scholarly journals The Effect of Anthocyanins on Microcirculation and Retrobulbar Blood Flow in Ocular Pathology

2019 ◽  
Vol 16 (3) ◽  
pp. 360-365
Author(s):  
T. N. Kiseleva ◽  
T. V. Sudovskaya ◽  
M. S. Zaitsev ◽  
K. V. Lugovkina
Keyword(s):  
Blood Flow ◽  
Metabolic Regulation ◽  
Vascular Reactivity ◽  
Open Angle Glaucoma ◽  
Visual Fields ◽  
Age Related Macular Degeneration ◽  
Positive Effects ◽  
Age Related ◽  
Retrobulbar Blood Flow ◽  
Functional Indices

The literature review presents information on positive effects of anthocyanins on functional indices of cardiovascular system, vascular reactivity of main arteries, microcirculation and retrobulbar blood flow. The positive effect of anthocyanins on the reactivity of main arteries was detected using non-invasive ultrasound method for assessment of flow-mediated dilation andendothelial function. Numerous randomised-controlled trials showed the effectiveness of the long-term supplementation with anthocyanins (during 6–24 months) in correction of microcirculation impairment and functional indices of visual system. The increase of plasma endothelin-1 (ET-1) level and the pathological vascular reactivity have been noted in ocular ischemic diseases such as diabetic retinopathy, occlusion of retinal veins and arteries. We registered the normalization of the plasma ET-1 level, significant improvement of blood flow in neuroretinal rim area and peripapillary area of retina without changes in mean indices of intraocular pressure and ocular perfusion pressure in patients with open-angle glaucoma after anthocyanins administration. There was no progression of visual fields defects. The resulting effect of anthocyanins supplementation consists of metabolic regulation of blood flow and flow-dependent vasodilatation due to the influence on vascular endothelium.Anthocyanins also increase the expression of endothelial nitric oxide (NO) synthase, an enzyme that generates powerful endogenous vasodilator NO. Anthocyanins regulate a number of complex immune and inflammatory signaling pathways involved in maintaining vascular functional activity. Positive dynamic of blood flow velocities and normalization of resistance indices in ocular vessels were detected in patients with dry age-related macular degeneration after 2 months anthocyanins supplementation. That indicates the improvement of ocular blood flow circulation and favorable prognosis for retinal dystrophies. The instrumental examination of blood flow in different vascular systems including microcirculation and main arteries are very useful for assessment of the effectiveness of anthocyanin supplementation.

EFFECT OF INTRAVITREAL BEVACIZUMAB ON RETROBULBAR BLOOD FLOW IN INJECTED AND UNINJECTED FELLOW EYES OF PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION

Retina ◽  
2012 ◽  
Vol 32 (5) ◽  
pp. 967-971 ◽  
Author(s):  
Hamid Hosseini ◽  
Mehrzad Lotfi ◽  
Mina Heidari Esfahani ◽  
Nariman Nassiri ◽  
Mohammad Reza Khalili ◽  
...  
Keyword(s):  
Blood Flow ◽  
Macular Degeneration ◽  
Intravitreal Bevacizumab ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Retrobulbar Blood Flow ◽  
Fellow Eyes

Does Ranibizumab (Lucentis®) Change Retrobulbar Blood Flow in Patients with Neovascular Age-Related Macular Degeneration

2012 ◽  
Vol 47 (3) ◽  
pp. 141-145 ◽  
Author(s):  
Ahmet Mete ◽  
Oguzhan Saygili ◽  
Alper Mete ◽  
Kivanc Gungor ◽  
Metin Bayram ◽  
...  
Keyword(s):  
Blood Flow ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Retrobulbar Blood Flow

Effects of Betaxolol and Latanoprost on Ocular Blood flow and Visual Fields in Patients with Primary Open-Angle Glaucoma

2004 ◽  
Vol 14 (3) ◽  
pp. 211-219 ◽  
Author(s):  
E.F. Erkin ◽  
S. Tarhan ◽  
Ö.R. Kayikçioğlu ◽  
H. Devecı ◽  
C. Güler ◽  
...  
Keyword(s):  
Blood Flow ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Visual Fields ◽  
Ocular Blood Flow ◽  
Open Angle

scholarly journals The microbiome and ophthalmic disease

2018 ◽  
Vol 244 (6) ◽  
pp. 419-429 ◽  
Author(s):  
Adam D Baim ◽  
Asadolah Movahedan ◽  
Asim V Farooq ◽  
Dimitra Skondra
Keyword(s):  
Ocular Surface ◽  
Open Angle Glaucoma ◽  
Age Related Macular Degeneration ◽  
Therapeutic Interventions ◽  
Gastrointestinal Microbiota ◽  
Treatment And Prevention ◽  
Age Related ◽  
Microbiome Research ◽  
Ophthalmic Diseases ◽  
Ophthalmic Disease

Progress in microbiome research has accelerated in recent years. Through the use of 16S rRNA assays and other genomic sequencing techniques, researchers have provided new insights about the communities of microorganisms that inhabit human and animal hosts. There is mounting evidence about the importance of these ‘microbiotas’ in a wide variety of disease states, suggesting potential targets for preventative and therapeutic interventions. Until recently, however, the microbiome received relatively little attention in ophthalmology. This review explores emerging research on the roles that ocular and extraocular microbiotas may play in the pathogenesis and treatment of ophthalmic diseases. These include diseases of the ocular surface as well as autoimmune uveitis, age-related macular degeneration, and primary open angle glaucoma. Many questions remain about the potential impacts of microbiome research on the diagnosis, treatment, and prevention of ophthalmic disease. In light of current findings, we suggest directions for future study as this exciting area of research continues to expand. Impact statement This review describes a growing body of research on relationships between the microbiome and eye disease. Several groups have investigated the microbiota of the ocular surface; dysregulation of this delicate ecosystem has been associated with a variety of pro-inflammatory states. Other research has explored the effects of the gastrointestinal microbiota on ophthalmic diseases. Characterizing the ways these microbiotas influence ophthalmic homeostasis and pathogenesis may lead to research on new techniques for managing ophthalmic disease.

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