Efficacy of OK-432 Therapy for the Incisionless Treatment of Head and Neck Cystic Masses: Case series

Head and neck masses can present in different pathologies that usually vary according to the age of the patient. We report five cases of benign head or neck masses occurring among patients of different ages who were managed at the Bahrain Defence Force Royal Medical Services Hospital, Ar-Rifaa, Bahrain, between 2005–2014. All of the patients were treated using the sclerotherapeutic agent OK-432. Although surgical removal is usually considered optimal treatment in the management of such cases, OK-432 appears to be a promising alternative.

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Oncosuppressor-Mutated Cell-Based Diagnostic Platform for Liquid Biopsy Diagnoses Benign Head and Neck Masses and Predicts Malignancy in Thyroid Nodules: Results from a Consecutive Cohort of Patients

European Thyroid Journal ◽

10.1159/000516421 ◽

2021 ◽

pp. 1-10

Author(s):

Mohamed Abdouh ◽

Roger Tabah ◽

Vincenzo Arena ◽

Manuel Arena ◽

Zu-hua Gao ◽

...

Keyword(s):

Head And Neck ◽

Cancer Patients ◽

Liquid Biopsy ◽

False Negative ◽

Surgical Removal ◽

Neck Masses ◽

Thyroid Neoplasia ◽

Patients At Risk ◽

Head And Neck Masses

Background: We reported that a novel oncosuppressor-mutated cell (OMC)-based platform has the potential for early cancer detection in healthy individuals and for identification of cancer patients at risk of developing metachronous metastases. Objective: Herein, we sought to determine the diagnostic accuracy of this novel OMC-based platform in a consecutive cohort of patients operated for suspicious head and neck masses. Methods: OMCs (BRCA1-deficient fibroblasts) were exposed to blood serum from patients with head and neck nodules before surgical removal. These cells were analyzed for their proliferation and survival. Treated OMCs were inoculated subcutaneously in NOD/SCID mice, and tumor growth was monitored over time. Results: OMCs exposed to serum from patients with malignant lesions displayed increased proliferation compared to those exposed to serum from patients with benign lesions. Only OMCs exposed to serum from patients diagnosed with malignant thyroid neoplasia generated a cancerous mass. The sensitivity of the test was 92%, with only 1 false negative out of 34 patients. Immunohistochemical staining showed that the cancerous masses were poorly differentiated adenocarcinomas with high proliferative index. Conclusions: These data show that liquid biopsy combined with an OMC-based in vivo platform has the potential to diagnose benign head and neck masses and predict whether a thyroid nodule is malignant. These results strengthen the concept that OMCs can be used to detect circulating malignant factors in cancer patients.

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Feasibility of Quantitative Diffusion Weighted MR Imaging with Calculated Apparent Diffusion Coefficients in Characterization of Pediatric Head and Neck Masses

Indian Journal of Public Health Research & Development ◽

10.37506/v10/i12/2019/ijphrd/192433 ◽

2019 ◽

Vol 10 (12) ◽

pp. 1577

Author(s):

Ahmed Gabr ◽

Ayman M. Nada ◽

Mohammed Gomaa ◽

Rania Hashem ◽

Ahmed Shokry ◽

...

Keyword(s):

Mr Imaging ◽

Head And Neck ◽

Diffusion Coefficients ◽

Apparent Diffusion Coefficients ◽

Neck Masses ◽

Diffusion Weighted ◽

Apparent Diffusion ◽

Head And Neck Masses

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Multiple b values of diffusion-weighted magnetic resonance imaging in evaluation of solid head and neck masses

Egyptian Journal of Radiology and Nuclear Medicine ◽

10.1186/s43055-019-0054-3 ◽

2019 ◽

Vol 50 (1) ◽

Cited By ~ 1

Author(s):

Rania Sobhy Abou khadrah ◽

Haytham Haroon Imam

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Head And Neck ◽

Resonance Imaging ◽

Adc Value ◽

Neck Masses ◽

Adc Values ◽

Weighted Magnetic Resonance Imaging ◽

The Mean ◽

Head And Neck Masses

Abstract Background Differentiation between malignant and benign masses is essential for treatment planning and helps in improving the prognosis of malignant tumors; the aim of this work is to determine the role of diffusion-weighted magnetic resonance imaging (DW-MRI) and the apparent diffusion coefficient (ADC) in the differentiation between benign and malignant solid head and neck masses by comparing diagnostic performance of low b values (0.50 and 400 s/mm2) versus high b values (800 and 1000 s/mm2) and comparing the result with histopathological finding. Results The study included 60 patients (34 male and 26 female) with solid head and neck masses > 1 cm who referred to radiodiagnosis department for MRI evaluation. Multiple b values were used 50, 400, 800, and 1000 s/mm2 (at least 2 b values). DWI and ADC value of all 60 patients were acquired. Mean ADC values of both malignant and benign masses were statistically measured and compared, and cut off value was determined. Solid head and neck masses in our study DWI with the use of high b value 800 and 1000 s/mm2 were of higher significance (P value 0.001*). There was a significant difference in the mean ADC value between benign and malignant masses (P < 0.01); solid masses were divided into 2 categories: (a) malignant lesions 46.7% (n = 28) with mean ADC value (0.82 ± 0.19) × 10−3 s/mm2 and (b) benign lesions 53.3% (n = 32) with mean ADC value (2.05 ± 0.46) × 10−3 s/mm2) with ADC cutoff value of 1.0 × 10−3 s/mm2 and 94% sensitivity, 93% specificity, negative predictive value (NPV) = 94%, positive predictive value (PPV) 93%, and an accuracy of 93.5%. Conclusion The DWI with ADC mapping were valuable as non-invasive tools in differentiating between benign and malignant solid head and neck masses. The use of high b value 800 and 1000 s/mm2 was of higher significance (P value 0.001*) in differentiation between benign and malignant lesion than that with low b values 0, 50, and 400 s/mm2 (0.01). The mean ADC values were significantly lower in malignant solid masses. Attention had to be paid to the choice of b values in MRI-DWI in the head and neck region.

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