The effect of ramadan fasting on thyroid function tests: A study of patients on thyroxine replacement therapy

Abstract. Eleven patients with treated hypothyroidism were investigated to examine the effects of time on their thyroid function tests. Each patient was clinically and biochemically euthyroid on once daily thyroxine replacement therapy, taken in the morning. TSH followed a diurnal rhythm with a peak level at 23.30 h and a trough level at 14.30 h. Four subjects had TSH trough levels within the normal range, but with peak levels outside this range. FT4 and FT3 levels fell from their highest levels some three hours after ingestion to the lowest levels just prior to the next dose. This study shows that there are significant time-related variabilities in TSH and thyroid hormone levels in treated hypothyroid patients. This should be taken into account when interpreting results of their thyroid function tests.

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SYSTEM OF REPRODUCTION IN HYPOTHYREOSIS

V F Snegirev Archives of Obstetrics and Gynecology ◽

10.18821/2313-8726-2017-4-2-77-83 ◽

2017 ◽

Vol 4 (2) ◽

pp. 77-83

Author(s):

M. M Esina

Keyword(s):

Menstrual Cycle ◽

Thyroid Gland ◽

Replacement Therapy ◽

Thyroid Function ◽

Reproductive System ◽

Female Patients ◽

Infertile Couples ◽

Thyroxine Replacement ◽

Thyroxine Replacement Therapy

Hypothyreosis is one of the most common endocrine pathologies closely related with the reproductive system. In female patients with hypofunction of the thyroid gland, various disorders occur in the reproductive system: menstrual cycle deteriorations, miscarriage, infertility. Therefore, the study of thyroid function should be carried out as a screening in women planning pregnancy, as well as in infertile couples in the treatment of the infertility. When hypothyreosis is detected, L-thyroxine replacement therapy is necessary.

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Effect of oral intake of thyroxine on results of thyroid function tests in patients receiving thyroid replacement therapy

The Medical Journal of Australia ◽

10.5694/j.1326-5377.1983.tb122530.x ◽

1983 ◽

Vol 2 (8) ◽

pp. 374-376 ◽

Cited By ~ 4

Author(s):

David R. Deam ◽

David G. Campbell ◽

Sujiva Ratnaike

Keyword(s):

Replacement Therapy ◽

Thyroid Function ◽

Oral Intake ◽

Thyroid Function Tests ◽

Function Tests

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Thyroid Stimulating Hormone Measurement by an Ultrasensitive Assay during Thyroxine Replacement: Comparison with other Tests of Thyroid Function

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1177/000456328702400611 ◽

1987 ◽

Vol 24 (6) ◽

pp. 614-619 ◽

Cited By ~ 4

Author(s):

T Wheatley ◽

P M S Clark ◽

J D A Clark ◽

P R Raggatt ◽

O M Edwards

Keyword(s):

Replacement Therapy ◽

Thyroid Function ◽

Thyroid Stimulating Hormone ◽

Biochemical Tests ◽

Basal Serum ◽

Total Thyroxine ◽

Thyroxine Replacement ◽

Thyroxine Replacement Therapy ◽

Serum Tsh ◽

Stimulating Hormone

Serum thyroid stimulating hormone (TSH) was measured using a highly sensitive enzyme-amplified immunoassay in 37 clinically euthyroid patients receiving thyroxine replacement therapy and compared with other biochemical tests of thyroid function. A highly significant correlation ( P<0·001) was found between the basal serum TSH and the increase in serum TSH concentration 20 min after the administration of thyrotropin releasing hormone (TRH). The basal serum TSH was negatively correlated with the serum total thyroxine ( P=0·05). When patients results were classified as abnormal or normal many discrepancies were noted between the various thyroid tests. A suppressed serum TSH was found in 65% of patients with a normal serum total thyroxine. However, in patients on thyroxine replacement therapy a basal TSH measured by enzyme-amplified immunoassay provides the same information as a TRH test.

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