scholarly journals Testicular tumors in 190 dogs: clinical, macroscopic and histopathological aspects

2020 ◽  
Vol 40 (7) ◽  
pp. 525-535
Author(s):  
Harlan H.L. Nascimento ◽  
Alex dos Santos ◽  
Amanda L. Prante ◽  
Eryca C. Lamego ◽  
Luís A.S. Tondo ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Cell Tumor ◽  
Testicular Neoplasms ◽  
Histopathological Analysis ◽  
Testicular Neoplasm ◽  
Sertoli Cell Tumor ◽  
Testicular Tumors ◽  
Biopsy Specimens ◽  
Different Types ◽  
Santa Maria

ABSTRACT: This study aimed to characterize the prevalence and clinical, macroscopic and histopathological aspects of dogs affected by testicular tumors based on biopsy specimens from the Laboratório de Patologia Veterinária of the Universidade Federal de Santa Maria (LPV-UFSM) over 19 years. Parameters regarding the age, size, and breed of the affected dogs were also established. Of all dogs with some type of neoplasm submitted to histopathological analysis at the LPV over these 19 years (n=1,900), 213 (11.2%) had at least one testicular neoplasm. The tissues of 190 dogs (with 220 neoplasms) were available for histological reassessment. The dogs in this study had different types of testicular tumors with relatively similar frequencies. In descending order, the most frequent testicular neoplasms were seminomas (88/220), Leydig (interstitial) cell tumor (LCT; 64/220), Sertoli cell tumor (SCT; 61/220), and mixed germ cell-sex cord stromal tumor (MGSCT) (07/220). Among the dogs of defined breed (119 cases), large breeds had the largest number of cases (50/119), followed by small (47/119) and medium-sized (22/119) breeds. The ages of dogs affected by testicular tumors ranged from 10 months to 18 years. Increased testicular volume was the most common clinical manifestation. Eleven dogs presented information about clinical signs suggestive of hyperestrogenism syndrome (feminization). In seminomas, the diffuse pattern predominated over the intratubular pattern. Two sites (luminal and basal compartments) suggestive of the onset of neoplastic transformations in germ cells were observed in intratubular seminomas. They corroborate the hypothesis that canine seminomas possibly have pathogenesis similar to that observed in human spermatocytic seminomas. The SCTs and LCTs presented high cell morphology variation. SCTs had neoplastic cells organized in five different histological arrangements. As for LCT, solid-diffuse and cystic-vascular histological patterns were the most commonly observed. Through this study, it was possible to establish some of the leading clinical, macroscopic, and histopathological aspects of testicular neoplasms diagnosed over 19 years in the area covered by the LPV-UFSM.

Testicular Tumors—Some New and a Few Perennial Problems

2008 ◽  
Vol 132 (4) ◽  
pp. 548-564 ◽  
Author(s):  
Robert H. Young
Keyword(s):  
Germ Cell ◽  
Sertoli Cell ◽  
Leydig Cell ◽  
Yolk Sac ◽  
Cell Tumor ◽  
Yolk Sac Tumor ◽  
Female Gonad ◽  
Sertoli Cell Tumor ◽  
Older Patient ◽  
Testicular Tumors

Abstract The histopathology of testicular tumors is presented, emphasizing new, unusual, or underemphasized aspects. Within the category of seminoma of the usual type, the recent literature has drawn attention to the presence in occasional tumors of solid or hollow tubules or spaces of varying sizes and shape that may result in cribriform or microcystic patterns, causing potential confusion with other neoplasms, most notably Sertoli cell tumor or yolk sac tumor. Although regions of typical neoplasia and awareness of this phenomenon usually will be diagnostic, immunohistochemistry may play a role in excluding Sertoli cell tumor or yolk sac tumor. Although immunohistochemistry can play an undoubted helpful role in this and selected other areas of testicular tumor evaluation, careful evaluation of the gross and routine microscopic features will solve the vast majority of diagnostic problems. An excellent review of immunohistochemistry in this area by R. E. Emerson, MD, and T. M. Ulbright, MD, is cited herein. Spermatocytic seminoma remains a crucial pitfall in diagnosis, and the pathologist must always be alert to the possible diagnosis when looking at a seminomatous neoplasm, particularly in an older patient, although about one third of these tumors occur in the usual seminoma age range. The embryonal carcinoma has a great diversity of patterns, which are briefly noted. The enigmatic and picturesque tumor, polyembryoma, which virtually never occurs in pure form but may be a confusing component of a variety of mixed germ cell tumors, is discussed and illustrated. The phenomenon of burnt-out germ cell neoplasia is also briefly noted and an excellent recent contribution is referred to. Within the sex cord–stromal family of neoplasms, recent contributions and elaborations of unusual morphologic features of Leydig cell tumors and Sertoli cell tumors are presented. Within the Leydig cell family, cyst formation, adipose metaplasia, calcification or ossification, and spindle cell patterns may be particularly confusing, and in the Sertoli cell family, a great array of patterns caused by differing admixtures of tubular, solid, and stromal components occur. The peculiar lesion, intratubular large cell hyalinizing Sertoli cell tumor, of young boys with Peutz-Jeghers syndrome, is briefly discussed. Some of the problems in the family of hematopoietic neoplasms are reviewed, these processes posing diverse problems in differential diagnosis and their correct recognition having crucial therapeutic implications. Although secondary tumors to the testis have not received the same attention in the literature as the similar phenomenon in the female gonad, remarkable examples of testicular spread of diverse neoplasms, usually carcinoma but rarely melanoma, are seen, and the pathologist should be alert to this possibility, particularly when examining an unusual morphology in an older patient. Finally, a few comments are made on the common paratesticular neoplasm, the adenomatoid tumor, highlighting its varied patterns and recent description of some of the issues that may arise when they undergo total or subtotal infarction.

Medullary bone in male budgerigars (Melopsittacus undulatus) with testicular neoplasms

2022 ◽  
pp. 030098582110691
Author(s):  
Nathan K. Hoggard ◽  
Linden E. Craig
Keyword(s):  
Bone Density ◽  
Interstitial Cell ◽  
Egg Laying ◽  
Cell Tumor ◽  
Mature Male ◽  
Testicular Neoplasms ◽  
Testicular Neoplasm ◽  
Medullary Bone ◽  
Sustentacular Cell ◽  
Sexually Mature

Medullary bone is a calcium-rich, labile bone normally occurring in female birds with each egg-laying cycle. The stimulus for formation of medullary bone is, in part, the cyclic increase in serum estrogens produced by preovulatory ovarian follicles. Increased bone density due to formation of medullary bone, particularly in pneumatic bones, has been termed polyostotic hyperostosis, even if physiologic. This study investigated the formation of medullary bone in nonpneumatic (femur) and pneumatic (humerus) bones in sexually mature male budgerigars submitted for autopsy. Of the 21 sexually mature male budgerigars submitted for autopsy, 7 (33%) had medullary bone in 1 or more bones examined. All 7 male budgerigars with medullary bone had a testicular neoplasm, which was morphologically consistent with a testicular sustentacular cell tumor, seminoma, or interstitial cell tumor. Medullary bone was not present in the 14 cases with other diseases. Medullary bone formation in pneumatic and nonpneumatic bones can occur in male budgerigars with testicular neoplasms. Radiographic increases in medullary bone density, particularly in the humerus, could provide antemortem indication of testicular neoplasia in male budgerigars.

Sclerosing sertoli cell tumor. An infrequent type of testicular neoplasm

2010 ◽  
Vol 34 (8) ◽  
pp. 732-734
Author(s):  
C.J. Yánez Benítez ◽  
C. Valero Valdivieso ◽  
J.I. Sanz Vélez ◽  
M. Marigil Gómez
Keyword(s):  
Sertoli Cell ◽  
Cell Tumor ◽  
Testicular Neoplasm ◽  
Sertoli Cell Tumor

scholarly journals Histopathological analysis of testicular tumors

2012 ◽  
Vol 2 (4) ◽  
pp. 301-304
Author(s):  
S Karki ◽  
RR Bhatta
Keyword(s):  
Germ Cell ◽  
Undescended Testis ◽  
Germ Cell Tumors ◽  
Cell Tumor ◽  
Histopathological Analysis ◽  
Testicular Tumors ◽  
Non Hodgkin Lymphoma ◽  
Pertinent Data ◽  
Testicular Lesions ◽  
Mixed Germ Cell Tumors

Background: Testicular cancers are rare in most countries. However, in many western countries its incidence has been increasing since the middle of the twentieth century. A definite geographic and racial distribution is seen in testicular tumors. The purpose of the study was to analyze the pattern and distribution of testicular cancers in one of the hospital in Nepal.Materials and methods: This was a retrospective study, in which cases were retrieved from the computer database between September 2006 and August 2011 in the department of Pathology. Pertinent data like age and histopathology of tumor were collected from the surgical pathology reports.Results: Testicular tumors were uncommon, comprising only 11.4% (8/70 cases) of all testicular lesions. Most of these tumors (50%) were seen between 4th and 5th decades. Germ cell tumors were the commonest tumors (62.5%), among which seminomas and mixed germ cell tumors were most frequently encountered, two cases each. Thirty percent of the biopsies consisted of undescended testis and none of them showed malignancy. Other tumors diagnosed were Non Hodgkin Lymphoma, leukemic infiltration and metastasis.Conclusion: Testicular tumors are uncommon in our population. As evident in other parts of the world, germ cell tumor was common in this study as well. However, unlike in Western population, no tumor was seen in undescended testis.Journal of Pathology of Nepal (2012) Vol. 2, 301-304DOI: http://dx.doi.org/10.3126/jpn.v2i4.6883

Sertoli cell tumor of the testis causing intracranial metastasis two years after orchiectomy. Report of a rare case and review of the literature

2021 ◽  
Author(s):  
Antonio Colamaria ◽  
Matteo Sacco ◽  
Giovanni Parbonetti ◽  
Nicola Pio Fochi ◽  
Francesco Carbone ◽  
...  
Keyword(s):  
Sertoli Cell ◽  
Present Report ◽  
Cell Tumor ◽  
Sertoli Cell Tumor ◽  
Testicular Tumors ◽  
Intracranial Metastasis ◽  
Leptomeningeal Involvement ◽  
Multiple Metastases ◽  
History Of ◽  
The Right

Abstract Sertoli cell tumor of the testis (SCTT) accounts for less than 1% of all testicular tumors with only 10% of cases exhibiting malignant behavior. In the present report, a case of malignant SCTT causing multiple metastases in a 32-year-old man is described. After being diagnosed and treated for bone and lymph nodes metastases, the patient presented with a brief history of worsening headaches and visual impairment. A head MRI demonstrated an extra-axial tumor located in the right fronto-parietal junction exhibiting avid contrast enhancement and leptomeningeal involvement. To the best of the authors’ knowledge, this represents the second case of intracranial metastasis from SCTT described to date.

scholarly journals Synchronous Leydig Cell Tumor and Seminoma in the Ipsilateral Testis

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Ifeyinwa E. Obiorah ◽  
Alexandra Kyrillos ◽  
Metin Ozdemirli
Keyword(s):  
Leydig Cell ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Testicular Neoplasms ◽  
Therapeutic Management ◽  
Germinal Epithelium ◽  
Testicular Tumors ◽  
Concurrent Development ◽  
Disease Entities ◽  
Leydig Cell Tumors

Leydig cell tumor is a rare sex cord tumor that accounts for 1–3% of all testicular neoplasms. Seminomas are more common and occur in 30–40% of testicular tumors. Leydig cell tumors are derived from undifferentiated gonadal mesenchyme and the concurrent development of the tumor and a seminoma which are derived from germinal epithelium in an ipsilateral testis is extremely rare. Here we report a case of ipsilateral Leydig cell tumor and seminoma occurring in a 38-year-old man with a left testicular mass. The key to diagnosis is dependent on histopathology and immunohistochemistry. To our knowledge, this is the first diagnosis of the two disease entities in a unilateral testis using immunohistochemistry. Increased awareness of the entity is important in order to distinguish Leydig cell tumor and seminomas from other malignancies due to difference in therapeutic management.

scholarly journals Pulmonar Granular Cell Tumor in a Horse

2021 ◽  
Vol 49 ◽  
Author(s):  
Diego Pereira de Araújo ◽  
Mariana Fagundes Bento ◽  
Eduardo De Paula Nascente ◽  
Helder Esteves Thomé ◽  
Veridiana Maria Brianezi Dignani de Moura
Keyword(s):  
Schwann Cells ◽  
Granular Cell Tumor ◽  
Periodic Acid ◽  
Clinical Signs ◽  
Neuroendocrine Differentiation ◽  
Granular Cell ◽  
Cell Tumor ◽  
Histopathological Analysis ◽  
Positive Staining ◽  
The Right

Background: The occurrence of neoplasms in horses is relatively low. Granular cell tumor is a seldom diagnosed neoplasm, usually benign, of mesenchymal origin. Controversies exist regarding its origin, which is possibly from Schwann cells or cells with neuroendocrine differentiation. Despite being one of the main primary neoplasms in the lungs of horses, the number of cases is low in comparison to that of secondary lung tumors. Thus, this study proposes to report the anatomopathological aspects in a horse with granular cell tumor of primary pulmonary origin. Case: An 11-year-old female Quarter Horse breed underwent exploratory right lateral thoracotomy after presenting with chronic respiratory changes. During the operation, tumor masses were found in the right and left caudal pulmonary lobes. Due to the severity of clinical respiratory signs and the extent of the lesions, the animal was subjected to euthanasia and anatomopathological examination. Upon necroscopic examination, a tumor mass was found in the middle third of the left caudal lobe, rounded to flattened, measuring 10.0 × 8.0 cm in height and length, white in color, of firm consistency, smooth and regular surface and rising to the lung surface. When sectioned, the mass showed to be composed of multiple firm and dense circular lobes, separated by a thin layer of connective tissue. The tumor invaded the lumen of nearby segmental and subsegmental bronchi, which were partially or totally obstructed by the mass. In the right lung, multiple similar nodules were observed, accompanied by peritumoral hemorrhage. Histopathological analysis of the new formation revealed a dense cluster of cells that expanded over the lung parenchyma. The neoplastic cells were pleomorphic, moderately cohesive, without defined borders, with abundant cytoplasm, densely eosinophilic and finely granular. Intracytoplasmic granules were well evidenced by periodic acid Schiff staining (PAS). The cell nucleus was rounded to oval, excentric, markedly basophilic and with dense chromatin. There was moderate anisocytosis and mild anisokaryosis, with rare mitotic figures. Immunohistochemical analysis revealed positive staining for anti-vimentin and anti-S100 antibodies, confirming the diagnosis of granular cell tumor.Discussion: Granular cell tumors have no predisposition as to breed, sex or age. However, most of the described cases are reported in female horses aged around 13 years. The advanced age of the diagnosed animals may be related to late definitive diagnosis, since the clinical signs are nonspecific and treated palliatively like other respiratory diseases. Macroscopically, this tumor is more common in the multinodular form and, as observed in this case, it has a greater capacity for infiltration. Histologically, the visualization of large, polygonal cells, with a wide cytoplasm containing eosinophilic granules leads to the diagnosis of granular cell tumor. However, PAS staining and immunohistochemical tests were essential for the diagnostic conclusion in this report, confirming the presence of cytoplasmic granules and the mesenchymal and neuroectodermal origin of this neoplasm, respectively. Thus, considering the low occurrence of pulmonary granular cell tumor, the description of this case contributes to the basis of the knowledge of medical-veterinary professionals about this tumor in its clinical and diagnostic aspects.Keywords: Schwann cells, immunohistochemistry, neoplasia, lung.Descritores: células de Schwann, imuno-histoquímica, neoplasia, pulmão.Título: Tumor de células granulares pulmonar em um equino 

scholarly journals Müller´s Duct Persistence Syndrome Associated with Cryptorchidism, Sertoli Cell Tumor and Pyometra in a Miniature Schnauzer

2019 ◽  
Vol 47 ◽  
Author(s):  
Tais Teixeira Zambarda ◽  
Renata Queiroz Stefani ◽  
Luciana Sonne ◽  
Álan Gomes Pöppl
Keyword(s):  
Sertoli Cell ◽  
Complete Blood Count ◽  
Histopathological Examination ◽  
Present Report ◽  
Abdominal Cavity ◽  
Hormone Secretion ◽  
Clinical Signs ◽  
Uterine Horn ◽  
Cell Tumor ◽  
Sertoli Cell Tumor

Background: Sexual development disturbances (SDD) are divided in SDD with XX genotype (SDD XX) and SDD with XY genotype (SDD XY). Among SDD XY, the Müller´s duct persistence syndrome (MDPS) is characterized by XY karyotype individuals with male external genitals; however, with internal female reproductive organs such as uterine horns, uterus, and cranial vagina portion. The MDPS cases and their related complications are considered very rare in veterinary medicine. The aim of the present case report is to describe the clinical and pathological aspects of a MDPS case associated with cryptorchidism, Sertoli cell tumor, and pyometra in a Miniature Schnauzer dog.Case: A 7-year-old male Miniature Schnauzer weighting 7 kg was brought to veterinary consultation due to owner´s complain of frequent vomiting, apathy, abdominal algia and progressive scrotal enlargement in the last two months. Physical exam reveals hyperthermia (39.7°C), discrete dehydration, enlarged popliteal lymph nodes as well as scrotum enlargement with only one palpable testicle. A blood sample collected for complete blood count showed regenerative anemia, thrombocytopenia, and neutrophilia with left shift in the leukogram. Abdominal ultrasound examination indicated the presence of a tubular structure filled by anechoic content extending from the scrotum to caudal abdomen. Moreover, a 6.39 x 8.54 cm heterogeneous mass in the medial mesogastric region became evident. The patient was hospitalized and submitted to exploratory laparotomy after 24 h due to rectal temperature increase (41°C), worsened abdominal pain and intense apathy. There was free purulent liquid in abdominal cavity and two uterine horns were documented. The left uterine horn passes through inguinal ring and both horns were filled by purulent material. At the right uterine horn extremity there was the mass previously document at ultrasound. The structures were removed and sent to histopathological examination. The microscopic exam confirmed testicular and uterine tissue; furthermore, a Sertoli cell tumor and pyometra were also characterized. The dog was kept at the hospital receiving fluid, antibiotics, analgesics, and anti-inflammatory therapy. After five days the animal was discharged with clear clinical recover. A sample for karyotyping was collected from the oral mucosa which reveals a XY karyotype in the dog. By this way it was concluded that the dog suffers from a SDD XY with MDPS associated to cryptorchidism, Sertoli cell tumor and pyometra.  Discussion: The MDPS cases are often associated with cryptorchidism and testicular tumors. Miniature Schnauzers is one of the most affected dog breeds with this condition, and the heritability pattern is already described. Most cases are identified in adult to old-aged dogs after vague clinical signs investigation such as apathy, anorexia and abdominal or inguinal enlargement, as observed in the present report. When Sertoli cell tumor are present, the hormone secretion pattern of this neoplasia may influence complications occurrence. Once higher estrogen levels may induce endometrial gland proliferation, hydrometra and pyometra are among these complications, as well as reduced hematopoiesis. Moreover, progesterone levels could be also increased favoring pyometra pathophysiology. By conclusion, despite very rare, MDPS should be investigated in Miniature Schnauzers with vague clinical signs, especially cryptorchidic ones. Karyotyping and histopathology were crucial to confirm the diagnosis. Moreover, no other case with MDPS, cryptorchidism, Sertoli cell tumor, and pyometra was found in the published literature consulted. 

scholarly journals Testicular Sparing Surgery For A 5-Year- Old Boy with Sertoli's Cell Tumour of the Testis: Case Report

2018 ◽  
Vol 26 (10) ◽  
pp. 192-196
Author(s):  
Karim AL-Araji
Keyword(s):  
Case Report ◽  
Sertoli Cell ◽  
Precocious Puberty ◽  
Testicular Tumor ◽  
Cell Tumor ◽  
Cell Tumour ◽  
Sertoli Cell Tumor ◽  
Testicular Tumors ◽  
Case Presentation

Introduction: Steroli's cell tumors SCT are the rare testicular tumor. Very few cases were published in the literature. A new case of Sertoli's cell tumor that is reported and treated by testicular sparing surgery. Case Presentation: A 5-year-old boy with Sertoli' cell tumor presents with gynaecomastia and precocious puberty. He was treated by successful testicular sparing surgery. Conclusions: SCTs are rare testicular tumors. Testicular sparing surgery can be applied.  

scholarly journals Sertoli Cell Tumor (SCT) in a Captive Black Bear (Ursus americanus)

2019 ◽  
Vol 6 (4) ◽  
pp. 77
Author(s):  
Elfadl ◽  
Park ◽  
Ullah ◽  
Youn ◽  
Chung ◽  
...  
Keyword(s):  
Sertoli Cell ◽  
Sertoli Cells ◽  
Ursus Americanus ◽  
Clinical Signs ◽  
Black Bear ◽  
Testicular Tissue ◽  
Cell Tumor ◽  
Cytokeratin 19 ◽  
Sertoli Cell Tumor ◽  
Rare Case Report

A black bear of 29-year-old (Ursus americanus) died unexpectedly in captivity without any gross lesions or clinical signs. We identified a firm, lobulated, yellowish tan, and well-circumscribed mass embedded inside the testicular tissue at the time of necropsy. The tumor sections exhibited soft necrotic and hemorrhagic areas beneath its capsule. Histologically, the tumor comprised Sertoli cells arranged in tubules and solid sheets supported by prominent fibrous connective tissues. The Sertoli cells were positive for vimentin and ER-β expression, whereas it showed negative staining for inhibin-α, cytokeratin 19, and S-100. To the best of our knowledge, this is the rare case report of testicular Sertoli cell tumor in black bear.

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