scholarly journals Persistence of Experience-Induced Homeostatic Synaptic Plasticity through Adulthood in Superficial Layers of Mouse Visual Cortex

2007 ◽  
Vol 27 (25) ◽  
pp. 6692-6700 ◽  
Author(s):  
A. Goel ◽  
H.-K. Lee
Keyword(s):  
Synaptic Plasticity ◽  
Visual Cortex ◽  
Homeostatic Synaptic Plasticity ◽  
Mouse Visual Cortex

scholarly journals HDAC2 expression in parvalbumin interneurons regulates synaptic plasticity in the mouse visual cortex

2015 ◽  
Vol 1 ◽  
pp. 34-40 ◽  
Author(s):  
Alexi Nott ◽  
Sukhee Cho ◽  
Jinsoo Seo ◽  
Li-Huei Tsai
Keyword(s):  
Synaptic Plasticity ◽  
Visual Cortex ◽  
Parvalbumin Interneurons ◽  
Mouse Visual Cortex

scholarly journals BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual Cortex

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Emily Petrus ◽  
Hey-Kyoung Lee
Keyword(s):  
Synaptic Plasticity ◽  
Visual Cortex ◽  
Synaptic Transmission ◽  
Sensory Experience ◽  
Synaptic Function ◽  
Excitatory Synaptic Transmission ◽  
Early Gene ◽  
Dependent Manner ◽  
Homeostatic Synaptic Plasticity ◽  
Activity Dependent

Alzheimer’s disease (AD) is the most common form of age-related dementia, which is thought to result from overproduction and/or reduced clearance of amyloid-beta (Aβ) peptides. Studies over the past few decades suggest that Aβis produced in an activity-dependent manner and has physiological relevance to normal brain functions. Similarly, physiological functions forβ- andγ-secretases, the two key enzymes that produce Aβby sequentially processing the amyloid precursor protein (APP), have been discovered over recent years. In particular, activity-dependent production of Aβhas been suggested to play a role in homeostatic regulation of excitatory synaptic function. There is accumulating evidence that activity-dependent immediate early gene Arc is an activity “sensor,” which acts upstream of Aβproduction and triggers AMPA receptor endocytosis to homeostatically downregulate the strength of excitatory synaptic transmission. We previously reported that Arc is critical for sensory experience-dependent homeostatic reduction of excitatory synaptic transmission in the superficial layers of visual cortex. Here we demonstrate that mice lacking the major neuronalβ-secretase, BACE1, exhibit a similar phenotype: stronger basal excitatory synaptic transmission and failure to adapt to changes in visual experience. Our results indicate that BACE1 plays an essential role in sensory experience-dependent homeostatic synaptic plasticity in the neocortex.

scholarly journals Disruption of NMDAR Function Prevents Normal Experience-Dependent Homeostatic Synaptic Plasticity in Mouse Primary Visual Cortex

2019 ◽  
Vol 39 (39) ◽  
pp. 7664-7673 ◽  
Author(s):  
Gabriela Rodriguez ◽  
Lukas Mesik ◽  
Ming Gao ◽  
Samuel Parkins ◽  
Rinki Saha ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Homeostatic Synaptic Plasticity

scholarly journals Brief Novel Visual Experience Fundamentally Changes Synaptic Plasticity in the Mouse Visual Cortex

2017 ◽  
Vol 37 (39) ◽  
pp. 9353-9360 ◽  
Author(s):  
Shuo Li ◽  
Laijian Wang ◽  
Xiaoxiu Tie ◽  
Kazuhiro Sohya ◽  
Xian Lin ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Visual Cortex ◽  
Visual Experience ◽  
Mouse Visual Cortex

scholarly journals Developmental alcohol exposure impairs synaptic plasticity without overtly altering microglial function in mouse visual cortex

2018 ◽  
Vol 67 ◽  
pp. 257-278 ◽  
Author(s):  
Elissa L. Wong ◽  
Nina M. Lutz ◽  
Victoria A. Hogan ◽  
Cassandra E. Lamantia ◽  
Helene R. McMurray ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Visual Cortex ◽  
Alcohol Exposure ◽  
Mouse Visual Cortex

scholarly journals Author Correction: Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex

2019 ◽  
Vol 23 (1) ◽  
pp. 152-152
Author(s):  
Rianne D. Stowell ◽  
Grayson O. Sipe ◽  
Ryan P. Dawes ◽  
Hanna N. Batchelor ◽  
Katheryn A. Lordy ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Visual Cortex ◽  
Mouse Visual Cortex

scholarly journals Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex

2019 ◽  
Vol 22 (11) ◽  
pp. 1782-1792 ◽  
Author(s):  
Rianne D. Stowell ◽  
Grayson O. Sipe ◽  
Ryan P. Dawes ◽  
Hanna N. Batchelor ◽  
Katheryn A. Lordy ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Visual Cortex ◽  
Mouse Visual Cortex
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