scholarly journals Relative Biological Effectiveness and Non-Poissonian Distribution of Dicentric Chromosome Aberrations following Californium-252 Neutron Exposures of Human Peripheral Blood Lymphocytes

2020 ◽  
Vol 195 (2) ◽  
Author(s):  
Laura C. Paterson ◽  
Andre Yonkeu ◽  
Fawaz Ali ◽  
Nicholas D. Priest ◽  
Douglas R. Boreham ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Chromosome Aberrations ◽  
Relative Biological Effectiveness ◽  
Human Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Dicentric Chromosome ◽  
Blood Lymphocytes ◽  
Human Peripheral Blood Lymphocytes ◽  
Biological Effectiveness

scholarly journals Assessment of Potential Clastogenic Effect of the Insecticide Mospilan® 20SP in Human Peripheral Blood Lymphocytes After in Vitro Exposure

2019 ◽  
Vol 63 (2) ◽  
pp. 21-24
Author(s):  
K. Ničová ◽  
V. Schwarzbacherová ◽  
M. Galdíková ◽  
B. Holečková
Keyword(s):  
Peripheral Blood ◽  
Chromosome Aberrations ◽  
Human Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes ◽  
Human Peripheral Blood Lymphocytes ◽  
Neonicotinoid Insecticide ◽  
Clastogenic Effect ◽  
Chromosome Aberration Test

Abstract Acetamiprid, that is known as the commercial formulation Mospilan® 20SP is the part of the neonicotinoid insecticide group and is widely used against various pests. In our study we assessed the potential clastogenic effects of Mospilan® in human peripheral blood lymphocytes in vitro using a chromosome aberration test. The lymphocytes were treated with acetamiprid in the concentration range of 5, 10, 25 and 50 µg.ml−1 for 24 and 48 h. After 24 h exposure, the insecticide induced statistically significant higher levels of chromosome aberrations from the concentration of 10 µg.ml−1 (P < 0.05 and P < 0.001) and a significant decrease in mitotic index (MI) at the concentrations of 25 and 50 µg.ml−1 (P < 0.05 and P < 0.01), respectively. After a 48 h exposure, we found a dose dependent increase in the percentage of chromosome aberrations at all concentrations (P < 0.05; P < 0.01 and P < 0.001) and a decrease in MI at concentrations of 25 and 50 µg.ml−1 (P < 0.05 and P < 0.01). Our results indicated that neonicotinoid insecticide formulations containing acetamiprid may have potential cytotoxic and genotoxic effects.

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