Particle Image Velocimetry Measurements of a Dry Powder Inhaler Flow

Inhalation therapy for respiratory disorders is being increasingly delivered via dry powder inhalers (DPIs), which are breath-actuated devices that deliver pharmaceutical drug particles to the lungs. The motion of inhalation air, produced when a patient inhales through this device, supplies all energy for the entrainment, de-agglomeration, and dispersion of powder drug agglomerates into a fine drug particle aerosol. The aerosol performance is directly related to the fluid-mechanics of a given DPI device. These flow mechanisms are complex as they depend on the device design, inhalation flow rate, and the properties of the dry powder formulation used. Among these, the role of device design is crucial as it significantly affects not only the generation and properties of delivered aerosol, but also the capability of targeted regional drug deposition.