Tremorgenic syndrome caused by Ipomoea pes caprae in cattle

ABSTRACT: Poisonous plants are a significant cause of death among adult cattle in Brazil. Plants that affect the central nervous system are widely spread throughout the Brazilian territory and comprise over 30 toxic species, including the genus Ipomoea, commonly associated with a lysosomal storage disease and a tremorgenic syndrome in livestock. We describe natural and experimental Ipomoea pes caprae poisoning in cattle from a herd in the Northside of Rio de Janeiro, Brazil. Affected cattle presented episodes of severe ataxia, abnormal posture followed by falling, muscular tremor, contraction, and spasticity, more prominent in the limbs, intensified by movement and forthcoming, and recumbence. Grossly, a substantial amount of leaves and petioles were found in the rumen. Histopathological examination showed degenerative neuronal changes, mostly in cerebellar Purkinje cells, which were confirmed with Bielschowsky silver. The characteristic clinical changes and mild histological lesion strongly suggested a tremorgenic syndrome. Lectin- immunohistochemistry evaluation reinforced this hypothesis; all lectins tested failed to react with affect neurons and Purkinje cells, which ruled out an underlying lysosomal storage disease. One calf given I. pes caprae leaves experimentally developed clinical signs similar to natural cases. On the 28th day of the experiment, the plant administration was suspended, and the calf recovered within four days. I. pes caprae’s spontaneous tremorgenic syndrome in cattle is conditioned to exclusive feeding for several months. We were able to experimentally reproduce toxic clinical signs 12 days following the ingestion.

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Positioning Head Tilt in Canine Lysosomal Storage Disease: A Retrospective Observational Descriptive Study

Frontiers in Veterinary Science ◽

10.3389/fvets.2021.802668 ◽

2021 ◽

Vol 8 ◽

Author(s):

Shinji Tamura ◽

Yumiko Tamura ◽

Yuya Nakamoto ◽

Daisuke Hasegawa ◽

Masaya Tsuboi ◽

...

Keyword(s):

Lysosomal Storage Disease ◽

Storage Disease ◽

Neuronal Degeneration ◽

Neuronal Ceroid Lipofuscinosis ◽

Clinical Signs ◽

Head Tilt ◽

Vestibular Nuclei ◽

Lysosomal Storage ◽

Gm2 Gangliosidosis ◽

Gm1 Gangliosidosis

Positioning head tilt is a neurological sign that has recently been described in dogs with congenital cerebellar malformations. This head tilt is triggered in response to head movement and is believed to be caused by a lack of inhibition of the vestibular nuclei by the cerebellar nodulus and ventral uvula (NU), as originally reported cases were dogs with NU hypoplasia. We hypothesized that other diseases, such as lysosomal storage diseases that cause degeneration in the whole brain, including NU, may cause NU dysfunction and positioning head tilt. Videos of the clinical signs of canine lysosomal storage disease were retrospectively evaluated. In addition, post-mortem NU specimens from each dog were histopathologically evaluated. Nine dogs were included, five with lysosomal storage disease, two Chihuahuas with neuronal ceroid lipofuscinosis (NCL), two Border Collies with NCL, one Shikoku Inu with NCL, two Toy Poodles with GM2 gangliosidosis, and two Shiba Inus with GM1 gangliosidosis. Twenty-eight videos recorded the clinical signs of the dogs. In these videos, positioning head tilt was observed in seven of nine dogs, two Chihuahuas with NCL, one Border Collie with NCL, one Shikoku Inu with NCL, one Toy Poodle with GM2 gangliosidosis, and two Shiba Inus with GM1 gangliosidosis. Neuronal degeneration and loss of NU were histopathologically confirmed in all diseases. As positioning head tilt had not been described until 2016, it may have been overlooked and may be a common clinical sign and pathophysiology in dogs with NU dysfunction.

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Faculty Opinions recommendation of Oncogenic effects of germline variants in lysosomal storage disease genes.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.736262531.793563285 ◽

2019 ◽

Author(s):

Fowzan S Alkuraya

Keyword(s):

Lysosomal Storage Disease ◽

Storage Disease ◽

Disease Genes ◽

Lysosomal Storage ◽

Germline Variants

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Is there a role for scintigraphic imaging of bone manifestations in Gaucher disease?

Nuklearmedizin ◽

10.3413/nukmed-0142 ◽

2008 ◽

Vol 47 (06) ◽

pp. 239-247 ◽

Cited By ~ 8

Author(s):

S. Kohlfürst ◽

H. J. Gallowitsch ◽

E. Kresnik ◽

P. Lind ◽

A. B. Mehta ◽

...

Keyword(s):

Bone Marrow ◽

Lysosomal Storage Disease ◽

Gaucher Disease ◽

Storage Disease ◽

Lysosomal Storage ◽

Scintigraphic Imaging ◽

Imaging Methods ◽

X Ray ◽

Deficient Activity

SummaryGaucher disease is the most prevalent inherited, lysosomal storage disease and is caused by deficient activity of the enzyme β-glucocerebrosidase. Bone and bone marrow alterations are frequent in the most prevalent non-neuronopathic form of Gaucher disease. Imaging of bone manifestations in Gaucher disease is performed by a variety of imaging methods, conventional X-ray and MRI as the most frequently and most important ones. However, different modalities of scintigraphic imaging have also been used. This article gives an overview on scintigraphic imaging with respect to bone manifestations in Gaucher disease discussing the advantages and limitations of scintigraphic imaging in comparison to other imaging methods.

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