Mechanisms for Cardiovascular Complications of Diabetes - Implications for Personalized Therapy

2019 ◽  
Author(s):  
E Dale Abel
Keyword(s):  
Cardiovascular Complications ◽  
Personalized Therapy ◽  
Complications Of Diabetes

Precision Medicine in Patients with Differential Diabetic Phenotypes: Novel Opportunities from Network Medicine

2021 ◽  
Vol 18 ◽  
Author(s):  
Claudio Napoli ◽  
Giuditta Benincasa ◽  
Samer Ellahham
Keyword(s):  
Precision Medicine ◽  
Protein Interactions ◽  
Randomized Clinical Trials ◽  
Growth Factor Receptor ◽  
Cardiovascular Complications ◽  
Personalized Therapy ◽  
Network Medicine ◽  
Prediabetic State ◽  
Relevant Role ◽  
Approved Drugs

Introduction: Diabetes mellitus (DM) comprises differential clinical phenotypes ranging from rare monogenic to common polygenic forms, such as type 1 (T1DM), type 2 (T2DM), and gestational diabetes, which are associated with cardiovascular complications. Also, the high-risk prediabetic state is rising worldwide, suggesting the urgent need for early personalized strategies to prevent and treat a hyperglycemic state. Objective: We aim to discuss the advantages and challenges of Network Medicine approaches in clarifying disease-specific molecular pathways, which may open novel ways for repurposing approved drugs to reach diabetes precision medicine and personalized therapy. Conclusion: The interactome [or protein-protein interactions (PPIs)] is a useful tool to identify subtle molecular differences between precise diabetic phenotypes and predict putative novel drugs. Despite being previously unappreciated as T2DM determinants, the growth factor receptor-bound protein 14 (GRB14), calmodulin 2 (CALM2), and protein kinase C-alpha (PRKCA) might have a relevant role in disease pathogenesis. Besides, in silico platforms have suggested that diflunisal, nabumetone, niflumic acid, and valdecoxib may be suitable for the treatment of T1DM; phenoxybenzamine and idazoxan for the treatment of T2DM by improving insulin secretion; and hydroxychloroquine reduce the risk of coronary heart disease (CHD) by counteracting inflammation. Network medicine has the potential to improve precision medicine in diabetes care and enhance personalized therapy. However, only randomized clinical trials will confirm the clinical utility of network-oriented biomarkers and drugs in the management of DM.

scholarly journals Potential Role of Metal Chelation to Prevent the Cardiovascular Complications of Diabetes

2019 ◽  
Vol 104 (7) ◽  
pp. 2931-2941
Author(s):  
Rossana Calderon Moreno ◽  
Ana Navas-Acien ◽  
Esteban Escolar ◽  
David M Nathan ◽  
Jonathan Newman ◽  
...  
Keyword(s):  
Potential Role ◽  
Cardiovascular Complications ◽  
Metal Chelation ◽  
Complications Of Diabetes

Postprandial hyperglycaemia and cardiovascular complications of diabetes: An update

2006 ◽  
Vol 16 (7) ◽  
pp. 453-456 ◽  
Author(s):  
Antonio Ceriello ◽  
Jamie Davidson ◽  
Markolf Hanefeld ◽  
Lawrence Leiter ◽  
Louis Monnier ◽  
...  
Keyword(s):  
Cardiovascular Complications ◽  
Postprandial Hyperglycaemia ◽  
Complications Of Diabetes
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