MAINTENANCE OF MALE SEXUAL BEHAVIOUR BY COMBINED TREATMENT WITH OESTROGEN AND DIHYDROTESTOSTERONE IN CD-1 MICE

1975 ◽  
Vol 66 (2) ◽  
pp. 257-262 ◽  
Author(s):  
C. J. WALLIS ◽  
W. G. LUTTGE
Keyword(s):  
Adult Male ◽  
Sexual Behaviour ◽  
Mating Behaviour ◽  
Combined Treatment ◽  
Complete Loss ◽  
Male Mating ◽  
Intact Control ◽  
Male Sexual Behaviour ◽  
Oestradiol Benzoate

SUMMARY After castration, adult male sexually experienced CD-1 strain mice were treated with dihydrotestosterone (200 μg/day, DHT), oestradiol benzoate (1 μg/day, OB) or DHT (200 μg/ day) plus OB (1 μg/day). Oestradiol benzoate and the combined treatment DHT+OB maintained male sexual behaviour at levels comparable to a group of intact control mice, while DHT maintained behaviour at a lower level. Halving all hormone dosages resulted in a decrease in the number of OB-treated animals mating and a complete loss of mating in the DHT-treated animals. The decrease in dosage did not result in any change in the behaviour of the mice receiving both hormones. Adrenalectomy was found to have no effect on the mating behaviour of the OB-treated and untreated animals, but it did reduce the number of DHT+OB-treated animals mating. Thus, both OB alone and combined DHT+OB treatment can maintain male mating behaviour in castrated CD-1 strain mice and these effects do not appear to be due to the effects of oestradiol on the adrenal.

A COMPARISON OF THE EFFECTS OF NEONATALLY ADMINISTERED TESTOSTERONE, TESTOSTERONE PROPIONATE AND DIHYDROTESTOSTERONE ON AGGRESSIVE AND SEXUAL BEHAVIOUR IN THE FEMALE GOLDEN HAMSTER

1976 ◽  
Vol 69 (1) ◽  
pp. 23-31 ◽  
Author(s):  
A. P. PAYNE
Keyword(s):  
Sexual Behaviour ◽  
Golden Hamster ◽  
Testosterone Propionate ◽  
Mating Behaviour ◽  
Receptive Female ◽  
Male Mating ◽  
Aggressive Interactions ◽  
Golden Hamsters ◽  
Male Sexual Behaviour

SUMMARY Female golden hamsters received one of the following treatments on the day following birth: (i) 300 μg testosterone propionate in arachis oil, (ii) 300 μg testosterone in oil, (iii) 300 μg dihydrotestosterone in oil, or (iv) oil alone. As adults all animals underwent three tests for behaviour. First, while intact, females were observed in aggressive interactions with males. Secondly, after ovariectomy, females were primed with oestrogen + progesterone and tested for receptivity with a stud male. Thirdly, all ovariectomized females were primed with testosterone propionate and tested for male patterns of behaviour with a receptive female. Compared with the effects of oil administration (control), testosterone propionate administration resulted in increased aggressiveness and the capacity to show male patterns of sexual behaviour, together with a decreased capacity to show female patterns of sexual behaviour. Testosterone increased aggression and male sexual behaviour, but had no effects on receptivity, while dihydrotestosterone decreased some components of receptivity but had no effects on aggressiveness or the capacity to show male mating behaviour.

Pituitary and gonadal function in pubertal and adult male rabbits with pseudohermaphroditism secondary to immunization of mothers against testosterone

1984 ◽  
Vol 107 (4) ◽  
pp. 550-555
Author(s):  
G. Veyssière ◽  
M. Berger ◽  
Ch. Jean-Faucher ◽  
M. de Turckheim ◽  
Cl. Jean
Keyword(s):  
Adult Male ◽  
Sexual Behaviour ◽  
Sexual Maturation ◽  
Perinatal Period ◽  
Developmental Pattern ◽  
Plasma Testosterone ◽  
Testicular Function ◽  
Gonadal Function ◽  
Central Effects ◽  
Male Sexual Behaviour

Abstract. Pituitary and testicular function was studied in pubertal and adult rabbits with pseudohermaphroditism secondary to immunization of mothers against testosterone. Circulating testosterone, LH and FSH levels showed a developmental pattern during sexual maturation, similar to that observed in controls. Plasma FSH levels were elevated in male pseudohermaphrodites despite normal plasma testosterone concentrations. Fighting, male sexual behaviour and coitus occurred normally as in controls. The testicular response to endogenous elevated LH levels and the pituitary LH and FSH responses to LRH injection and to castration were similar in affected males and in controls. These observations suggest that inhibition of the central effects of androgens during the embryonic and perinatal period has little or no effect on the differentiation and maturation of the hypothalamo-pituitary-testicular axis in rabbit.

scholarly journals Male mating behaviour in relation to female sexual swellings, socio-sexual behaviour and hormonal changes in wild Barbary macaques

2013 ◽  
Vol 63 (1) ◽  
pp. 32-39 ◽  
Author(s):  
Christopher Young ◽  
Bonaventura Majolo ◽  
Michael Heistermann ◽  
Oliver Schülke ◽  
Julia Ostner
Keyword(s):  
Sexual Behaviour ◽  
Mating Behaviour ◽  
Male Mating ◽  
Hormonal Changes ◽  
Barbary Macaques ◽  
Sexual Swellings

TESTOSTERONE AND OESTRADIOL SUPPRESSION OF LH AND FSH IN ADULT MALE RATS: DURATION OF CASTRATION, DURATION OF TREATMENT AND COMBINED TREATMENT

1973 ◽  
Vol 73 (1) ◽  
pp. 11-21 ◽  
Author(s):  
R. S. Swerdloff ◽  
P. C. Walsh
Keyword(s):  
Adult Male ◽  
Testosterone Propionate ◽  
Combined Treatment ◽  
Male Rats ◽  
Low Doses ◽  
Duration Of Treatment ◽  
Serum Lh ◽  
Oestradiol Benzoate ◽  
Hypothalamic Pituitary Axis ◽  
Androgen Effect

ABSTRACT The effects of androgens and oestrogens on serum LH and FSH in castrated rats were evaluated with regard to the modifying influences of duration of castration, duration of treatment and combined oestrogen-androgen effect. Serum LH was not greatly influenced by these variables. In contrast, serum FSH was shown to be more resistant to suppression by both steroids after at least five days of castration, requiring a longer duration of treatment to be suppressed to intact levels. Combined treatment of submaximally suppressive doses of testosterone propionate and oestradiol benzoate resulted in no additive effect on lowering serum FSH. Low doses of both androgens and oestrogens resulted in elevated levels of serum LH and FSH, suggesting that the adult male hypothalamic-pituitary axis may be responsive to positive feedback. In all studies, testosterone preferentially suppressed serum LH as compared to serum FSH. In contrast, oestradiol administration produced parallel inhibition of both LH and FSH. It is emphasized that neither oestrogen nor androgen alone, nor in combination, resulted in preferential inhibition of serum FSH over LH.

Effects of progesterone and RU486 on the development and expression of adult male sexual behaviour and gene expression in the amygdala and preoptic area of the hypothalamus

2012 ◽  
Vol 24 (7) ◽  
pp. 916 ◽  
Author(s):  
A. B. Breton ◽  
K. J. Austin ◽  
M. G. Leedy ◽  
B. M. Alexander
Keyword(s):  
Gene Expression ◽  
Adult Male ◽  
Sexual Behaviour ◽  
Preoptic Area ◽  
Corn Oil ◽  
Sexual Interest ◽  
Neonatal Rat ◽  
Male Rats ◽  
Altered Expression ◽  
Male Sexual Behaviour

The number of progesterone receptors is greater in the male than female neonatal rat hypothalamus. The aims of the present study were to determine developmental effects of progesterone on the expression of adult male sexual behaviour and whether changes in behaviour were reflected by altered gene expression within the hypothalamic preoptic area (POA) or medial amygdala. Male rats were treated with progesterone (40 µg kg–1, i.p.), the progesterone receptor antagonist RU486 (40 µg kg–1, i.p.) or an equal volume of vehicle (10% ethanol, 90% corn oil) on postnatal Days 1–5. Treatment with either progesterone or RU486 inhibited (P ≤ 0.07) the initial expression of consummatory sexual behaviour at 10.5 weeks of age without influencing growth or serum concentrations of testosterone. Sexual interest, as measured by latency to exhibiting mounting behaviour or the number of mounts achieved, was not influenced by treatment with either progesterone or RU486. The effects of treatment with progesterone or RU486 on sexual behaviour were diminished by experience. Microarray analysis of the POA indicated 61 genes that were upregulated and 49 that were downregulated (P ≤ 0.01) following RU486 treatment of male rats. However, the altered expression of selected genes was not confirmed by real-time reverse transcription–polymerase chain reaction. The expression of targeted genes within the amygdala was not influenced by treatment with either progesterone or RU486. Neonatal treatment with RU486, but not progesterone, decreased testes weight (P = 0.02) without affecting testes morphology. The results indicate that altering the progesterone environment during a critical developmental period affects the expression of behaviour, but that changes in behaviour are not mirrored by the altered expression of selected genes.

INTERACTION OF GONADAL STEROIDS AND THEIR EFFECT ON SEXUAL BEHAVIOUR IN THE RABBIT

1969 ◽  
Vol 45 (3) ◽  
pp. 407-413 ◽  
Author(s):  
C. BEYER ◽  
N. VIDAL ◽  
P. G. McDONALD
Keyword(s):  
Sexual Behaviour ◽  
Mating Behaviour ◽  
Physiological Role ◽  
Significant Inhibition ◽  
Gonadal Steroids ◽  
Progesterone Treatment ◽  
Maximum Inhibition ◽  
Oestradiol Benzoate

SUMMARY The effect of progestins on mating and pseudomale behaviour was studied in ovariectomized rabbits receiving 0·5 μg. oestradiol benzoate twice daily. Single injections of 0·5, 1·0 and 2·0 mg. progesterone resulted in a 50, 75 and 100% inhibition of mating behaviour respectively. In all groups maximum inhibition occurred 24 hr. after progesterone treatment. Pseudomale behaviour was also inhibited by progesterone but the response was more variable. Single injections of 8 or 20 mg. 20α-hydroxypregn-4-en-3-one did not produce a significant inhibition of either mating or pseudomale behaviour. The physiological role of these hormones in regulating sexual behaviour is discussed.

FEMALE SEXUAL BEHAVIOUR IN MALE GOLDEN HAMSTERS

1971 ◽  
Vol 51 (4) ◽  
pp. 615-620 ◽  
Author(s):  
LEONORE TIEFER ◽  
W. A. JOHNSON
Keyword(s):  
Adult Male ◽  
Dose Response ◽  
Sexual Behaviour ◽  
Male Rats ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Oestradiol Benzoate ◽  
Male Golden Hamsters ◽  
Lordosis Behaviour

SUMMARY Four groups of adult male hamsters were castrated and injected with either 6 μg oestradiol benzoate (OB), 100 μg OB, 6 μg OB plus 0·5 mg progesterone or 100 μg OB plus 0·5 mg progesterone. In repeated tests with virile males, all the injected males showed lordosis behaviour similar, but quantitatively inferior, to that of female hamsters. Uninjected controls showed no lordosis. There was no dose—response relationship between the two doses of oestrogen. Progesterone significantly facilitated the quantity and quality of lordosis behaviour shown. This is in contrast with previous reports of the absence of facilitation by progesterone in male rats. After cessation of hormone injections the animals continued to display the lordosis response for several weeks.

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