Altered effective connectivity in migraine patients during emotional stimuli: a multi-frequency magnetoencephalography study

Background Migraine is a common and disabling primary headache, which is associated with a wide range of psychiatric comorbidities. However, the mechanisms of emotion processing in migraine are not fully understood yet. The present study aimed to investigate the neural network during neutral, positive, and negative emotional stimuli in the migraine patients. Methods A total of 24 migraine patients and 24 age- and sex-matching healthy controls were enrolled in this study. Neuromagnetic brain activity was recorded using a whole-head magnetoencephalography (MEG) system upon exposure to human facial expression stimuli. MEG data were analyzed in multi-frequency ranges from 1 to 100 Hz. Results The migraine patients exhibited a significant enhancement in the effective connectivity from the prefrontal lobe to the temporal cortex during the negative emotional stimuli in the gamma frequency (30–90 Hz). Graph theory analysis revealed that the migraine patients had an increased degree and clustering coefficient of connectivity in the delta frequency range (1–4 Hz) upon exposure to positive emotional stimuli and an increased degree of connectivity in the delta frequency range (1–4 Hz) upon exposure to negative emotional stimuli. Clinical correlation analysis showed that the history, attack frequency, duration, and neuropsychological scales of the migraine patients had a negative correlation with the network parameters in certain frequency ranges. Conclusions The results suggested that the individuals with migraine showed deviant effective connectivity in viewing the human facial expressions in multi-frequencies. The prefrontal-temporal pathway might be related to the altered negative emotional modulation in migraine. These findings suggested that migraine might be characterized by more universal altered cerebral processing of negative stimuli. Since the significant result in this study was frequency-specific, more independent replicative studies are needed to confirm these results, and to elucidate the neurocircuitry underlying the association between migraine and emotional conditions.

Presenting KAPODI – The Searchable Database of Emotional Stimuli Sets

Emotional stimuli such as images, words, or video clips are often used in studies researching emotion. New sets are continuously being published, creating an immense number of available sets and complicating the task for researchers who are looking for suitable stimuli. This paper presents the KAPODI-database of emotional stimuli sets that are freely available or available upon request. Over 45 aspects including over 25 key set characteristics have been extracted and listed for each set. The database facilitates finding of and comparison between individual sets. It currently contains sets published between 1963 and 2020. A searchable online version ( https://airtable.com/shrnVoUZrwu6riP9b ) allows users to select specific set characteristics and to find matching sets accordingly, as well as to add new published sets.

The Temporal Aspect of Bodily Experiences of Emotions: Where do You Feel The First Sensation?

Recently, body maps have increasingly been used to identify patterns in respect of the location of the physical sensations elicited by emotions. However, in addition to understanding how emotions are topographically manifest in the body, it is important to add a temporal aspect to deepen the interoceptive study of emotions. Therefore, the present study sought to explore the first perceived sensation. The study sample comprised a group of mindfulness practitioners (n=34) and a group of non-practitioners (n=64) to analyze if there was any difference in their perceptions of emotion. Participants were instructed to evoke five basic emotions (fear, disgust, anger, sadness, joy), and as soon as they became aware of where they felt the emotions start to emerge, were instructed to interrupt the observation and to indicate the region in a diagram of a human figure. Overall, the groups did not differ in the body regions identified for each emotion. Cochran's Q-test showed that the main regions mentioned were the head and the chest. In the case of disgust, the neck, rather than the chest, along with the lower part of the head were the most cited. The most cited regions corresponded to those identified in other studies of body topography as perceived with the greatest increase in activity in response to emotional stimuli. Regarding interoceptive awareness, the independent t-test verified that the mindfulness group scored significantly higher in all subscales of the Brazilian Portuguese version of the 37-item Multidimensional Assessment of Interoceptive Awareness questionnaire compared to the non-mindfulness group.

The Temporal Aspect of Bodily Experiences of Emotions: Where do You Feel The First Sensation?

Recently, body maps have increasingly been used to identify patterns in respect of the location of the physical sensations elicited by emotions. However, in addition to understanding how emotions are topographically manifest in the body, it is important to add a temporal aspect to deepen the interoceptive study of emotions. Therefore, the present study sought to explore the first perceived sensation. The study sample comprised a group of mindfulness practitioners (n=34) and a group of non-practitioners (n=64) to analyze if there was any difference in their perceptions of emotion. Participants were instructed to evoke five basic emotions (fear, disgust, anger, sadness, joy), and as soon as they became aware of where they felt the emotions start to emerge, were instructed to interrupt the observation and to indicate the region in a diagram of a human figure. Overall, the groups did not differ in the body regions identified for each emotion. Cochran's Q-test showed that the main regions mentioned were the head and the chest. In the case of disgust, the neck, rather than the chest, along with the lower part of the head were the most cited. The most cited regions corresponded to those identified in other studies of body topography as perceived with the greatest increase in activity in response to emotional stimuli. Regarding interoceptive awareness, the independent t-test verified that the mindfulness group scored significantly higher in all subscales of the Brazilian Portuguese version of the 37-item Multidimensional Assessment of Interoceptive Awareness questionnaire compared to the non-mindfulness group.

Affective disposition and cognitive processing in dysphoria: a time-frequency EEG study

To date, affective disposition and cognitive processing of emotional stimuli in individuals with depressive symptoms have not been fully explored within the same framework. Time-frequency analysis of electroencephalographic activity allows to disentangle the brain's parallel processing of information. The present study employed a time-frequency approach to simultaneously examine affective disposition and cognitive processing during the viewing of emotional stimuli in dysphoria. Time-frequency event-related changes were examined during the viewing of pleasant, neutral and unpleasant pictures in 24 individuals with dysphoria and 24 controls. Affective disposition was indexed by delta and alpha power, while theta power was employed as a correlate of cognitive elaboration of the stimuli. Cluster-based statistics revealed a centro-parietal reduction in delta power for pleasant stimuli in individuals with dysphoria than controls. Also, dysphoria was characterized by an early fronto-central increase in theta power for unpleasant stimuli relative to neutral and pleasant. Instead, controls were characterized by a late fronto-central and occipital reduction in theta power for unpleasant stimuli relative to neutral and pleasant. The present study granted novel insights on the interrelated facets of affective elaboration in dysphoria, mainly characterized by an hypoactivation of the approach-related motivational system and a sustained facilitated cognitive processing of unpleasant stimuli.

Event-Related Potentials in Women on the Pill: Neural Correlates of Positive and Erotic Stimulus Processing in Oral Contraceptive Users

Background/Aims: Exposure toward positive emotional cues with – and without – reproductive significance plays a crucial role in daily life and regarding well-being as well as mental health. While possible adverse effects of oral contraceptive (OC) use on female mental and sexual health are widely discussed, neural processing of positive emotional stimuli has not been systematically investigated in association with OC use. Considering reported effects on mood, well-being and sexual function, and proposed associations with depression, it was hypothesized that OC users showed reduced neural reactivity toward positive and erotic emotional stimuli during early as well as later stages of emotional processing and also rated these stimuli as less pleasant and less arousing compared to naturally cycling (NC) women.Method: Sixty-two female subjects (29 NC and 33 OC) were assessed at three time points across the natural menstrual cycle and corresponding time points of the OC regimen. Early (early posterior negativity, EPN) and late (late positive potential, LPP) event-related potentials in reaction to positive, erotic and neutral stimuli were collected during an Emotional Picture Stroop Paradigm (EPSP). At each appointment, subjects provided saliva samples for analysis of gonadal steroid concentration. Valence and arousal ratings were collected at the last appointment.Results: Oral contraceptive users had significantly lower endogenous estradiol and progesterone concentrations compared to NC women. No significant group differences in either subjective stimulus evaluations or neural reactivity toward positive and erotic emotional stimuli were observed. For the OC group, LPP amplitudes in reaction to erotic vs. neutral pictures differed significantly between measurement times across the OC regimen.Discussion: In this study, no evidence regarding alterations of neural reactivity toward positive and erotic stimuli in OC users compared to NC was found. Possible confounding factors and lines for future research are elaborated and discussed.

A Review on Emotion-Enhanced Recognition Memory: Response Bias and Context Caused by Emotional Stimuli

The current study aims to present the main lines of the topic by compiling the literature on the effect of emotion on recognition memory and address some considerations for future studies by highlighting the attention-grabbing points related to emotion-memory interaction. A growing body of literature has demonstrated that emotional stimuli are better remembered than their neutral equivalents. Based on these common findings, research in the relevant literature is reviewed in detail regarding various approaches that define and explain emotion; and the effect of emotional dimensions, which are defined within the framework of different approaches, on recognition memory is mentioned. Empirical studies are also reviewed by including the findings on the response biases that emotion might cause. On the other hand, the factor affecting memory performance is not solely due to emotional stimuli' dimensions. Instead, memory performance might be positively affected by the context of emotional stimuli. Additionally, how emotional memory is studied in a controlled laboratory setting is discussed. Within this context, emotional databases developed to investigate emotion-memory interaction and databases designed for research to be carried out in Turkey are discussed. To sum up, within the scope of the current review, it is concluded that future studies on emotion and recognition memory interaction should take response bias caused by emotion, emotional context, and type of emotional stimuli into account to reach more consistent results. Keywords: Emotion, recognition memory, response bias, context, databases

Flexibility in autism during unpredictable shifts of socio-emotional stimuli: Investigation of group and sex differences

Considering the mixed nature of reports of flexibility difficulties in autism, we hypothesized that a task that more closely resembles the challenges faced in real life would help to assess these difficulties. Autistic and typically developing adults performed an online Emotional Shifting Task, involving non-explicit unpredictable shifts of complex socio-emotional stimuli, and the Task Switching Task, involving explicit predictable shifts of simple character stimuli. Switch cost (i.e. the difference in performance between Shift and Non Shift conditions) was larger in the autistic group than in the comparison group for the Emotional Shifting Task but not for the Task Switching Task. Females responded faster than males in the Emotional Shifting Task. On the Task Switching Task, typically developing males responded faster than typically developing females, whereas there was a female advantage in the autistic group. Our findings suggest that factors such as predictability, explicitness of the shift rule, stimulus type as well as sex could play a critical role in flexibility difficulties in autism. Lay abstract Flexibility difficulties in autism might be particularly common in complex situations, when shifts (i.e. the switch of attentional resources or strategy according to the situation) are unpredictable, implicit (i.e. not guided by explicit rules) and the stimuli are complex. We analyzed the data of 101 autistic and 145 non-autistic adults, without intellectual deficiency, on two flexibility tasks performed online. The first task involved unpredictable and non-explicit shifts of complex socio-emotional stimuli, whereas the second task involved predictable and explicit shifts of character stimuli. Considering the discrepancies between laboratory results and the real-life flexibility-related challenges faced by autistic individuals, we need to determine which factor could be of particular importance in flexibility difficulties. We point out that the switch cost (i.e. the difference between shift and non-shift condition) was larger for autistic than for non-autistic participants on the complex flexibility task with unpredictable and non-explicit shifts of socio-emotional stimuli, whereas this was not the case when shifts were predictable, explicit and involved less complex stimuli. We also highlight sex differences, suggesting that autistic females have better social skills than autistic males and that they also have a specific cognitive profile, which could contribute to social camouflaging. The findings of this work help us understand which factors could influence flexibility difficulties in autism and are important for designing future studies. They also add to the literature on sex differences in autism which underpin better social skills, executive function, and camouflaging in autistic females.

Effects of 15-Day Head-Down Bed Rest on Emotional Time Perception

Accurate time perception is clearly essential for the successful implementation of space missions. To elucidate the effect of microgravity on time perception, we used three emotional picture stimuli: neutral, fear, and disgust, in combination with a temporal bisection task to measure 16 male participants’ time perception in 15 days of –6° head-down bed rest, which is a reliable simulation model for most physiological effects of spaceflight. We found that: (1) participants showed temporal overestimation of the fear stimuli in the middle phase (day 8), suggesting that when participants’ behavioral simulations were consistent with the action implications of the emotional stimuli, they could still elicit an overestimation of time even if the subjective arousal of the emotional stimuli was not high. (2) Participants’ temporal sensitivity tends to get worse in the bed rest phase (days 8 and 15) and better in the post-bed rest phase, especially for neutral and fear stimuli, suggesting that multiple presentations of short-term emotional stimuli may also lead to a lack of affective effects. This reduced the pacemaker rate and affected temporal perceptual sensitivity. Also, this may be related to changes in physiological factors in participants in the bed rest state, such as reduced vagal excitability. These results provide new evidence to support the theory of embodied cognition in the context of time perception in head-down bed rest and suggest important perspectives for future perception science research in special environments such as microgravity.