Effect of maternal thyroid function on neonatal thyroid screening results

2019 ◽  
Author(s):  
M Dolores Ollero ◽  
Juan Pablo Martinez de Esteban ◽  
J Javier Pineda ◽  
Emma Anda ◽  
Marta Toni ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Thyroid Screening ◽  
Maternal Thyroid ◽  
Neonatal Thyroid Screening

Neonatal thyroid screening results are related to gestational maternal thyroid function

2011 ◽  
Vol 75 (3) ◽  
pp. 382-387 ◽  
Author(s):  
S.M.I. Kuppens ◽  
L. Kooistra ◽  
H.A. Wijnen ◽  
H.L. Vader ◽  
T.H.M. Hasaart ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Thyroid Screening ◽  
Maternal Thyroid ◽  
Neonatal Thyroid Screening

scholarly journals CONTROVERSIES IN ENDOCRINOLOGY: On the need for universal thyroid screening in pregnant women

2014 ◽  
Vol 170 (1) ◽  
pp. R17-R30 ◽  
Author(s):  
Lluís Vila ◽  
Inés Velasco ◽  
Stella González ◽  
Francisco Morales ◽  
Emilia Sánchez ◽  
...  
Keyword(s):  
Thyroid Function ◽  
First Trimester ◽  
Specific Reference ◽  
Geographic Variations ◽  
Scientific Societies ◽  
Need For Treatment ◽  
Positive Effects ◽  
Thyroid Screening ◽  
Iodine Supplementation ◽  
Widespread Agreement

There is a well-known controversy among scientific societies regarding the recommendation to screen for thyroid dysfunction (TD) during pregnancy. Although several studies have shown an association between maternal subclinical hypothyroidism and/or hypothyroxinemia with obstetric problems and/or neurocognitive impairment in the offspring, there is only limited evidence on the possible positive effects of thyroxine (T4) treatment in such cases. Despite the scarcity of this evidence, there is a widespread agreement among clinicians on the need for treatment of clinical hypothyroidism during pregnancy and the risks that could arise due to therapeutic abstention. As maternal TD is a quite prevalent condition, easily diagnosed and for which an effective and safe treatment is available, some scientific societies have proposed to assess thyroid function during the first trimester of pregnancy and ideally before week 10 of gestational age. Given the physiologic changes of thyroid function during pregnancy, hormone assessment should be performed using trimester-specific reference values ideally based on locally generated data as geographic variations have been detected. Screening of TD should be based on an initial determination of TSH performed early during the first trimester and only if abnormal should it be followed by either a free or total T4measurement. Furthermore, adequate iodine supplementation during pregnancy is critical and if feasible it should be initiated before the woman attempts to conceive.

Careful Assessment of Maternal Thyroid Function Can Prevent Cases of Fetal Goitrous Hypothyroidism

2013 ◽  
Vol 34 (1) ◽  
pp. 66-68 ◽  
Author(s):  
Sofie Bliddal ◽  
Åse Krogh Rasmussen ◽  
Karin Sundberg ◽  
Ulla Feldt-Rasmussen
Keyword(s):  
Thyroid Function ◽  
Maternal Thyroid ◽  
Careful Assessment

scholarly journals A Novel Nomogram for Predicting the Risk of Premature Delivery Based on the Thyroid Function in Pregnant Women

2022 ◽  
Vol 12 ◽  
Author(s):  
Yu Meng ◽  
Jing Lin ◽  
Jianxia Fan
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Preterm Delivery ◽  
Thyroid Function ◽  
Premature Delivery ◽  
Multivariable Logistic Regression Analysis ◽  
Decision Curve Analysis ◽  
Cutoff Values ◽  
Lemeshow Test ◽  
Maternal Thyroid

BackgroundMaternal thyroid dysfunction and autoantibodies were associated with preterm delivery. However, recommendations for cutoff values of thyroperoxidase antibody (TPOAb) positivity and thyroid-stimulating homone (TSH) associated with premature delivery are lacking.ObjectiveTo identify the pregnancy-specific cutoff values for TPOAb positivity and TSH associated with preterm delivery. To develop a nomogram for the risk prediction of premature delivery based on maternal thyroid function in singleton pregnant women without pre-pregnancy complications.MethodsThis study included data from the International Peace Maternity and Child Care Health Hospital (IPMCH) in Shanghai, China, between January 2013 and December 2016. Added data between September 2019 and November 2019 as the test cohort. Youden’s index calculated the pregnancy-specific cutoff values for TPOAb positivity and TSH concentration. Univariate and multivariable logistic regression analysis were used to screen the risk factors of premature delivery. The nomogram was developed according to the regression coefficient of relevant variables. Discrimination and calibration of the model were assessed using the C-index, Hosmer-Lemeshow test, calibration curve and decision curve analysis.Results45,467 pregnant women were divided into the training and validation cohorts according to the ratio of 7: 3. The testing cohort included 727 participants. The pregnancy-specific cutoff values associated with the risk of premature delivery during the first trimester were 5.14 IU/mL for TPOAb positivity and 1.33 mU/L for TSH concentration. Multivariable logistic regression analysis showed that maternal age, history of premature delivery, elevated TSH concentration and TPOAb positivity in the early pregnancy, preeclampsia and gestational diabetes mellitus were risk factors of premature delivery. The C-index was 0.62 of the nomogram. Hosmer-Lemeshow test showed that the Chi-square value was 2.64 (P = 0.955 > 0.05). Decision curve analysis showed a positive net benefit. The calibration curves of three cohorts were shown to be in good agreement.ConclusionsWe identified the pregnancy-specific cutoff values for TPOAb positivity and TSH concentration associated with preterm delivery in singleton pregnant women without pre-pregnancy complications. We developed a nomogram to predict the occurrence of premature delivery based on thyroid function and other risk factors as a clinical decision-making tool.

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