Hyperinsulinaemia due to inhibition of 5[alpha]-reductases is ameliorated by liver-selective glucocorticoid receptor antagonism in diet-induced obesity

2015 ◽  
Author(s):  
Tracy C S Mak ◽  
Dawn E W Livingstone ◽  
Brian R Walker ◽  
Ruth Andrew
Keyword(s):  
Glucocorticoid Receptor ◽  
Receptor Antagonism ◽  
Diet Induced Obesity

scholarly journals Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation

2016 ◽  
Vol 173 (11) ◽  
pp. 1793-1804 ◽  
Author(s):  
José K van den Heuvel ◽  
Mariëtte R Boon ◽  
Ingmar van Hengel ◽  
Emma Peschier-van der Put ◽  
Lianne van Beek ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Receptor Modulator ◽  
Diet Induced Obesity

Liver-selective glucocorticoid receptor antagonism decreases glucose production and increases glucose disposal, ameliorating insulin resistance

Metabolism ◽  
2007 ◽  
Vol 56 (3) ◽  
pp. 380-387 ◽  
Author(s):  
Bradley Zinker ◽  
Amanda Mika ◽  
Phong Nguyen ◽  
Denise Wilcox ◽  
Lars Öhman ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Glucocorticoid Receptor ◽  
Glucose Production ◽  
Glucose Disposal ◽  
Receptor Antagonism

scholarly journals Glucocorticoid Receptor Antagonism as a Novel Therapy for Triple-Negative Breast Cancer

2013 ◽  
Vol 19 (22) ◽  
pp. 6163-6172 ◽  
Author(s):  
Maxwell N. Skor ◽  
Erin L. Wonder ◽  
Masha Kocherginsky ◽  
Anju Goyal ◽  
Ben A. Hall ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Glucocorticoid Receptor ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Novel Therapy ◽  
Receptor Antagonism

Glucocorticoid Receptor Antagonism of AP-1 Activity by Inhibition of MAPK Family

2002 ◽  
pp. 131-152 ◽  
Author(s):  
C. Caelles ◽  
A. Bruna ◽  
M. Morales ◽  
J. M. González-Sancho ◽  
M. V. González ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Receptor Antagonism

scholarly journals Glucocorticoid receptor antagonism overcomes resistance to BRAF inhibition in BRAFV600E-mutated metastatic melanoma

2020 ◽  
Vol 138 ◽  
pp. S41
Author(s):  
E. Obrador ◽  
J.M. Estrela ◽  
R. Salvador ◽  
P. Marchio ◽  
S.L. Valles ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Metastatic Melanoma ◽  
Receptor Antagonism ◽  
Braf Inhibition
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