scholarly journals Transportation of DNA Molecule by Dielectrophoretic Force in Micro Flow Channel. Utilization of Conformational Transition in the Higher Order Structure of DNA.

1996 ◽  
Vol 116 (9) ◽  
pp. 387-394
Author(s):  
Keisuke MORISHIMA ◽  
Toshio FUKUDA ◽  
Fumihito ARAI ◽  
Kenichi YOSHIKAWA
Keyword(s):  
Conformational Transition ◽  
Higher Order ◽  
Flow Channel ◽  
Order Structure ◽  
Channel Utilization ◽  
Dielectrophoretic Force ◽  
Dna Molecule ◽  
Micro Flow

scholarly journals Conformational Transition of Higher-Order Structure in Single DNA Molecule.

1995 ◽  
Vol 52 (12) ◽  
pp. 753-764 ◽  
Author(s):  
Yukiko MATSUZAWA ◽  
Kenichi YOSHIKAWA
Keyword(s):  
Conformational Transition ◽  
Higher Order ◽  
Order Structure ◽  
Dna Molecule ◽  
Single Dna Molecule

1M1600 Change of higher-order structure of DNA molecule inhibits the action of a restriction endonuclease

2002 ◽  
Vol 42 (supplement2) ◽  
pp. S78
Author(s):  
H. Oana ◽  
K. Tsumoto ◽  
Y. Yoshikawa
Keyword(s):  
Restriction Endonuclease ◽  
Higher Order ◽  
Order Structure ◽  
Dna Molecule

Isolation of genomic DNA molecule from a single cell and control its higher order structure using optical tweezers

2005 ◽  
Author(s):  
Hidehiro Oana ◽  
Isao Hagiya ◽  
Masao Washizu ◽  
Koji Kubo ◽  
Kenichi Yoshikawa ◽  
...  
Keyword(s):  
Single Cell ◽  
Optical Tweezers ◽  
Genomic Dna ◽  
Higher Order ◽  
Order Structure ◽  
Dna Molecule ◽  
And Control

Macrocycles of Higher Ortho-Phenylenes: Assembly and Folding

2019 ◽  
Author(s):  
Zacharias Kinney ◽  
Viraj Kirinda ◽  
Scott Hartley
Keyword(s):  
Chemical Shift ◽  
Higher Order ◽  
Order Structure ◽  
Complex Geometries ◽  
Spatial Relationships ◽  
Predominant Species ◽  
Bite Angle ◽  
Direct Assembly

<p>Higher-order structure in abiotic foldamer systems represents an important but largely unrealized goal. As one approach to this challenge, covalent assembly can be used to assemble macrocycles with foldamer subunits in well-defined spatial relationships. Such systems have previously been shown to exhibit self-sorting, new folding motifs, and dynamic stereoisomerism, yet there remain important questions about the interplay between folding and macrocyclization and the effect of structural confinement on folding behavior. Here, we explore the dynamic covalent assembly of extended <i>ortho</i>-phenylenes (hexamer and decamer) with rod-shaped linkers. Characteristic <sup>1</sup>H chemical shift differences between cyclic and acyclic systems can be compared with computational conformer libraries to determine the folding states of the macrocycles. We show that the bite angle provides a measure of the fit of an <i>o</i>-phenylene conformer within a shape-persistent macrocycle, affecting both assembly and ultimate folding behavior. For the <i>o</i>-phenylene hexamer, the bite angle and conformer stability work synergistically to direct assembly toward triangular [3+3] macrocycles of well-folded oligomers. For the decamer, the energetic accessibility of conformers with small bite angles allows [2+2] macrocycles to be formed as the predominant species. In these systems, the <i>o</i>-phenylenes are forced into unusual folding states, preferentially adopting a backbone geometry with distinct helical blocks of opposite handedness. The results show that simple geometric restrictions can be used to direct foldamers toward increasingly complex geometries.</p>

Macrocycles of Higher ortho-Phenylenes: Assembly and Folding

2019 ◽  
Author(s):  
Zacharias Kinney ◽  
Viraj Kirinda ◽  
Scott Hartley
Keyword(s):  
Chemical Shift ◽  
Higher Order ◽  
Order Structure ◽  
Complex Geometries ◽  
Spatial Relationships ◽  
Predominant Species ◽  
Bite Angle ◽  
Direct Assembly

<p>Higher-order structure in abiotic foldamer systems represents an important but largely unrealized goal. As one approach to this challenge, covalent assembly can be used to assemble macrocycles with foldamer subunits in well-defined spatial relationships. Such systems have previously been shown to exhibit self-sorting, new folding motifs, and dynamic stereoisomerism, yet there remain important questions about the interplay between folding and macrocyclization and the effect of structural confinement on folding behavior. Here, we explore the dynamic covalent assembly of extended <i>ortho</i>-phenylenes (hexamer and decamer) with rod-shaped linkers. Characteristic <sup>1</sup>H chemical shift differences between cyclic and acyclic systems can be compared with computational conformer libraries to determine the folding states of the macrocycles. We show that the bite angle provides a measure of the fit of an <i>o</i>-phenylene conformer within a shape-persistent macrocycle, affecting both assembly and ultimate folding behavior. For the <i>o</i>-phenylene hexamer, the bite angle and conformer stability work synergistically to direct assembly toward triangular [3+3] macrocycles of well-folded oligomers. For the decamer, the energetic accessibility of conformers with small bite angles allows [2+2] macrocycles to be formed as the predominant species. In these systems, the <i>o</i>-phenylenes are forced into unusual folding states, preferentially adopting a backbone geometry with distinct helical blocks of opposite handedness. The results show that simple geometric restrictions can be used to direct foldamers toward increasingly complex geometries.</p>

Sign in / Sign up

Export Citation Format

Share Document