The new endothelin receptor antagonist macitentan: Prospects for therapy of pulmonary arterial hypertension

Terapevticheskii arkhiv ◽

10.17116/terarkh201688789-97 ◽

2016 ◽

Vol 88 (7) ◽

pp. 89

Author(s):

S. N. Avdeev

Keyword(s):

Pulmonary Arterial Hypertension ◽

Arterial Hypertension ◽

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pulmonary Arterial

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Effects of the endothelin receptor antagonist bosentan on hemodynamics and exercise capacity in Japanese patients with mildly symptomatic pulmonary arterial hypertension

Heart and Vessels ◽

10.1007/s00380-014-0544-1 ◽

2014 ◽

Vol 30 (6) ◽

pp. 798-804 ◽

Author(s):

Masaru Hatano ◽

Hidehiro Yamada ◽

Keiichi Fukuda ◽

Koichiro Yoshioka ◽

Masanori Funauchi ◽

...

Keyword(s):

Pulmonary Arterial Hypertension ◽

Arterial Hypertension ◽

Receptor Antagonist ◽

Exercise Capacity ◽

Japanese Patients ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pulmonary Arterial

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SERAPHIN haemodynamic substudy: the effect of the dual endothelin receptor antagonist macitentan on haemodynamic parameters and NT-proBNP levels and their association with disease progression in patients with pulmonary arterial hypertension

European Heart Journal ◽

10.1093/eurheartj/ehx025 ◽

2017 ◽

Vol 38 (15) ◽

pp. 1147-1155 ◽

Author(s):

Nazzareno Galiè ◽

Pavel Jansa ◽

Tomás Pulido ◽

Richard N. Channick ◽

Marion Delcroix ◽

...

Keyword(s):

Pulmonary Arterial Hypertension ◽

Arterial Hypertension ◽

Receptor Antagonist ◽

Disease Progression ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Haemodynamic Parameters ◽

Pulmonary Arterial

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Pharmacokinetic and pharmacodynamic evaluation of macitentan, a novel endothelin receptor antagonist for the treatment of pulmonary arterial hypertension

Expert Opinion on Drug Metabolism & Toxicology ◽

10.1517/17425255.2015.1000859 ◽

2015 ◽

Vol 11 (3) ◽

pp. 437-449 ◽

Author(s):

Patricia N Sidharta ◽

Stephan Krähenbühl ◽

Jasper Dingemanse

Keyword(s):

Pulmonary Arterial Hypertension ◽

Arterial Hypertension ◽

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pulmonary Arterial

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Endothelin receptor antagonist and airway dysfunction in pulmonary arterial hypertension

Respiratory Research ◽

10.1186/1465-9921-10-129 ◽

2009 ◽

Vol 10 (1) ◽

Author(s):

Annette S Droste ◽

David Rohde ◽

Mirko Voelkers ◽

Arthur Filusch ◽

Thomas Bruckner ◽

...

Keyword(s):

Pulmonary Arterial Hypertension ◽

Arterial Hypertension ◽

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pulmonary Arterial

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Novel Dual Endothelin Receptor Antagonist Macitentan Reverses Severe Pulmonary Arterial Hypertension in Rats

Journal of Cardiovascular Pharmacology ◽

10.1097/fjc.0000000000000141 ◽

2014 ◽

Vol 64 (5) ◽

pp. 473-480 ◽

Author(s):

Mutsumi Kunita-Takanezawa ◽

Kohtaro Abe ◽

Yoshitaka Hirooka ◽

Yukimitsu Kuwabara ◽

Katsuya Hirano ◽

...

Keyword(s):

Pulmonary Arterial Hypertension ◽

Arterial Hypertension ◽

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pulmonary Arterial ◽

Severe Pulmonary Arterial Hypertension

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Corrigendum to ‘‘An overview of the preclinical toxicity and potential carcinogenicity of sitaxentan (Thelin®), a potent endothelin receptor antagonist developed for pulmonary arterial hypertension” [Regul. Toxicol. Pharmacol. 2012, 95–103]

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2012.07.012 ◽

2012 ◽

Vol 64 (3) ◽

pp. 490

Author(s):

Keith Owen ◽

David M. Cross ◽

Mazin Derzi ◽

Elizabeth Horsley ◽

Fiona L. Stavros

Keyword(s):

Pulmonary Arterial Hypertension ◽

Arterial Hypertension ◽

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pulmonary Arterial

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Oral Treprostinil for the Treatment of Pulmonary Arterial Hypertension in Patients on Background Endothelin Receptor Antagonist and/or Phosphodiesterase Type 5 Inhibitor Therapy (The FREEDOM-C Study)

CHEST Journal ◽

10.1378/chest.11-2212 ◽

2012 ◽

Vol 142 (6) ◽

pp. 1383-1390 ◽

Author(s):

Victor F. Tapson ◽

Fernando Torres ◽

Fiona Kermeen ◽

Anne M. Keogh ◽

Roblee P. Allen ◽

...

Keyword(s):

Pulmonary Arterial Hypertension ◽

Arterial Hypertension ◽

Receptor Antagonist ◽

Inhibitor Therapy ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Phosphodiesterase Type 5 Inhibitor ◽

Pulmonary Arterial ◽

Phosphodiesterase Type

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Device Closure of a Large Atrial Septal Defect in a Patient with Severe Pulmonary Arterial Hypertension after 1 Year Use of an Oral Endothelin Receptor Antagonist

Journal of Cardiovascular Ultrasound ◽

10.4250/jcu.2013.21.3.140 ◽

2013 ◽

Vol 21 (3) ◽

pp. 140 ◽

Author(s):

In Hyun Jung ◽

Sang Yun Lee ◽

Sook Jin Lee ◽

Joo Young Lee ◽

Nam Jin Park ◽

...

Keyword(s):

Pulmonary Arterial Hypertension ◽

Arterial Hypertension ◽

Atrial Septal Defect ◽

Receptor Antagonist ◽

Septal Defect ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Device Closure ◽

Pulmonary Arterial ◽

Severe Pulmonary Arterial Hypertension

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Oral Treprostinil for the Treatment of Pulmonary Arterial Hypertension in Patients Receiving Background Endothelin Receptor Antagonist and Phosphodiesterase Type 5 Inhibitor Therapy (The FREEDOM-C2 Study)

CHEST Journal ◽

10.1378/chest.12-2875 ◽

2013 ◽

Vol 144 (3) ◽

pp. 952-958 ◽

Author(s):

Victor F. Tapson ◽

Zhi-Cheng Jing ◽

Kai-Feng Xu ◽

Lei Pan ◽

Jeremy Feldman ◽

...

Keyword(s):

Pulmonary Arterial Hypertension ◽

Arterial Hypertension ◽

Receptor Antagonist ◽

Inhibitor Therapy ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Phosphodiesterase Type 5 Inhibitor ◽

Pulmonary Arterial ◽

Phosphodiesterase Type

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VIP and endothelin receptor antagonist: An effective combination against experimental pulmonary arterial hypertension

Respiratory Research ◽

10.1186/1465-9921-12-141 ◽

2011 ◽

Vol 12 (1) ◽

Author(s):

Sayyed A Hamidi ◽

Richard Z Lin ◽

Anthony M Szema ◽

Sergey Lyubsky ◽

Ya Ping Jiang ◽

...

Keyword(s):

Pulmonary Arterial Hypertension ◽

Arterial Hypertension ◽

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Effective Combination ◽

Pulmonary Arterial

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