Lipoatrophic Diabetes Mellitus: a rare special type!

2018 ◽  
Author(s):  
Shaimaa A Fathy ◽  
Aasem Seif ◽  
Heba Sherif ◽  
Dina Farouk
Keyword(s):  
Diabetes Mellitus ◽  
Lipoatrophic Diabetes

Lipoatrophic Diabetes Mellitus

2003 ◽  
pp. 185-214
Author(s):  
Elif Arioglu Oral ◽  
Stephanie Moran
Keyword(s):  
Diabetes Mellitus ◽  
Lipoatrophic Diabetes

Successful pregnancy outcome in association with lipoatrophic diabetes mellitus

1990 ◽  
Vol 76 (5) ◽  
pp. 978-979 ◽  
Author(s):  
Patrick M. Catalano ◽  
Eleanor L. Capeless ◽  
George M. Simmons ◽  
David C. Robbins ◽  
Edward S. Horton
Keyword(s):  
Diabetes Mellitus ◽  
Pregnancy Outcome ◽  
Successful Pregnancy ◽  
Lipoatrophic Diabetes

SUCCESSFUL PREGNANCY OUTCOME IN ASSOCIATION WITH LIPOATROPHIC DIABETES MELLITUS

1990 ◽  
Vol 76 (Supplement) ◽  
pp. 978-979
Author(s):  
Patrick M. Catalano ◽  
Eleanor L. Capeless ◽  
George M. Simmons ◽  
David C. Robbins ◽  
Edward S. Horton
Keyword(s):  
Diabetes Mellitus ◽  
Pregnancy Outcome ◽  
Successful Pregnancy ◽  
Lipoatrophic Diabetes

scholarly journals Combination of lipoatrophic diabetes mellitus with systemic scleroderma and phenylketonuria

2017 ◽  
Vol 63 (2) ◽  
pp. 130-133
Author(s):  
Galina N. Svetlova ◽  
Tamara L. Kuraeva ◽  
Dmitriy L. Alekseev ◽  
Valentina A. Peterkova
Keyword(s):  
Diabetes Mellitus ◽  
Molecular Genetic ◽  
Clinical Manifestations ◽  
Molecular Genetic Analysis ◽  
Systemic Scleroderma ◽  
Dietary Regimen ◽  
Insulin Resistant ◽  
Lipoatrophic Diabetes ◽  
Liver Functions ◽  
High Doses

We present the first report of a rare form of lipoatrophic diabetes mellitus in a child with partial autoimmune lipodystrophy combined with systemic scleroderma and phenylketonuria. We describe the features of clinical manifestations, diagnosis, and therapy. To exclude the monogenic form of lipodystrophy, we performed a molecular genetic analysis of genes ZMPSTE24, LMNA, BSCL2, PLIN1, PTRF, LMNB2, POLD1, AKT2, CIDEC, PIK3CA, PPARG, PSMB8, CAV1, PPP1R3A, and AGPAT2 that are responsible for the development of lipodystrophy and insulin resistance. No mutations were found. The presence of systemic scleroderma of autoimmune genesis enabled the diagnosis of autoimmune lipodystrophy. Treatment of insulin-resistant diabetes mellitus in lipodystrophy is a challenge: biguanide therapy is dangerous due to impairment of liver functions, and insulin therapy is not effective enough; administration of high doses is required. The presence of phenylketonuria further complicates compliance with the dietary regimen. The combination of three rare diseases ― lipoatrophic diabetes, phenylketonuria, and systemic scleroderma ― in one patient has not been found in the available literature.

SUCCESSFUL OUTCOME OF PREGNANCY IN A PATIENT WITH GENERALIZED LIPOATROPHIC DIABETES MELLITUS

2000 ◽  
Vol 6 (1) ◽  
pp. 34-36 ◽  
Author(s):  
Beverly K. Dolberg, MD ◽  
M. James Lenhard, MD, FACE
Keyword(s):  
Diabetes Mellitus ◽  
Successful Outcome ◽  
Lipoatrophic Diabetes
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