scholarly journals Signatures of Demographic History and Natural Selection in the Human Major Histocompatibility Complex Loci

Genetics ◽  
2006 ◽  
Vol 173 (4) ◽  
pp. 2121-2142 ◽  
Author(s):  
Diogo Meyer ◽  
Richard M. Single ◽  
Steven J. Mack ◽  
Henry A. Erlich ◽  
Glenys Thomson
Keyword(s):  
Major Histocompatibility Complex ◽  
Natural Selection ◽  
Demographic History ◽  
Major Histocompatibility ◽  
Human Major Histocompatibility Complex ◽  
Histocompatibility Complex

scholarly journals MHC*IMP – Imputation of Alleles for Genes in the Major Histocompatibility Complex

2020 ◽  
Author(s):  
David McG. Squire ◽  
Allan Motyer ◽  
Richard Ahn ◽  
Joanne Nititham ◽  
Zhi-Ming Huang ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Prediction Accuracy ◽  
Cross Validation ◽  
Whole Genome Sequencing Data ◽  
Major Histocompatibility ◽  
Sequencing Data ◽  
Imputation Model ◽  
Human Major Histocompatibility Complex ◽  
Histocompatibility Complex ◽  
Snp Data

AbstractWe report the development of MHC*IMP, a method for imputing non-classical HLA and other genes in the human Major Histocompatibility Complex (MHC). We created a reference panel for 25 genes in the MHC using allele calls from Whole Genome Sequencing data, combined with SNP data for the same individuals. We used this to construct an allele imputation model, MHC*IMP, for each gene. Cross-validation showed that MHC*IMP performs very well, with allele prediction accuracy 93% or greater for all but two of the genes, and greater than 95% for all but four.

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