Sebastião Rodrigues Ferreira-Filho
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Camila Caetano Cardoso
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Luiz Augusto Vieira de Castro
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Ricardo Mendes Oliveira
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Renata Rodrigues Sá
There are doubts about whether the values obtained from the Cockroft-Gault (ClCG) and Modification of Diet in Renal Disease (GFRMDRD) formulas are comparable to the more traditional formula used to obtain the creatinine clearance from a 24-hour urine collection (ClCrm), particularly in patients with only one kidney. The present study aimed to compare these formulas in individuals with one remaining kidney after previous nephrectomy (Nx) and to verify which estimated formula correlates more closely with ClCrm. Thirty-six patients who had undergone Nx had their renal filtration analyzed with ClCG, GFRMDRDand by ClCrm. The average time after Nx was years, and the average age at the time of the study was years old (X ± SD). The results of three clearances were mL·min·m2for ClCrm, mL·min·m2for ClCrCG, and mL·min·m2for GFRMDRD(with ClCrm> ClCrCGand GFRMDRD; ). No difference was found between the ClCrCGand GFRMDRDvalues (). The data demonstrated that both estimate formulas were strongly correlated with ClCrm, although ClCrCGwas more closely associated with ClCrmthan GFRMDRD(ClCrCGwith and GFRMDRDwith ; ). In conclusion, for people with only one kidney remaining after NX, our data showed that glomerular filtration rate estimation by ClCrCGis more related to the values obtained with the traditional clearance measurement based on a 24-hour urine collection test.
Correlation between cystatin C-based formulas, Schwartz formula and urinary creatinine clearance for glomerular filtration rate estimation in children with kidney disease