Polymer coating of carrier excipients modify aerosol performance of adhered drugs used in dry powder inhalation therapy

2012 ◽  
Vol 438 (1-2) ◽  
pp. 150-159 ◽  
Author(s):  
Daniela Traini ◽  
Santo Scalia ◽  
Handoko Adi ◽  
Elisabetta Marangoni ◽  
Paul M. Young
Keyword(s):  
Polymer Coating ◽  
Inhalation Therapy ◽  
Dry Powder Inhalation ◽  
Dry Powder ◽  
Aerosol Performance

scholarly journals Particle Image Velocimetry Measurements of a Dry Powder Inhaler Flow

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Vishal Chaugule ◽  
Larissa Gomes Dos Reis ◽  
David F. Fletcher ◽  
Paul M. Young ◽  
Daniela Traini ◽  
...  
Keyword(s):  
Particle Image ◽  
Dry Powder Inhaler ◽  
Inhalation Therapy ◽  
Device Design ◽  
Dry Powder ◽  
Drug Deposition ◽  
Aerosol Performance ◽  
Image Velocimetry ◽  
Flow Mechanisms

Inhalation therapy for respiratory disorders is being increasingly delivered via dry powder inhalers (DPIs), which are breath-actuated devices that deliver pharmaceutical drug particles to the lungs. The motion of inhalation air, produced when a patient inhales through this device, supplies all energy for the entrainment, de-agglomeration, and dispersion of powder drug agglomerates into a fine drug particle aerosol. The aerosol performance is directly related to the fluid-mechanics of a given DPI device. These flow mechanisms are complex as they depend on the device design, inhalation flow rate, and the properties of the dry powder formulation used. Among these, the role of device design is crucial as it significantly affects not only the generation and properties of delivered aerosol, but also the capability of targeted regional drug deposition.

scholarly journals Dose administration maneuvers and patient care in tobramycin dry powder inhalation therapy

2018 ◽  
Vol 548 (1) ◽  
pp. 182-191 ◽  
Author(s):  
Francesca Buttini ◽  
Anna Giulia Balducci ◽  
Gaia Colombo ◽  
Fabio Sonvico ◽  
Serena Montanari ◽  
...  
Keyword(s):  
Patient Care ◽  
Inhalation Therapy ◽  
Dry Powder Inhalation ◽  
Dry Powder ◽  
Dose Administration
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