FISH – The Best Technique in Characterization of Prenatally Detected Small Supernumerary Marker Chromosomes (sSMC)

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Frenny J Sheth ◽  
Naznin L ◽  
Liehr T ◽  
Sheth JJ
Keyword(s):  
Marker Chromosomes ◽  
Small Supernumerary Marker Chromosomes ◽  
Supernumerary Marker Chromosomes

Characterization of three small supernumerary marker chromosomes (sSMC) in humans

2012 ◽  
Vol 26 (1) ◽  
pp. 106-108 ◽  
Author(s):  
Jian Ou ◽  
Wei Wang ◽  
Thomas Liehr ◽  
Elisabeth Klein ◽  
Ahmed B. Hamid ◽  
...  
Keyword(s):  
Marker Chromosomes ◽  
Small Supernumerary Marker Chromosomes ◽  
Supernumerary Marker Chromosomes

scholarly journals Characterization of Small Supernumerary Marker Chromosomes By A Simple Molecular and Molecular Cytogenetics Approach

2007 ◽  
Vol 10 (1) ◽  
pp. 33-37 ◽  
Author(s):  
T Liehr ◽  
V Trifonov ◽  
A Polityko ◽  
L Brecevic ◽  
K Mrasek ◽  
...  
Keyword(s):  
Molecular Cytogenetics ◽  
Metaphase Spread ◽  
Marker Chromosomes ◽  
Chromosomal Origin ◽  
Chromosome 20 ◽  
Small Supernumerary Marker Chromosomes ◽  
Supernumerary Marker Chromosomes

Characterization of Small Supernumerary Marker Chromosomes By A Simple Molecular and Molecular Cytogenetics ApproachSmall supernumerary marker chromosomes (sSMC) are still a major problem especially in prenatal cytogenetic diagnostics and counseling. These structurally abnormal chromosomes cannot be identified or characterized unambiguously by conventional banding cytogenetics alone, and are generally about the size of or smaller than a chromosome 20 in the same metaphase spread. We describe a straightforward algorithm, based on data from 2,211 reported cases (http://www.markerchromosomes.ag.vu) to quickly characterize the sSMC's chromosomal origin.

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