A Case of Hereditary Spherocytosis Initially Manifested as an Aplastic Crisis Caused by Parvovirus B19 Infection

Abstract Hereditary spherocytosis is an inherited hemolytic anemia due to red cell membrane defects, characterised by chronic hemolysis with different severity degrees, splenomegaly and microspherocytosis on the peripheral blood film. Among the possible complications in these patients are aplastic crisis and extramedullary hematopoiesis. In this article we present the case of a 42 years old man with hereditary spherocytosis diagnosed during childhood (average haemoglobin (Hb) value of 11-12 g/dl), which presented with worsening anemia, fever, chills, bone and muscle pain. The evolution was with accentuation of anemia (Hb 4.2 g/dl), decease of reticulocyte number (Ret 0,8%) and bilirubin (indirect bilirubin 2.7 g/dl). ParvovirusB19 DNA was 100.000.000 copies/ml. A computer tomography (CT)scan was performed and showed extramedullary hematopoiesis areas situated paravertebraly in the inferior thorax and hepatosplenomegaly. The infectious episode was self-limited and improved with substitution treatment.

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Aplastic Crisis Induced by Human Parvovirus B19 Infection as an Initial Presentation of Hereditary Spherocytosis

The Indian Journal of Pediatrics ◽

10.1007/s12098-010-0204-0 ◽

2010 ◽

Vol 77 (10) ◽

pp. 1191-1192

Author(s):

Betul Tavil ◽

Semanur Ozdel ◽

Serdar Ozkasap ◽

Nese Yarali ◽

Bahattin Tunc

Keyword(s):

Hereditary Spherocytosis ◽

Parvovirus B19 ◽

Initial Presentation ◽

Human Parvovirus B19 ◽

Aplastic Crisis ◽

Parvovirus B19 Infection

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Autoimmune Hemolytic Anemia after Aplastic Crisis due to Parvovirus B19 Infection in a Patient with Hereditary Spherocytosis

Laboratory Medicine Online ◽

10.3343/lmo.2012.2.3.166 ◽

2012 ◽

Vol 2 (3) ◽

pp. 166 ◽

Cited By ~ 1

Author(s):

Sae Am Song ◽

Min-Young Lee ◽

Si Hyun Kim ◽

Ja Young Lee ◽

Seung Hwan Oh ◽

...

Keyword(s):

Hemolytic Anemia ◽

Autoimmune Hemolytic Anemia ◽

Hereditary Spherocytosis ◽

Parvovirus B19 ◽

Aplastic Crisis ◽

Parvovirus B19 Infection

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Aplastic crisis due to human parvovirus B19 infection in hereditary hemolytic anaemia

Revista do Instituto de Medicina Tropical de São Paulo ◽

10.1590/s0036-46651992000500017 ◽

1992 ◽

Vol 34 (5) ◽

pp. 479-482 ◽

Cited By ~ 12

Author(s):

R. C. N. Cubel ◽

M. C. Valadão ◽

W. V. Pereira ◽

M. C. Magalhães ◽

J. P. Nascimento

Keyword(s):

Sickle Cell ◽

Rio De Janeiro ◽

Sickle Cell Anaemia ◽

Hereditary Spherocytosis ◽

Parvovirus B19 ◽

Human Parvovirus B19 ◽

Aplastic Crisis ◽

Parvovirus B19 Infection ◽

Transient Aplastic Crisis ◽

Santa Maria

Specific anti-B19 IgM was demonstrated in sera from three children showing transient aplastic crisis. A two years-old boy living in Rio de Janeiro suffering from sickle-cell anaemia showed the crisis during August, 1990. Two siblings living in Santa Maria, RS, developed aplastic crisis during May, 1991, when they were also diagnosed for hereditary spherocytosis. For a third child from this same family, who first developed aplastic crisis no IgM anti-B19 was detected in her sera.

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