scholarly journals A study of prevalence of abnormal EEG and its association between various clinical presentations of atypical febrile seizures

2020 ◽  
Vol 8 (1) ◽  
pp. 120
Author(s):  
Bruntha Priyavathani J. ◽  
Sriram Pothapregada ◽  
Anuradha Varadhan ◽  
Suresh C. Thirunavukarasu
Keyword(s):  
Clinical Features ◽  
Febrile Seizure ◽  
Age At Onset ◽  
Predictive Marker ◽  
Febrile Seizures ◽  
Quantitative Eeg ◽  
Clinical Presentations ◽  
Long Term Follow Up ◽  
Eeg Recordings

Background: Quantitative EEG is a rapidly emerging tool in the diagnosis and follow up of various neurological disorders and can act as predictive marker for subsequent epilepsy in children with complex febrile seizure. The present study aimed to estimate the prevalence of abnormal electroencephalogram (EEG) and to find the association between Quantitative EEG (qEEG) and various clinical features of atypical febrile seizures(AFS).Methods: EEG was recorded along with clinical features including the age at onset, duration of episode, number of episodes in a day, type of seizure and the recurrences from the children aged between 6-60 months with atypical febrile seizures. EEG recordings were classified into Normal and abnormal EEG with epileptiform changes by the expert interpretation and the distribution of above said clinical features in the both groups were analyzed. It is also attempted to find the association between qEEG and few of the clinical features.Results: Prevalence of abnormal EEG in atypical febrile seizures was 33.9%. There were no significant differences in the distribution of abnormal EEG and their association with various clinical features of AFS. Significantly increased absolute power of θ and α waves were recorded from the frontal montages in the children with epileptiform changes in the EEG.Conclusions: qEEG changes can be also considered as marker of severity of febrile seizure episodes. Many prospective studies with long-term follow up are required to establish the predictability of future epilepsy by qEEG.

scholarly journals Angelman Syndrome: Need for Further Illumination in the Theater of the Happy Puppet

2005 ◽  
Vol 5 (6) ◽  
pp. 220-222 ◽  
Author(s):  
Raman Sankar
Keyword(s):  
Molecular Diagnosis ◽  
Angelman Syndrome ◽  
De Novo ◽  
Genetic Disorder ◽  
Age At Onset ◽  
Epileptic Seizures ◽  
Febrile Seizures ◽  
Eeg Recordings ◽  
Medical Histories

Analysis of the Characteristics of Epilepsy in 37 Patients with the Molecular Diagnosis of Angelman Syndrome Galvan-Manso M, Campistol J, Conill J, Sanmarti FX Epileptic Disord 2005;7:19–25 Angelman syndrome is a genetic disorder caused by defects in the maternally inherited imprinted domain located on chromosome 15q11-q13. Most patients with Angelman syndrome have severe mental retardation, characteristic physical appearance, behavioral traits, and severe, early-onset epilepsy. We retrospectively reviewed the medical histories of 37 patients, all with the molecular diagnosis of Angelman syndrome and at least 3 years of follow-up in our neurology department, for further information about their epilepsy: age at onset, type of seizures initially and during follow-up, EEG recordings, treatments, and response. The molecular studies showed 87% deletions de novo; 8% uniparental, paternal disomy; and 5% imprinting defects. The median age at diagnosis was 6.5 years, with 20% having begun to manifest febrile seizures at an average age of 1.9 years. Nearly all (95%) had epilepsy, the majority younger than 3 years (76%). The most frequent seizure types were myoclonic, atonic, generalized tonic–clonic, and atypical absences. At onset, two patients exhibited West syndrome. EEG recordings typical of Angelman syndrome were found in 68%. Normalization of EEG appeared in 12 patients after 9 years. Control of epileptic seizures improved after the age of 8.5 years. The most effective treatments were valproic acid and clonazepam. We conclude that epilepsy was present in nearly all of our cases with Angelman syndrome and that the EEG can be a useful diagnostic tool. On comparing the severity of epilepsy with the type of genetic alteration, we did not find any statistically significant correlations.

Clinical Predictive Factors of Pathological EEG in Children with Febrile Seizures and Their Association with Subsequent Epileptic Seizures

2021 ◽  
Author(s):  
Khouloud Kchaou ◽  
Ines Kammoun ◽  
Sahar Chakroun ◽  
Asma Haddar ◽  
Kaouthar Masmoudi
Keyword(s):  
Febrile Seizure ◽  
Epileptic Seizures ◽  
Febrile Seizures ◽  
Psychomotor Retardation ◽  
Only Children ◽  
Psychomotor Delay ◽  
Eeg Abnormalities ◽  
Eeg Data ◽  
Eeg Recordings

AbstractThe objective of this study was to identify clinical parameters predicting either a pathological EEG or a subsequent epileptic seizure (SES), based on the relation between paroxysmal EEG abnormalities and clinical features in children who presented at least one febrile seizure (FS). We collected data of children who presented to our department during the period 2013 to 2018 for EEG recording as part of their febrile seizure assessment. Only children aged between 1 month to 5 years were included. Both the clinical and EEG data were retrospectively collected and statistically studied. We performed a detailed analysis of the EEG recordings. SES was identified for patients with sufficient follow-up. A total of 120 children were included in the study, of whom 48% had EEG abnormalities. Psychomotor retardation (p = 0.002), completion of an EEG within 7 days of the last FS (p = 0.046), and late age (> 3 years) of the first FS onset (p = 0.021) were significantly associated with a pathological EEG. In multivariate analysis, performing early EEG (< 7 days from the last FS) (odds ratio [OR]: 2.35; p = 0.043; confidence interval [CI]: 1.028–5.375) and psychomotor retardation (OR: 4.19; p = 0.008; CI: 1.46–12) were independent predictors of a pathological EEG. Of 120 patients, 45 had a follow-up. However, only 10 (22.22%) had SES. Children with SES tended more to have a psychomotor delay, compared with children without SES (50% vs. 14.28%, p = 0.029). Moreover, the percentage of initial abnormal EEG in patients with SES was significantly higher than those without SES (70% vs. 34.28%, p = 0.05). Even though some FS characteristics predict EEG abnormalities, they are not always associated with SES. We highlight the importance of performing an EEG in the group of children who had both FS and psychomotor retardation. This is most likely the group at the highest risk of developing epilepsy.

A five year follow-up study of dementia in persons with Down's syndrome: early symptoms and patterns of deterioration

2000 ◽  
Vol 17 (1) ◽  
pp. 5-11 ◽  
Author(s):  
Mary P Cosgrave ◽  
Janette Tyrrell ◽  
Mary McCarron ◽  
Michael Gill ◽  
Brian A Lawlor
Keyword(s):  
Clinical Features ◽  
Rating Scales ◽  
Age At Onset ◽  
Down's Syndrome ◽  
Memory Loss ◽  
Down’S Syndrome ◽  
Personal Hygiene ◽  
Follow Up Study ◽  
Diagnosis Of Dementia

AbstractObjectives: To investigate the development of dementia over a five year follow up period in a population of females with Down's syndrome; to examine age at onset and duration of dementia in the population; to document the clinical features of dementia and to highlight scores on functional and cognitive rating scales at diagnosis of dementia and at the onset of complete dependency.Method: A five year follow-up study of 80 female subjects on prevalence of dementia, early clinical features of dementia and patterns of scoring on rating scales at diagnosis and end-stage dementia was completed. Results: Over the five year study period the number of subjects diagnosed with dementia rose from seven (8.75%) to 35 (43.75%). Age related prevalence figures showed that dementia was more common with increasing age. The earliest recognisable symptoms of dementia were memory loss, spatial disorientation and loss of independence especially in the area of personal hygiene. These findings were confirmed by the rating scales used in the study.Conclusions: The earliest recognisable clinical features of dementia include memory loss and increased dependency. The results of this study should facilitate earlier diagnosis of dementia in DS.

Clinical Features and Long-Term Follow-Up of 20 Cases of Parakeratosis Pustulosa

2009 ◽  
Vol 15 (4) ◽  
pp. 259-263 ◽  
Author(s):  
Antonella Tosti ◽  
Anna Maria Peluso ◽  
Valeria Zucchelli
Keyword(s):  
Clinical Features ◽  
Long Term Follow Up

Medullary Thyroid Carcinoma: Clinical Features and Long-Term Follow-up of Seventy-Eight Patients Treated Between 1969 and 1986

Thyroid ◽  
1998 ◽  
Vol 8 (6) ◽  
pp. 517-523 ◽  
Author(s):  
M.E. GIRELLI ◽  
D. NACAMULLI ◽  
M.R. PELIZZO ◽  
D. DE VIDO ◽  
C. MIAN ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Clinical Features ◽  
Medullary Thyroid ◽  
Long Term Follow Up

Clinical features, long-term follow-up and outcome of a large cohort of patients with Chronic Granulomatous Disease: An Italian multicenter study

2008 ◽  
Vol 126 (2) ◽  
pp. 155-164 ◽  
Author(s):  
Baldassarre Martire ◽  
Roberto Rondelli ◽  
Annarosa Soresina ◽  
Claudio Pignata ◽  
Teresa Broccoletti ◽  
...  
Keyword(s):  
Chronic Granulomatous Disease ◽  
Clinical Features ◽  
Multicenter Study ◽  
Large Cohort ◽  
Granulomatous Disease ◽  
Long Term Follow Up

scholarly journals Long-Term Follow-Up, Clinical Features, and Quality of Life in a Series of 103 Patients With Hyperimmunoglobulinemia D Syndrome

Medicine ◽  
2008 ◽  
Vol 87 (6) ◽  
pp. 301-310 ◽  
Author(s):  
Jeroen C. H. van der Hilst ◽  
Evelien J. Bodar ◽  
Karyl S. Barron ◽  
Joost Frenkel ◽  
Joost P. H. Drenth ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Features ◽  
Long Term Follow Up

Clinical Evaluation and Long-Term Follow-Up of Dogs Having Coronoidectomy for Elbow Incongruity

2003 ◽  
Vol 39 (5) ◽  
pp. 473-478 ◽  
Author(s):  
Margaret Puccio ◽  
Dominic J. Marino ◽  
Joseph D. Stefanacci ◽  
Brian McKenna
Keyword(s):  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Disease Entity ◽  
Radiographic Findings ◽  
Clinical Presentations ◽  
Long Term Follow Up ◽  
The Mean ◽  
Joint Incongruity

A retrospective study was performed describing the clinical presentations, radiographic findings, and surgical outcomes of 17 dogs (18 elbows) following medial coronoidectomy for the treatment of elbow joint incongruity as a sole disease entity. Complete resolution of lameness was achieved in 100% of the cases. The mean radiographic arthrosis grade progressed in 70% of the cases. Results of this study indicate that resolution of clinical lameness may be achieved with medial coronoidectomy in dogs with elbow incongruity; however, progression of degenerative joint disease with unknown, long-term clinical significance can be expected after surgery.

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