Fibrocartilagenous dysplasia in distal femur: A rare histopathological finding

Fibrocartilaginous dysplasia (FCD) or massive cartilaginous differentiation in fibrous dysplasia are interchangeably used terms. It is a rare variant of fibrous dysplasia (FD) which is benign, lytic, and expansile bone lesion and causes progressive deformity in the bones and may lead to pathological fracture. Radiologically, FCD may confused with cartilaginous benign and malignant bone tumours. FCD usually shows calcification in imaging. Surgical curettage or corrective osteotomy and histopathological examination of these lesions is necessary to differentiate it from other cartilaginous tumours. Here we report case of fibrocartilaginous dysplasia of distal femur in a 4-year-old male child.

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Fibrous Dysplasia with Massive Cartilaginous Differentiation (Fibrocartilaginous Dysplasia) in the Proximal Femur: A Case Report and Review of the Literature

Case Reports in Oncology ◽

10.1159/000443476 ◽

2016 ◽

Vol 9 (1) ◽

pp. 126-133 ◽

Cited By ~ 3

Author(s):

Hideo Morioka ◽

Yasuhiro Kamata ◽

Kazumasa Nishimoto ◽

Michiro Susa ◽

Kazutaka Kikuta ◽

...

Keyword(s):

Fibrous Dysplasia ◽

Proximal Femur ◽

Fibrous Tissue ◽

Bone Lesion ◽

Pathological Findings ◽

Review Of The Literature ◽

Radiographic Findings ◽

Fibrocartilaginous Dysplasia ◽

Multiple Enchondromatosis ◽

Spindle Cell Proliferation

Fibrous dysplasia (FD) is a monostotic or polyostotic benign bone lesion with spindle-cell proliferation in woven bone and stroma. Rarely, cartilaginous differentiation can be seen in the lesions of FD. FD with massive cartilaginous differentiation is called fibrocartilaginous dysplasia (FCD) and is considered a rare variant of FD. Although pathological findings of FD show irregular immature bone formation without osteoblastic rimming in fibrous tissue, and rarely show very small amounts of cartilage, histological images of FCD are said to show that cartilage with a relatively high cell density is present in the majority and that FD-like findings are seen in parts of it. The most characteristic feature of FCD on images is calcification in the lesions reflecting cartilaginous tissue. On the other hand, typical radiographic findings of FD include shadows with a ground-glass appearance and thinning and bulging of the cortical bone, the observation if calcification is not usual. Therefore, in the diagnosis of FCD, differentiation from multiple enchondromatosis, Ollier disease, chondrosarcoma, and chondrosarcoma secondary to FD is necessary, and it seems important to make a careful diagnosis based not only on the pathological findings but also on imaging and clinical findings. Herein, we report on a case of FD of the proximal femur associated with intralesional extensive cartilaginous differentiation in which a pathological fracture occurred during follow-up, with a review of the literature.

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Tumour Endoprosthetic Reconstruction for Primary Aggressive and Malignant Bone Tumours of the Distal Femur

Malaysian Orthopaedic Journal ◽

10.5704/moj.1311.007 ◽

2013 ◽

Vol 7 (3) ◽

pp. 1-5 ◽

Cited By ~ 4

Author(s):

DA Rubio ◽

MVT Serrano ◽

EHM Wang

Keyword(s):

Distal Femur ◽

Bone Tumours ◽

Endoprosthetic Reconstruction ◽

Malignant Bone Tumours

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Fibrocartilaginous Dysplasia of the Bone: A Rare Variant of Fibrous Dysplasia

Cureus ◽

10.7759/cureus.448 ◽

2016 ◽

Author(s):

Raju Vaishya ◽

Amit Kumar Agarwal ◽

Nishint Gupta ◽

Vipul Vijay

Keyword(s):

Fibrous Dysplasia ◽

Rare Variant ◽

Fibrocartilaginous Dysplasia

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Lesion with blue bone-a case report

Journal of Pathology of Nepal ◽

10.3126/jpn.v8i1.19464 ◽

2018 ◽

Vol 8 (1) ◽

pp. 1323-1325

Author(s):

Laila Mohamed Ilias ◽

Babitha Alingal Mohammed ◽

Roshini PS ◽

Anupama Ponniah ◽

Poornima Vijayan

Keyword(s):

Histopathological Examination ◽

Fibrous Tissue ◽

Bone Lesion ◽

Metacarpal Bone ◽

Cortical Surface ◽

Bizarre Parosteal Osteochondromatous Proliferation ◽

X Ray ◽

Spindle Cells ◽

Small Bones ◽

Hands And Feet

Bizzare parosteal osteochondromatous proliferation, or Nora‘s lesion is a unique bone lesion that most often arises in the small bones of hands and feet. It is characterised by proliferation of chondroid, bony and fibrous tissue, and is occasionally misdiagnosed as a malignant process. Our case was a 31 yr old lady, who presented with a painless swelling near the 5th metacarpal bone of right hand. X-ray showed well marginated mineralised mass arising from the cortical surface of the metacarpal bone. Histopathological examination revealed bizarre parosteal osteochondromatous proliferation composed of varying amounts of cartilage, bone and spindle cells. Cartilage was hypercellular and chondrocytes were enlarged. Ossification was irregular and had a peculiar blue tinctorial quality.

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Monostotic fibrous dysplasia of the thoracic spine: clinopathological description and follow up

Journal of Neurosurgery Spine ◽

10.3171/spi.2004.100.4.0378 ◽

2004 ◽

Vol 100 (4) ◽

pp. 378-381 ◽

Cited By ~ 3

Author(s):

Mehmet Arazi ◽

Onder Guney ◽

Mustafa Ozdemir ◽

Omer Uluoglu ◽

Nuket Uzum

Keyword(s):

Fibrous Dysplasia ◽

Thoracic Spine ◽

Histopathological Examination ◽

En Bloc Resection ◽

Spinal Tumors ◽

En Bloc ◽

Content Type ◽

Thoracic Spinal ◽

Fine Print

✓ The authors report the case of a 53-year-old woman with monostotic fibrous dysplasia of the thoracic spine. The patient presented with a 1-month history of pain in the thoracic spinal region. En bloc resection of the lesion was successfully performed via a transthoracic approach, and a histopathological examination confirmed the diagnosis of fibrous dysplasia. At 24-month follow-up examination, pain and vertebral instability were absent. The findings in this case illustrate that, although very rare, monostotic fibrous dysplasia of the thoracic spine should be considered in the differential diagnosis of spinal tumors. Although a consensus for management of this disease has not been achieved, the authors recommend radical removal of all involved bone as well as internal fixation or bone graft—assisted fusion to achieve long-term stabilization.

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