factor IX (FIX) were evaluated among some primary school children in Owerri zone Imo State. The aim was to assess deficiency state or reduction in activity among these children. A total of two hundred and ten (210) venous blood samples were collected from primary school pupils whose parents consented to, and whose answers to the distributed questionnaires suggested symptoms of haemophilia. The samples were collected from pupils between the ages of five and thirteen years, and from different primary schools to represent different areas of Owerri (Works Layout Area, Nekede Area, Trans Egbu Area, and Akwukuma Area). Samples were preserved using trisodium citrate anticoagulant and transported to the haematology unit of the Federal Medical Centre Owerri within 3 hours for analysis which was done using Rayto semi auto coagulation analyzer RT 2204C with its normal ranges for factor VIII and IX activities as (50% - 200% and 70% - 200%) respectively. Out of the 210 samples collected, 16(7.6%) have <50% of factor VIII activity and 14(6.7%) have <70% of factor IX activity. Akwakuma area produced highest occurrence of factor VIII deficiency (14.8%, 8 pupils) while Works Layout and Trans Egbu Areas produced the least incidence (3.8%, 2 pupils) each. Factor IX deficiency was most prevalent at Trans Egbu Area 6(11.5%) and least at Works Layout 0(0.0%). Six children between the ages of 5 and 7 years had the highest incidence of FVIII deficiency (23.1%), while eight pupils between the ages of 11-13 years showed the highest incidence of FIX deficiency. Eight Females were found to have the highest incidence of both FVIII and FIX deficiencies (8.2% for both defects ), while the males presented a lower incidence of the same defects (7.1%, 8 pupils and 5.4%, 6 pupils respectively). The mean levels of FVIII and FIX in all the pupils evaluated are 78.61 and 89.98 respectively while the standard deviation of the results from the mean are 2.584 and 1.473 for factor VIII and IX respectively. These data show that haemophilia A and B exist in Owerri and considering the danger it portends to lives of the citizenry, Government should provide facilities in our hospitals to take care of the affected pupils to ensure a healthy society.

Pengaruh Penyuluhan Kesehatan Melalui Media Video Terhadap Upaya Pencegahan Penyakit Skabies di Pesantren IMMIM Putra Makassar

The high prevalence of skabies in Islamic boarding schools is due to the limited knowledge, attitudes and behavior. The prevalence of school age suffering from scabies is 64%. The aimed of study was the effect of health education through video of media on efforts to prevent skabies at the Islamic Boarding School IMMIM Putra Makassar. The type of research used is pre-experimental design with a one-group pre-test and post-test design. Samples was 50 respondents using purposive sampling technique consisting of class VIII and IX. Collecting data used was questionnaire. The data were analyzed with wilcoxon test. The results of the pre-test knowledge category 54,0%, low 46,0%, post-test knowledge was high 98.0% and low 2,00%. Pre-test attitude positive 90,0%, negative 10,0%, while the post-test positive attitude 96,0% and negative 4,00%. The pre-test for the category behavior is quite 100,0% while the post-test for the category action is quite 100,0%. The results of p value <0.05 means that there is an effect of health counseling using video media on knowledge (0.000) attitudes (0.000) and behavior (0.002) to santri in an effort to prevent skabies disease. It is hoped that the management of the pesantren can prohibit students from exchanging clothes and beds so that the transmission of skabies does not occur, conduct mass treatment to break the chain of disease, for santri to improve environmental of quality, clean and healthy living on behavior.

Hemophilia therapeutics

Hemophilia is a genetic hemorrhagic condition marked by uncontrollable and persistent bleeding following surgery or trauma. Hemophilia A is the more common of the two, affecting 1:5000 newborn males in the population. Injecting factor replacement treatments are the most common therapy for hemophilia. The drugs that replaced the clotting factors VIII and IX were developed in the 1950s and 60s. They have been used to treat blood transfusions since the mid-1970s. The development of a humanized bispecific antibody (emicizumab; ACE910) that binds to FIX and FX and replicates the action of FVIII was a key breakthrough in hemophilia therapy. The cost of maintaining this antibody is high, and the feasibility of developing antibodies against the reactant has yet to be determined. Gene therapy is a promising alternative.