scholarly journals Lack of Self-Administration of Cocaine in Dopamine D1 Receptor Knock-Out Mice

2007 ◽  
Vol 27 (48) ◽  
pp. 13140-13150 ◽  
Author(s):  
S. B. Caine ◽  
M. Thomsen ◽  
K. I. Gabriel ◽  
J. S. Berkowitz ◽  
L. H. Gold ◽  
...  
Keyword(s):  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Self Administration ◽  
Knock Out ◽  
Knock Out Mice

scholarly journals Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats

2015 ◽  
Vol 99 ◽  
pp. 689-695 ◽  
Author(s):  
Brandon J. Hall ◽  
Susan Slade ◽  
Cheyenne Allenby ◽  
Munir G. Kutlu ◽  
Edward D. Levin
Keyword(s):  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Self Administration

P.2.23 MDMA self-administration is abolished in serotonin transporter knock-out mice

2007 ◽  
Vol 17 ◽  
pp. S57-S58
Author(s):  
J.M. Trigo-Diaz ◽  
T. Renoir ◽  
L. Lanfumey ◽  
M. Hamon ◽  
K.P. Lesch ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Self Administration ◽  
Knock Out ◽  
Knock Out Mice

l-Stepholidine, a Naturally Occurring Dopamine D1 Receptor Agonist and D2 Receptor Antagonist, Attenuates Methamphetamine Self-Administration in Rats

2014 ◽  
Vol 998-999 ◽  
pp. 169-172 ◽  
Author(s):  
Kai Yue ◽  
Bao Miao Ma ◽  
Jun Qiao Xing ◽  
Xiao Kang Gong ◽  
Qin Ru ◽  
...  
Keyword(s):  
Chinese Herb ◽  
D2 Receptor ◽  
Treatment Strategies ◽  
Fixed Ratio ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Pharmacological Profile ◽  
Self Administration ◽  
D1 And D2 Receptors ◽  
Naturally Occurring

Given the problems associated with the escalation in methamphetamine (METH) use, the identification of more effective treatment strategies is essential. l-stepholidine (l-SPD) is an alkaloid extract of the Chinese herb Stephania intermedia with dopamine D1 receptor partial agonistic and D2 receptor antagonistic dual actions. The unique pharmacological profile of l-SPD suggests that l-SPD may be effective for the treatment of METH addiction. The aim of this study was to characterize the effect of l-SPD on METH self-administration on a fixed-ratio 1 schedule. We found that 5 and 10 mg/kg of l-SPD attenuated METH self-administration behavior. These results demonstrate that l-SPD which possesses dual actions on dopamine D1 and D2 receptors, attenuates METH self-administration on a fixed-ratio 1 schedule.

Decreased Oral Self-Administration of Alcohol In ??-Opioid Receptor Knock-Out Mice

2005 ◽  
Vol 29 (5) ◽  
pp. 730-738 ◽  
Author(s):  
Krisztina M. Kovacs ◽  
Istvan Szakall ◽  
Danielle O???Brien ◽  
Ray Wang ◽  
K Yaragudri Vinod ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Self Administration ◽  
Knock Out ◽  
Knock Out Mice
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