scholarly journals Enhanced NMDA Receptor-Mediated Synaptic Transmission, Enhanced Long-Term Potentiation, and Impaired Learning and Memory in Mice Lacking IRSp53

2009 ◽  
Vol 29 (5) ◽  
pp. 1586-1595 ◽  
Author(s):  
M.-H. Kim ◽  
J. Choi ◽  
J. Yang ◽  
W. Chung ◽  
J.-H. Kim ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Synaptic Transmission ◽  
Learning And Memory ◽  
Long Term Potentiation ◽  
Term Potentiation

scholarly journals Synaptic memory requires CaMKII

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Wucheng Tao ◽  
Joel Lee ◽  
Xiumin Chen ◽  
Javier Díaz-Alonso ◽  
Jing Zhou ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Learning And Memory ◽  
Long Term Potentiation ◽  
Cellular Model ◽  
Term Potentiation

Long-term potentiation (LTP) is arguably the most compelling cellular model for learning and memory. While the mechanisms underlying the induction of LTP ('learning') are well understood, the maintenance of LTP ('memory') has remained contentious over the last 20 years. Here, we find that CaMKII contributes to synaptic transmission and is required LTP maintenance. Acute inhibition of CaMKII erases LTP and transient inhibition of CaMKII enhances subsequent LTP. These findings strongly support the role of CaMKII as a molecular storage devise.

Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus

Nature ◽  
1991 ◽  
Vol 349 (6305) ◽  
pp. 156-158 ◽  
Author(s):  
Zafar I. Bashir ◽  
Simon Alford ◽  
Stephen N. Davies ◽  
Andrew D. Randall ◽  
Graham L. Collingridge
Keyword(s):  
Nmda Receptor ◽  
Synaptic Transmission ◽  
Long Term Potentiation ◽  
Term Potentiation

Arousing the LTP and learning debate

1997 ◽  
Vol 20 (4) ◽  
pp. 622-623 ◽  
Author(s):  
Stephen Maren
Keyword(s):  
Learning And Memory ◽  
Long Term Potentiation ◽  
Term Potentiation ◽  
Arousal Mechanism

Shors & Matzel provide compelling arguments against a role for hippocampal long-term potentiation (LTP) in mammalian learning and memory. As an alternative, they suggest that LTP is an arousal mechanism. I will argue that this view is not a satisfactory alternative to current conceptions of LTP function.

Sign in / Sign up

Export Citation Format

Share Document