THE EFFECT OF BOVINE ANTERIOR PITUITARY EXTRACT ON LIPID MOBILIZATION IN THE RAT AND MAN

1969 ◽  
Vol 44 (3) ◽  
pp. 307-311 ◽  
Author(s):  
MARGARET J. HOLLAND
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Anterior Pituitary ◽  
Human Adipose Tissue ◽  
Pituitary Extract ◽  
Lipid Mobilization ◽  
Bovine Pituitary Extract ◽  
Fatty Acid Release ◽  
Acid Release

SUMMARY The lipolytic properties of a fraction of bovine pituitary extract were investigated. It was inactive in the rat and man under normal conditions, but after fasting for 48 hr., the extract promoted free fatty acid release from rat and human adipose tissue. Its significance as a fat-mobilizing hormone and its possible relationship to a fat-mobilizing substance excreted in the urine are discussed.

Glucose metabolism and mobilization of fatty acids by adipose tissue from obese mice

1961 ◽  
Vol 201 (1) ◽  
pp. 19-22 ◽  
Author(s):  
Bernard Leboeuf ◽  
Serene Lochaya ◽  
Nicole Leboeuf ◽  
Francis C. Wood ◽  
Jean Mayer ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Glucose Metabolism ◽  
Swiss Mice ◽  
Adipose Tissue In Vitro ◽  
Fatty Acid Release ◽  
Acid Release

Free fatty acid mobilization and glucose metabolism to CO2, to glyceride-glycerol, to fatty acids and to glycogen by adipose tissue in vitro were studied in genetically obese hyperglycemic mice (O-H), in goldthioglucose-injected obese Swiss mice and in their respective nonobese littermates. Tissue from O-H mice metabolizes less glucose than tissue from their nonobese littermates in absence of added hormone or in the presence of insulin (0.1 unit/ml) or epinephrine (10–4 m). In addition, there is also a diminished ability for insulin to inhibit and for epinephrine to augment free fatty acid release. No such differences were observed between tissues from goldthioglucose-injected obese Swiss mice and tissues from their lean littermates. Possible significance of these in vitro results with regard to the pathogenesis of the obese hyperglycemic syndrome is discussed.

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