A swine model of acute thrombocytopenia with prolonged bleeding time produced by busulfan

SummaryA prolonged bleeding time can be due to a vascular, plasmatic, or thrombocytic cause. On the basis of investigations in 8 patients with a prolonged bleeding time, these different forms are discussed.There appeared to be at least two plasmatic factors one of which is the bleeding factor of Nilsson. The demonstration of a thrombocytic cause is sometimes only possible with transfusions of normal platelet suspensions. A patient is described with a prolonged bleeding time due to an acquired thrombo-pathia, resulting from excessive haemorrhages and exchange transfusions.

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Congenital Vascular Defect Associated with Platelet Abnormality and Antihemophilic Factor Deficiency

Blood ◽

10.1182/blood.v15.6.807.807 ◽

1960 ◽

Vol 15 (6) ◽

pp. 807-829 ◽

Cited By ~ 15

Author(s):

GIOVANNI RACCUGLIA ◽

JAMES V. NEEL ◽

Ruth T. Davidson ◽

Mary Jane Ussery

Keyword(s):

Bleeding Time ◽

A Priori ◽

Dominant Gene ◽

Hemorrhagic Diathesis ◽

Prolonged Bleeding ◽

Prolonged Bleeding Time ◽

Factor Deficiency ◽

Hemorrhagic Tendency ◽

Vascular Defect ◽

Antihemophilic Factor

Abstract 1. A kindred of 311 individuals, many members of which are affected by a hemorrhagic diathesis, has been described. 2. The variability in the manifestations of this diathesis is extreme. In its fullest expression the disease is characterized by a prolonged bleeding time with evidence of a morphologic defect in the platelets, and a deficiency in antihemophilic globulin. Some possibly affected individuals exhibit only a prolonged bleeding time, while, on the other hand, the clinically most severely affected individual, with AHF levels on several occasions of 5 to 10 per cent, has not been observed by us to have a prolonged bleeding time, although his platelets are morphologically abnormal. 3. Genetic analysis suggests that the hemorrhagic tendency is determined by a single dominant gene of variable penetrance and expressivity. 4. No satisfactory explanation can be developed on the basis of these studies for the association between platelet abnormality and AHF deficiency. More specifically, it is impossible to conclude whether the platelet defect is precursor to the AHF deficiency, or whether—as on a priori grounds seems less likely—this is an example of true genetic pleiotropy. 5. The terminologic chaos which afflicts the literature on hemorrhagic diatheses characterized by a prolonged bleeding time is discussed in the light of the findings in this one large kindred, and suggestions are advanced for minimizing confusion based on terminology alone.

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Is a Prolonged Bleeding Time Associated with an Increased Risk of Hemorrhage after Liver Biopsy?

Thrombosis and Haemostasis ◽

10.1055/s-0037-1614481 ◽

1999 ◽

Vol 81 (03) ◽

pp. 378-381 ◽

Cited By ~ 41

Author(s):

Frank Brosstad ◽

Thore Egeland ◽

Tor Egge ◽

Erik Schrumpf ◽

Kirsten Boberg

Keyword(s):

Liver Biopsy ◽

Bleeding Time ◽

Hemoglobin Concentration ◽

Additional Information ◽

Risk Of Bleeding ◽

Prolonged Bleeding ◽

Prolonged Bleeding Time ◽

Increased Risk ◽

Patient Groups ◽

Risk Of Hemorrhage

SummaryBleeding time determination is not advised as a general preoperative hemostasis screening test, but it might be useful in some patient groups. Patients referred for liver biopsy frequently have coagulation disturbances and are at risk of hemorrhage. In this prospective study 219 liver biopsies were carried out regardless of a prolonged bleeding time, but with minimum requirements for hemoglobin concentration, platelet count, and tests of the internal and external coagulation pathways. The bleeding time was prolonged in the case of 48 (22%) of the biopsies. Significant bleeding as defined by a hemoglobin decrease of ≥2.0 g/dl occurred in nine patients. Three of these patients were bone marrow transplanted. Patients with a prolonged bleeding time carried a five times higher risk of bleeding (odds ratio = 5.0; confidence interval = 1.1-21.8; p = 0.019). We conclude that the bleeding time may give additional information on the risk of bleeding in some patient groups undergoing liver biopsy.

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A significant interaction between ketorolac and dalteparin sodium resulted in prolonged bleeding time

Reactions Weekly ◽

10.2165/00128415-199907730-00007 ◽

1999 ◽

Vol &NA; (773) ◽

pp. 4

Author(s):

&NA;

Keyword(s):

Significant Interaction ◽

Bleeding Time ◽

Dalteparin Sodium ◽

Prolonged Bleeding ◽

Prolonged Bleeding Time

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Prolonged bleeding time in experimental cirrhosis: role of nitric oxide

Journal of Hepatology ◽

10.1016/s0168-8278(99)80105-6 ◽

1999 ◽

Vol 30 (3) ◽

pp. 456-460 ◽

Cited By ~ 18

Author(s):

Liliana Albornoz ◽

Juan Carlos Bandi ◽

Juan Carlos Otaso ◽

Oscar Laudanno ◽

Ricardo Mastai

Keyword(s):

Nitric Oxide ◽

Bleeding Time ◽

Experimental Cirrhosis ◽

Prolonged Bleeding ◽

Prolonged Bleeding Time

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Absence of Correlation between Haemorrhagic Lymph and Prolonged Bleeding Time During Experimental Thrombocytopenia

10.1055/s-0039-1689623 ◽

1975 ◽

Cited By ~ 1

Author(s):

I. Aursnes

Keyword(s):

Bleeding Time ◽

Critical Level ◽

Blood Platelets ◽

Red Cells ◽

Whole Body ◽

Prolonged Bleeding ◽

Prolonged Bleeding Time ◽

Platelet Concentration ◽

Low Levels ◽

Heavy Dose

The level of circulating blood platelets below which a prolonged bleeding time can be found, is somewhat dependent on the age of the platelets at hand. However, when studying the appearance of red cells in the lymph of animals during experimental thrombocytopenia, no such critical level could be found at all (I. Aursncs, Scand. J. Haemat. 13, 184-195). Thus very low levels of circulating blood platelets with markedly prolonged bleeding time can be seen in animals with no red cell leakage to their lymph.Those observations have now been somewhat extended by observing the same two-pmeters in rabbits soon after their production of blood platelets has been completely stopped by a more heavy dose of whole body irradiation. Abnormal leakage of red cells to lymph (drained from the ears which had been shielded during the irradiation) the often occurred at levels of 100-400,000 platelets per μl, whereas the bleeding times in the same animals were usually not significantly prolonged until the platelet concentration fell below 50,000 per μl blood.An explanation for the two described phenomena would be that the vascular supportive effect and the haemostatic effect of blood platelets are dependent on two different mechanisms.

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Consistency of responses to separate desmopressin infusions in patients with storage pool disease and isolated prolonged bleeding time

Thrombosis Research ◽

10.1016/0049-3848(93)90041-l ◽

1993 ◽

Vol 69 (4) ◽

pp. 407-412 ◽

Cited By ~ 10

Author(s):

Giancarlo Castaman ◽

Francesco Rodeghiero

Keyword(s):

Bleeding Time ◽

Storage Pool ◽

Prolonged Bleeding ◽

Prolonged Bleeding Time ◽

Storage Pool Disease

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The Effect of Heparin on the Bleeding Time

Thrombosis and Haemostasis ◽

10.1055/s-0038-1654522 ◽

1960 ◽

Vol 04 (03) ◽

pp. 389-399 ◽

Cited By ~ 6

Author(s):

P. F Hjort ◽

C. F Borchgrevink ◽

O. H Iversen ◽

H Stormorken

Keyword(s):

Bleeding Time ◽

Fibrin Formation ◽

Prolonged Bleeding ◽

Prolonged Bleeding Time ◽

Rats And Mice ◽

Aggregation Of Platelets ◽

Sensitive Method

Summary and Conclusions1. Moderate doses of heparin often prolonged the bleeding time in men, rats and mice. The bleeding was wavelike, and a sensitive method was necessary to demonstrate the prolongation.2. Large doses gave a prolonged bleeding time, and the bleeding was often profuse and continuous.3. Heparin did not produce thrombocytopenia. Moderate doses probably prevent viscous metamorphosis and fibrin formation, resulting in large but inefficient platelet plugs. Large doses may also interfere with the aggregation of platelets, preventing the formation of platelet plugs.

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