scholarly journals Vanishing bile duct syndrome in Hodgkin's disease: case report

2000 ◽  
Vol 118 (5) ◽  
pp. 154-157 ◽  
Author(s):  
Marta Soares Rossini ◽  
Irene Lorand-Metze ◽  
Gislaine Borba Oliveira ◽  
Cármino Antonio De Souza
Keyword(s):  
Case Report ◽  
Bile Duct ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
High Dose ◽  
Vanishing Bile Duct Syndrome ◽  
Disease Case ◽  
Vanishing Bile Duct ◽  
Portal Tracts ◽  
Duct Syndrome

CONTEXT: Liver damage is relatively common in patients affected by Hodgkin's disease. A smaller proportion of cases develops jaundice. Recently, the vanishing bile duct syndrome was described in Hodgkin's disease. The mechanisms of this severe complication have been poorly understood until now. OBJECTIVE: To describe a rare case of intra-hepatic cholestasis due to vanishing bile duct syndrome. DESIGN: Case report. CASE REPORT: A 38-year-old male patient affected by Hodgkin's disease. Liver biopsy showed no detectable Hodgkin's disease. Intra-hepatic cholestasis was found and none of the six portal tracts analyzed contained normal bile ducts. The treatment was based on conventional and high-dose escalation chemotherapy. The patient died from an irreversible liver failure while in complete remission from Hodgkin's disease.

scholarly journals A case report of vanishing bile duct syndrome after exposure to pexidartinib (PLX3397) and paclitaxel

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Sorbarikor Piawah ◽  
Colby Hyland ◽  
Sarah E. Umetsu ◽  
Laura J. Esserman ◽  
Hope S. Rugo ◽  
...  
Keyword(s):  
Case Report ◽  
Bile Duct ◽  
Vanishing Bile Duct Syndrome ◽  
Vanishing Bile Duct ◽  
Duct Syndrome

scholarly journals Stevens–Johnson syndrome and acute vanishing bile duct syndrome after the use of amoxicillin and naproxen in a child

2019 ◽  
Vol 47 (9) ◽  
pp. 4537-4543 ◽  
Author(s):  
Lu Li ◽  
Sujun Zheng ◽  
Yu Chen
Keyword(s):  
Case Report ◽  
Bile Duct ◽  
Epithelial Cells ◽  
Hypersensitivity Reaction ◽  
Stevens Johnson Syndrome ◽  
Drug Induced ◽  
Vanishing Bile Duct Syndrome ◽  
Johnson Syndrome ◽  
Vanishing Bile Duct ◽  
Duct Syndrome

We present the case report of a 6-year-old patient who developed Stevens–Johnson syndrome (SJS) and acute vanishing bile duct syndrome (VBDS) after taking oral amoxicillin and naproxen. SJS, an immune complex-mediated hypersensitivity reaction involving the skin and mucosa, is usually drug-induced, and it can lead to systemic symptoms. Acute VBDS is rare, often presenting with progressive loss of the intrahepatic biliary tract. VBDS is an immune-mediated bile duct-associated disease, and immunological damage to the bile duct system is an important mechanism for VBDS. Serious drug-induced liver injury (DILI) is also associated with immunity. The drug acts as a hapten with keratin on the surface of biliary epithelial cells. The autoantibodies produced by this action can damage the bile duct epithelial cells and cause the bile duct to disappear. SJS is a serious type of polymorphic erythema that is mainly considered to be a hypersensitivity reaction to drugs, and it may involve multiple factors.  The patient in this case report was treated with glucocorticoids, plasma exchange, ursodeoxycholic acid, and traditional Chinese medicine. He recovered completely within 5 months. This case report indicates that caution should be used because amoxicillin and naproxen can cause SJS and VBDS in children.

The first report of atovaquone/proguanil-induced vanishing bile duct syndrome: Case report and mini-review

2019 ◽  
Vol 32 ◽  
pp. 101439 ◽  
Author(s):  
Ashraf Abugroun ◽  
Ibett Colina Garcia ◽  
Fatima Ahmed ◽  
Steven Potts ◽  
Michael Flicker
Keyword(s):  
Case Report ◽  
Bile Duct ◽  
First Report ◽  
Vanishing Bile Duct Syndrome ◽  
Vanishing Bile Duct ◽  
Duct Syndrome

Vanishing Bile Duct Syndrome Occurring After Carbamazepine Administration: A Second Case Report

1994 ◽  
Vol 19 (3) ◽  
pp. 269-270 ◽  
Author(s):  
Chantal de Galoscy ◽  
Yves Horsmans ◽  
Jacques Rahier ◽  
Andre Pierre Geubel
Keyword(s):  
Case Report ◽  
Bile Duct ◽  
Vanishing Bile Duct Syndrome ◽  
Vanishing Bile Duct ◽  
Duct Syndrome

A fatal case of toxic epidermal necrolysis combined with vanishing bile duct syndrome and hemophagocytic lymphohistiocytosis

2021 ◽  
Author(s):  
Julian Wier ◽  
Alexandra Lacey ◽  
Haig Yenikomshian ◽  
T Justin Gillenwater
Keyword(s):  
Case Report ◽  
Bile Duct ◽  
Toxic Epidermal Necrolysis ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Fatal Case ◽  
Influenza B ◽  
Vanishing Bile Duct Syndrome ◽  
Vanishing Bile Duct ◽  
Duct Syndrome

Abstract This case report describes a case of fatal Toxic Epidermal Necrolysis complicated by both vanishing bile duct syndrome and hemophagocytic lymphohistiocytosis due to Influenza B infection. Here we highlight the potential for complex morbidity secondary to underlying autoimmune hypersensitivity. Furthermore, the stepwise progression of these pathologies is noted, with the initial epidermal lesions first progressing to cholestatic injury and then subsequently to the hematologic manifestations.

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