scholarly journals The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms

2014 ◽  
Vol 109 (3) ◽  
pp. 362-364 ◽  
Author(s):  
Policarpo Ademar Sales Júnior ◽  
Celso Oliveira Rezende Júnior ◽  
Mireille Le Hyaric ◽  
Mauro Vieira de Almeida ◽  
Alvaro José Romanha
Keyword(s):  
Trypanosoma Cruzi ◽  
Amino Alcohols ◽  
Vitro Activity ◽  
In Vitro Activity

scholarly journals In vitro activity of Etanidazole against the protozoan parasite Trypanosoma cruzi

2004 ◽  
Vol 99 (2) ◽  
pp. 233-235 ◽  
Author(s):  
Patricia B Petray ◽  
María J Morilla ◽  
Ricardo S Corral ◽  
Eder L Romero
Keyword(s):  
Trypanosoma Cruzi ◽  
Protozoan Parasite ◽  
Vitro Activity ◽  
In Vitro Activity

scholarly journals Differential in vitro activity of the DNA topoisomerase inhibitor idarubicin against Trypanosoma rangeli and Trypanosoma cruzi

2012 ◽  
Vol 107 (7) ◽  
pp. 946-950 ◽  
Author(s):  
Momodou Jobe ◽  
Charles Anwuzia-Iwegbu ◽  
Ama Banful ◽  
Emma Bosier ◽  
Mubeen Iqbal ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Trypanosoma Rangeli ◽  
Dna Topoisomerase ◽  
Topoisomerase Inhibitor

Manganese(II) complexes with N4-methyl-4-nitrobenzaldehyde, N4-methyl-4-nitroacetofenone, and N4-methyl-4-nitrobenzophenone thiosemicarbazone: Investigation of in vitro activity against Trypanosoma cruzi

Polyhedron ◽  
2010 ◽  
Vol 29 (10) ◽  
pp. 2232-2238 ◽  
Author(s):  
Denise da Gama Jaén Batista ◽  
Patrícia Bernardino da Silva ◽  
Daniela R. Lachter ◽  
Renata S. Silva ◽  
Ricardo Q. Aucelio ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Vitro Activity ◽  
In Vitro Activity

Aromatic guanyl hydrazones: Synthesis, structural studies and in vitro activity against Trypanosoma cruzi

1995 ◽  
Vol 5 (24) ◽  
pp. 3079-3084 ◽  
Author(s):  
J.C. Messeder ◽  
L.W. Tinoco ◽  
J.D. Figueroa-Villar ◽  
E.M. Souza ◽  
R. Santa Rita ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Vitro Activity ◽  
Structural Studies ◽  
In Vitro Activity

1,4-Bis(alkylamino)benzo[g]phthalazines able to form dinuclear complexes of Cu(II) which as free ligands behave as SOD inhibitors and show efficient in vitro activity against Trypanosoma cruzi

2007 ◽  
Vol 15 (5) ◽  
pp. 2081-2091 ◽  
Author(s):  
Marinela Rodríguez-Ciria ◽  
Ana M. Sanz ◽  
María J.R. Yunta ◽  
Fernando Gómez-Contreras ◽  
Pilar Navarro ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Vitro Activity ◽  
Dinuclear Complexes ◽  
In Vitro Activity

scholarly journals Trypanosoma cruzi: in vitro activity of Epoxy-α-Lap, a derivative of α-lapachone, on trypomastigote and amastigote forms

2009 ◽  
Vol 122 (2) ◽  
pp. 91-96 ◽  
Author(s):  
S.C. Bourguignon ◽  
H.C. Castro ◽  
D.O. Santos ◽  
C.R. Alves ◽  
V.F. Ferreira ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Vitro Activity ◽  
In Vitro Activity

scholarly journals In vitro activity of thienyl-2-nitropropene compounds against Trypanosoma cruzi

2009 ◽  
Vol 104 (7) ◽  
pp. 980-985 ◽  
Author(s):  
Cristina Herrera ◽  
Gabriel A Vallejos ◽  
Randall Loaiza ◽  
Rodrigo Zeledón ◽  
Andrea Urbina ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Vitro Activity ◽  
In Vitro Activity

scholarly journals Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae)

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Orlando G. Elso ◽  
Maria Clavin ◽  
Natalia Hernandez ◽  
Tomás Sgarlata ◽  
Hernán Bach ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Leishmania Infantum ◽  
Sesquiterpene Lactones ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Ic50 Values

The dewaxed dichloromethane extract of Urolepis hecatantha and the compounds isolated from it were tested for their in vitro activity on Trypanosoma cruzi epimastigotes and Leishmania infantum promastigotes. The extract of U. hecatantha showed activity against both parasites with IC50 values of 7 µg/mL and 31 µg/mL, respectively. Fractionation of the dichloromethane extract led to the isolation of euparin, jaceidin, santhemoidin C, and eucannabinolide. The sesquiterpene lactones eucannabinolide and santhemoidin C were active on T. cruzi with IC50 values of 10 ± 2 µM (4.2 µg/mL) and 18 ± 3 µM (7.6 µg/mL), respectively. Euparin and santhemoidin C were the most active on L. infantum with IC50 values of 18 ± 4 µM (3.9 µg/mL) and 19 ± 4 µM (8.0 µg/mL), respectively. Eucannabinolide has also shown drug-like pharmacokinetic and toxicity properties.

scholarly journals Antiparasitic properties of homoallylamines and related compounds

2006 ◽  
Vol 51 (1) ◽  
Author(s):  
Alicia Gómez-Barrio ◽  
David Montero-Pereira ◽  
Juan Nogal-Ruiz ◽  
José Escario ◽  
Susana Muelas-Serrano ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Trichomonas Vaginalis ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Antiparasitic Activity ◽  
Murine Macrophages ◽  
Related Compounds

AbstractA study of some antiparasitic properties of several homoallylamines and related tetrahydroquinolines and quinolines, previously described, was carried out using in vitro activity assays against the epimastigote form of Trypanosoma cruzi and against Trichomonas vaginalis. Unspecific cytotoxicity against murine macrophages was also studied. Although the antichagasic and trichomonacidal activities are not comparable to those of the standard drugs, nifurtimox and metronidazole, some of the compounds exhibit an interesting specific antiparasitic activity.

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