Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Li-Qiang Sun; Eric Mull; Stanley D’Andrea; Barbara Zheng; Sheldon Hiebert; Eric Gillis; Michael Bowsher; Sarkunam Kandhasamy; Venkata Rao Baratam; Sunitha Puttaswamy; Nagalakshmi Pulicharla; Sureshbabu Vishwakrishnan; Subba Reddy; Ravi Trivedi; Sarmistha Sinha; Sankar Sivaprasad; Abhijith Rao; Salil Desai; Kaushik Ghosh; Rushith Anumula; Amit Kumar; Ramkumar Rajamani; Ying-Kai Wang; Hua Fang; Arvind Mathur; Richard Rampulla; Tatyana A. Zvyaga; Kathy Mosure; Susan Jenkins; Paul Falk; Debarati M. Tagore; Chaoqun Chen; Kishore Rendunchintala; James Loy; Nicholas A. Meanwell; Fiona McPhee; Paul M. Scola

doi:10.1021/acs.jmedchem.0c01296

Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c01296 ◽

2020 ◽

Vol 63 (23) ◽

pp. 14740-14760

Author(s):

Li-Qiang Sun ◽

Eric Mull ◽

Stanley D’Andrea ◽

Barbara Zheng ◽

Sheldon Hiebert ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Protease Inhibitor ◽

Third Generation ◽

Hepatitis C Virus Infection

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Faculty Opinions recommendation of Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.739095985.793580611 ◽

2020 ◽

Author(s):

John Lowe

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Protease Inhibitor ◽

Third Generation ◽

Hepatitis C Virus Infection

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Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Journal of Medicinal Chemistry ◽

10.1021/jm401840s ◽

2014 ◽

Vol 57 (5) ◽

pp. 1708-1729 ◽

Cited By ~ 44

Author(s):

Paul M. Scola ◽

Alan Xiangdong Wang ◽

Andrew C. Good ◽

Li-Qiang Sun ◽

Keith D. Combrink ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Protease Inhibitor ◽

Clinical Evaluation ◽

Hepatitis C Virus Infection ◽

Ns3 Protease

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Hepatitis C virus infection in anti-HIV positive and negative French homosexual men with chronic hepatitis: comparison of second- and third-generation anti-HCV testing

Liver International ◽

10.1111/j.1600-0676.1993.tb00653.x ◽

2008 ◽

Vol 13 (6) ◽

pp. 319-322 ◽

Cited By ~ 20

Author(s):

Patrick Marcellin ◽

Jean-François Colin ◽

Michèle Martinot-Peignoux ◽

Bach-Nga Pham ◽

Valérie Lefort ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Hiv Positive ◽

Homosexual Men ◽

Third Generation ◽

Hepatitis C Virus Infection ◽

Anti Hiv ◽

Hcv Testing

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Indeterminate third-generation recombinant immunoblot assay in hepatitis C virus infection

Journal of Hepatology ◽

10.1016/s0168-8278(94)80150-9 ◽

1994 ◽

Vol 21 (1) ◽

pp. 133-134 ◽

Cited By ~ 7

Author(s):

Jérôme Lamoril ◽

Françoise Lunel ◽

Pierre Laurent-Puig ◽

Christine Defer ◽

Pascale Loiseau ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Third Generation ◽

Hepatitis C Virus Infection ◽

Immunoblot Assay ◽

Recombinant Immunoblot Assay

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Practical evaluation of a mouse with chimeric human liver model for hepatitis C virus infection using an NS3-4A protease inhibitor

Journal of General Virology ◽

10.1099/vir.0.019315-0 ◽

2010 ◽

Vol 91 (7) ◽

pp. 1668-1677 ◽

Cited By ~ 26

Author(s):

N. Kamiya ◽

E. Iwao ◽

N. Hiraga ◽

M. Tsuge ◽

M. Imamura ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Protease Inhibitor ◽

Human Liver ◽

Hepatitis C Virus Infection ◽

Liver Model ◽

Practical Evaluation

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ChemInform Abstract: Challenges in Modern Drug Discovery: A Case Study of Boceprevir, an HCV Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

ChemInform ◽

10.1002/chin.200817245 ◽

2008 ◽

Vol 39 (17) ◽

Author(s):

F. George Njoroge ◽

Kevin X. Chen ◽

Neng-Yang Shih ◽

John J. Piwinski

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Drug Discovery ◽

Virus Infection ◽

Protease Inhibitor ◽

Hepatitis C Virus Infection ◽

Modern Drug ◽

Hcv Protease

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Despite poor interferon response in advanced hepatitis C virus infection, models of protease inhibitor treatment predict maximum treatment benefit

Alimentary Pharmacology & Therapeutics ◽

10.1111/apt.12018 ◽

2012 ◽

Vol 36 (7) ◽

pp. 670-679 ◽

Cited By ~ 4

Author(s):

I. A. Rowe ◽

D. D. Houlihan ◽

D. J. Mutimer

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Protease Inhibitor ◽

Interferon Response ◽

Hepatitis C Virus Infection ◽

Treatment Benefit ◽

Infection Models ◽

Inhibitor Treatment

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Evaluate the antiviral treatment responses in patients with chronic hepatitis C virus infection by third generation anti-HCV assay

Journal of Hepatology ◽

10.1016/s0168-8278(02)80897-2 ◽

2002 ◽

Vol 36 ◽

pp. 249

Author(s):

Tung Hung-Da ◽

Lu Sheng-Nan ◽

Lee Chuan-Mo ◽

Wang Jing-Houng ◽

Chen Tsung-Ming ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Chronic Hepatitis C ◽

Antiviral Treatment ◽

Third Generation ◽

Hepatitis C Virus Infection ◽

Chronic Hepatitis C Virus ◽

Treatment Responses

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Challenges in Modern Drug Discovery: A Case Study of Boceprevir, an HCV Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Accounts of Chemical Research ◽

10.1021/ar700109k ◽

2008 ◽

Vol 41 (1) ◽

pp. 50-59 ◽

Cited By ~ 156

Author(s):

F. George Njoroge ◽

Kevin X. Chen ◽

Neng-Yang Shih ◽

John J. Piwinski

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Drug Discovery ◽

Virus Infection ◽

Protease Inhibitor ◽

Hepatitis C Virus Infection ◽

Modern Drug ◽

Hcv Protease

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MK-5172: a second-generation protease inhibitor for the treatment of hepatitis C virus infection

Expert Opinion on Investigational Drugs ◽

10.1517/13543784.2014.902049 ◽

2014 ◽

Vol 23 (5) ◽

pp. 719-728 ◽

Cited By ~ 26

Author(s):

Ivan Gentile ◽

Antonio Riccardo Buonomo ◽

Federico Borgia ◽

Emanuela Zappulo ◽

Giuseppe Castaldo ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Protease Inhibitor ◽

Second Generation ◽

Hepatitis C Virus Infection

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