scholarly journals CD154 for the dragon: a promising development for pancreatic islet transplantation and cure for type 1 diabetes mellitus

2000 ◽  
pp. 111-113 ◽  
Author(s):  
MA Hussain
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Pancreatic Islet Transplantation ◽  
Promising Development

scholarly journals Gene Therapy to Improve Pancreatic Islet Transplantation for Type 1 Diabetes Mellitus

2010 ◽  
Vol 6 (5) ◽  
pp. 274-284 ◽  
Author(s):  
Amy Hughes ◽  
Claire Jessup ◽  
Chris Drogemuller ◽  
Daisy Mohanasundaram ◽  
Clyde Milner ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gene Therapy ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Pancreatic Islet Transplantation

First Brazilian pancreatic islet transplantation in a patient with type 1 diabetes mellitus

2004 ◽  
Vol 36 (4) ◽  
pp. 1117-1118 ◽  
Author(s):  
F.G Eliaschewitz ◽  
C.A.M Aita ◽  
T Genzini ◽  
I.L Noronha ◽  
F.H Lojudice ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Pancreatic Islet Transplantation

scholarly journals Carbon Monoxide in Pancreatic Islet Transplantation: A New Therapeutic Alternative to Patients With Severe Type 1 Diabetes Mellitus

2021 ◽  
Vol 12 ◽  
Author(s):  
George J. Dugbartey
Keyword(s):  
Diabetes Mellitus ◽  
Carbon Monoxide ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Molecular Mechanisms ◽  
Pancreatic Islet Transplantation

Pancreatic islet transplantation is a minimally invasive procedure to replace β-cells in a subset of patients with autoimmune type 1 diabetic mellitus, who are extremely sensitive to insulin and lack counter-regulatory measures, and thereby increasing their risk of neuroglycopenia and hypoglycemia unawareness. Thus, pancreatic islet transplantation restores normoglycemia and insulin independence, and prevents long-term surgical complications associated with whole-organ pancreas transplantation. Nonetheless, relative inefficiency of islet isolation and storage process as well as progressive loss of islet function after transplantation due to unvoidable islet inflammation and apoptosis, hinder a successful islet transplantation. Carbon monoxide (CO), a gas which was once feared for its toxicity and death at high concentrations, has recently emerged as a medical gas that seems to overcome the challenges in islet transplantation. This minireview discusses recent findings about CO in preclinical pancreatic islet transplantation and the underlying molecular mechanisms that ensure islet protection during isolation, islet culture, transplantation and post-transplant periods in type 1 diabetic transplant recipients. In addition, the review also discusses clinical translation of these promising experimental findings that serve to lay the foundation for CO in islet transplantation to replace the role of insulin therapy, and thus acting as a cure for type 1 diabetes mellitus and preventing long-term diabetic complications.

Clinical islet transplantation in type 1 diabetes mellitus: results of Australia's first trial

2006 ◽  
Vol 184 (5) ◽  
pp. 221-225 ◽  
Author(s):  
Philip J O’Connell ◽  
Wayne J Hawthorne ◽  
Brian J Nankivell ◽  
Anita T Patel ◽  
Stacey N Walters ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Islet Transplantation ◽  
Clinical Islet Transplantation

Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen

2000 ◽  
Vol 343 (4) ◽  
pp. 230-238 ◽  
Author(s):  
A.M. James Shapiro ◽  
Jonathan R.T. Lakey ◽  
Edmond A. Ryan ◽  
Gregory S. Korbutt ◽  
Ellen Toth ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Islet Transplantation ◽  
Immunosuppressive Regimen

scholarly journals Reduction in Carotid Intima-Media Thickness After Pancreatic Islet Transplantation in Patients With Type 1 Diabetes

Diabetes Care ◽  
2012 ◽  
Vol 36 (2) ◽  
pp. 450-456 ◽  
Author(s):  
K. K. Danielson ◽  
B. Hatipoglu ◽  
K. Kinzer ◽  
B. Kaplan ◽  
J. Martellotto ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Pancreatic Islet Transplantation ◽  
Media Thickness
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